Serum Inflammation-based Scores in Endocrine Tumors

Marques, Pedro; Vries, Friso de; Dekkers, Olaf M.; Korbonits, Márta; Biermasz, Nienke R.; Pereira, Alberto M.

doi:10.1210/clinem/dgab238

Cited by 25 publications

(19 citation statements)

References 135 publications

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“…THCA accounts for more than 95% of endocrine cancer, and most are well-differentiated arising from follicular epithelial cells [15]. Although THCA patients have better clinical outcomes, a number of patients still develop local recurrence with or without cervical lymph node metastasis or distant metastases [16].…”

Section: Discussionmentioning

confidence: 99%

Increased Expression of Integrin Subunit α3 is Correlated with Worse Recurrence-Free Survival in Thyroid Cancer

Cheng

Zhu

et al. 2021

Preprint

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Objective: To investigate the potential effect of integrin subunit α3 (ITGA3) on thyroid cancer (THCA). Materials and Methods: Based on bioinformatics databases, the expression levels of ITGA3 were firstly analyzed, followed by evaluating the prognostic significance of ITGA3 in THCA patients. Cox regression analysis predicted the independent prognostic factors for THCA. Then, cBioportal and GSCA databases were applied to evaluate genetic alterations of ITGA3. Functional enrichment analysis was conducted using the R package. Finally, the upstream microRNAs of ITGA3 were determined. Results: ITGA3 gene and protein levels were higher in the THCA group than normal group (all P <0.05). And ITGA3 mRNA expression was significantly related to cancer stage and histological subtype (all P <0.01). Moreover, high expression of ITGA3 was associated with poor recurrence-free survival (RFS) of THCA patients in all subgroups (all P <0.01). Cox regression analysis presented that ITGA3 overexpression was an independent prognostic factor for worse RFS in THCA patients. Besides, significant relations were observed between ITGA3 and genetic alterations (FDR <0.01). Functional enrichment analysis indicated ECM-receptor interaction, and cell adhesion molecules were the shared regulatory pathways. We also found that ITGA3 might be the target gene of hsa-miR-3129, hsa-miR-181d, hsa-miR-181b, hsa-miR-199a, and hsa-miR-199b, which were all correlated with THCA patient prognosis. Conclusions: ITGA3 could be a reliable biomarker and promising therapeutic target for improving the diagnosis and clinical outcomes of THCA patients.

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Section: Discussionmentioning

confidence: 99%

Increased Expression of Integrin Subunit α3 is Correlated with Worse Recurrence-Free Survival in Thyroid Cancer

Cheng

Zhu

et al. 2021

Preprint

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“…1). [4][5][6] In recent years, extensive research has revealed the intricate connection between tumors and inflammation. [7][8][9][10] It has been found that the molecular and cellular mechanisms linking inflammation and cancer involve 2 pathways.…”

Section: The Relationship Between Tumors and Inflammationmentioning

confidence: 99%

Advances in systemic immune inflammatory indices in non-small cell lung cancer: A review

Mao,

Cao,

et al. 2024

Medicine

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Lung cancer is one of the most prevalent cancers globally, with non-small cell lung cancers constituting the majority. These cancers have a high incidence and mortality rate. In recent years, a growing body of research has demonstrated the intricate link between inflammation and cancer, highlighting that inflammation and cancer are inextricably linked and that inflammation plays a pivotal role in cancer development, progression, and prognosis of cancer. The Systemic Immunoinflammatory Index (SII), comprising neutrophil, lymphocyte, and platelet counts, is a more comprehensive indicator of the host’s systemic inflammation and immune status than a single inflammatory index. It is widely used in clinical practice due to its cost-effectiveness, simplicity, noninvasiveness, and ease of acquisition. This paper reviews the impact of SII on the development, progression, and prognosis of non-small cell lung cancer.

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“…Elevations in circulating platelet-to-lymphocyte ratios are often associated with inflammation and poor outcomes along with being linked to infections, inflammatory diseases, liver disease and cancer (140)(141)(142)(143)(144)(145)(146). The predictive value indicative of poor outcomes linked to elevated platelet-to-lymphocyte ratios has shown clear associations with liver transplantation, particularly when performed for hepatocellular carcinoma and liver metastasis (147)(148)(149)(150)(151)(152).…”

Section: Platelet-to-lymphocyte Ratiosmentioning

confidence: 99%

The Provocative Roles of Platelets in Liver Disease and Cancer

et al. 2021

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Both platelets and the liver play important roles in the processes of coagulation and innate immunity. Platelet responses at the site of an injury are rapid; their immediate activation and structural changes minimize the loss of blood. The majority of coagulation proteins are produced by the liver—a multifunctional organ that also plays a critical role in many processes: removal of toxins and metabolism of fats, proteins, carbohydrates, and drugs. Chronic inflammation, trauma, or other causes of irreversible damage to the liver can dysregulate these pathways leading to organ and systemic abnormalities. In some cases, platelet-to-lymphocyte ratios can also be a predictor of disease outcome. An example is cirrhosis, which increases the risk of bleeding and prothrombotic events followed by activation of platelets. Along with a triggered coagulation cascade, the platelets increase the risk of pro-thrombotic events and contribute to cancer progression and metastasis. This progression and the resulting tissue destruction is physiologically comparable to a persistent, chronic wound. Various cancers, including colorectal cancer, have been associated with increased thrombocytosis, platelet activation, platelet-storage granule release, and thrombosis; anti-platelet agents can reduce cancer risk and progression. However, in cancer patients with pre-existing liver disease who are undergoing chemotherapy, the risk of thrombotic events becomes challenging to manage due to their inherent risk for bleeding. Chemotherapy, also known to induce damage to the liver, further increases the frequency of thrombotic events. Depending on individual patient risks, these factors acting together can disrupt the fragile balance between pro- and anti-coagulant processes, heightening liver thrombogenesis, and possibly providing a niche for circulating tumor cells to adhere to—thus promoting both liver metastasis and cancer-cell survival following treatment (that is, with minimal residual disease in the liver).

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Serum Inflammation-based Scores in Endocrine Tumors

Cited by 25 publications

References 135 publications

Increased Expression of Integrin Subunit α3 is Correlated with Worse Recurrence-Free Survival in Thyroid Cancer

Increased Expression of Integrin Subunit α3 is Correlated with Worse Recurrence-Free Survival in Thyroid Cancer

Advances in systemic immune inflammatory indices in non-small cell lung cancer: A review

The Provocative Roles of Platelets in Liver Disease and Cancer

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