Impact of neutrophil–lymphocyte ratio on long-term outcome in patients with craniopharyngioma

Zhang, Jing; He, Min; Li, Yong; Song, Yanlin; Wang, Yuelong; Liang, Ruichao; Chen, Hongxu; Xu, Jianguo

doi:10.1097/md.0000000000012375

Cited by 13 publications

(12 citation statements)

References 65 publications

(55 reference statements)

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“…NLR has been reported to be a useful prognostic factor for brain tumors, such as gliomas and brain metastases ( Supplementary Table 3) (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40). However, analyses of the prognostic significance of NLR in benign brain tumors have been limited (41)(42)(43). For meningiomas, Liang et al demonstrated that high leukocyte count and low LMR were independent predictive factors of high-grade meningiomas (13).…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Patients With Meningiomas

et al. 2020

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BackgroundMeningiomas are the most common benign intracranial tumors. However, even WHO grade I meningiomas occasionally show local tumor recurrence. Prognostic factors for meningiomas have not been fully established. Neutrophil-to-lymphocyte ratio (NLR) has been reported as a prognostic factor for several solid tumors. The prognostic value of NLR in meningiomas has been analyzed in few studies.Materials and MethodsThis retrospective study included 160 patients who underwent surgery for meningiomas between October 2010 and September 2017. We analyzed the associations between patients’ clinical data (sex, age, primary/recurrent, WHO grade, extent of removal, tumor location, peritumoral brain edema, and preoperative laboratory data) and clinical outcomes, including recurrence and progression-free survival (PFS).ResultsForty-four meningiomas recurred within the follow-up period of 3.8 years. WHO grade II, III, subtotal removal, history of recurrence, Ki-67 labeling index ≥3.0, and preoperative NLR value ≥2.6 were significantly associated with shorter PFS (P < 0.001, < 0.001, 0.002, < 0.001, and 0.015, respectively). Furthermore, NLR ≥ 2.6 was also significantly associated with shorter PFS in a subgroup analysis of WHO grade I meningiomas (P = 0.003). In univariate and multivariate analyses, NLR ≥2.6 remained as a significant predictive factor for shorter PFS in patients with meningioma (P = 0.014).ConclusionsNLR may be a cost-effective and novel preoperatively usable biomarker in patients with meningiomas.

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Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Patients With Meningiomas

et al. 2020

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“…Only 1 study characterized the preoperative inflammation-based scores in patients with pituitary tumors and investigated their usefulness in predicting clinically challenging or refractory disease ( 91 ). Unsurprisingly, rather unimpressive mean values of serum inflammation-based scores were seen ( 91 ), with NLR and PLR relatively low ( 3 , 18 , 21 , 36 ) and LMR relatively high ( 17 , 21 ) compared to malignant neoplasms, considering that pituitary tumors are benign and lack metastatic properties. Pituitary tumor cells secrete pro-inflammatory cytokines and growth factors ( 1 , 129 ), but their release into circulation and/or systemic repercussions may be less prominent than in other malignancies ( 91 ).…”

Section: Pituitary Tumorsmentioning

confidence: 99%

“…Two studies investigated the role of preoperative inflammation-based scores in patients with craniopharyngiomas ( Table 3 ) ( 6 , 36 ). Zhang et al observed a negative correlation between preoperative NLR and overall and progression-free survival.…”

Section: Craniopharyngiomasmentioning

confidence: 99%

“…Zhang et al observed a negative correlation between preoperative NLR and overall and progression-free survival. Patients with NLR ≥ 4 had larger tumors, lower rates of gross total resection, and worse quality of life, as well as lower overall and progression-free survival rates, suggesting preoperative NLR may be a predictor of long-term outcome in craniopharyngioma ( 36 ). Later, Chen et al observed higher preoperative NLR and lower PNI in papillary compared to patients with adamantinomatous craniopharyngioma, but no differences between primary or recurrent craniopharyngiomas regarding NLR, dNLR, PLR, LMR, and PNI.…”

Section: Craniopharyngiomasmentioning

confidence: 99%

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Serum Inflammation-based Scores in Endocrine Tumors

Marques

Vries

Dekkers

et al. 2021

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context Serum inflammation-based scores reflect systemic inflammatory response and/or patients’ nutritional status, and may predict clinical outcomes in cancer. While these are well-described and increasingly used in different cancers, their clinical usefulness in the management of patients with endocrine tumors is less known. Evidence acquisition A comprehensive PubMed search was performed using the terms “endocrine tumor”, “inflammation”, “serum inflammation-based score”, “inflammatory-based score”, “inflammatory response-related scoring”, “systemic inflammatory response markers”, “Neutrophil-to-lymphocyte ratio”, “Neutrophil-to-platelet ratio”, “Lymphocyte-to-monocyte ratio”, “Glasgow Prognostic Score”, “Neutrophil-Platelet Score”, “Systemic Immune-Inflammation Index”, and “Prognostic Nutrition Index” in clinical studies. Evidence synthesis The Neutrophil-to-Lymphocyte Ratio and the Platelet-to-Lymphocyte Ratio are the ones most extensively investigated in patients with endocrine tumors. Other scores have also been considered in some studies. Several studies focused in finding whether serum inflammatory biomarkers may stratify the endocrine tumor patients’ risk and detect those at risk for developing more aggressive and/or refractory disease, particularly after endocrine surgery. Conclusions In this review, we summarize the current knowledge on the different serum inflammation-based scores and their usefulness in predicting the phenotype, clinical aggressiveness, disease outcomes and prognosis in patients with endocrine tumors. The value of such serum inflammation-based scores in the management of patients with endocrine tumors has been emerging over the last decade. However, further research is necessary to establish useful markers and their cut-offs for routine clinical practice for individual diseases.

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“…Moreover, these ratios have been proposed as potential indicators to differentiate malignant from benign neoplasms in the preoperative period, and predict the prognosis and response to treatment [21][22][23][24][25][26][27]. Some authors proved that preoperative NLR and PLR values may provide effective guidance about long-term outcomes, including the recurrence rate and progression-free survival in craniopharyngiomas and meningiomas [28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte Ratios, and Systemic Immune-Inflammation Index as Potential Biomarkers of Chronic Inflammation in Patients with Newly Diagnosed Acromegaly: A Single-Centre Study

Szydełko

Szydełko-Gorzkowicz

Matyjaszek‐Matuszek

2021

JCM

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Acromegaly is a rare disease caused by overproduction of growth hormone (GH) by a pituitary adenoma, and consequently increased insulin-like growth factor 1 (IGF-1) concentration. The GH/IGF-1 axis and immune cells interactions are hypothesized to be involved in subclinical inflammation. This retrospective study aimed to investigate the differences in neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR) ratios, and systemic immune-inflammation index (SII) in GH-secreting adenomas compared with non-functioning pituitary adenomas (NFPAs) concerning clinical and radiological findings. After evaluation of 665 patients with pituitary tumors, 62 individuals with newly diagnosed acromegaly and 134 with NFPAs were enrolled in the analysis. The control group consisted of 120 healthy individuals. Fifty-eight patients with acromegaly were re-evaluated after medical or surgical therapies. NLR, PLR, SII values, and neutrophil count were significantly higher (p ≤ 0.001), whereas lymphocyte count was lower in acromegaly than in NFPAs (p = 0.001). No significant differences between NFPAs and controls were observed in analyzed ratios. Higher preoperative NLR, PLR, SII values were found in patients who failed to achieve a cure with surgery (p < 0.05). Although NLR, PLR, and SII values were significantly higher in acromegaly, these indices cannot be used to discriminate GH-secreting pituitary tumors from NFPAs. Treatment of acromegaly decreased the value of NLR and SII, but it requires further studies to consolidate the real clinical role of these inflammation-related ratios.

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Impact of neutrophil–lymphocyte ratio on long-term outcome in patients with craniopharyngioma

Cited by 13 publications

References 65 publications

Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Patients With Meningiomas

Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Patients With Meningiomas

Serum Inflammation-based Scores in Endocrine Tumors

Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte Ratios, and Systemic Immune-Inflammation Index as Potential Biomarkers of Chronic Inflammation in Patients with Newly Diagnosed Acromegaly: A Single-Centre Study

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