Impact of neoadjuvant chemotherapy on breast reconstruction.

Hu, Yan; Weeks, Christine; Chi, Hyung In; Dodgion, Christopher; Golshan, Mehra; Chun, Yong Soon; Hassett, M. J.; Gu, Xiaohong; Lipsitz, S.; Greenberg, Caprice C.

doi:10.1200/jco.2010.28.15_suppl.6135

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…65 66 A retrospective review (n=665) found that patients receiving neo-adjuvant chemotherapy were less likely to undergo immediate reconstruction and more likely to undergo delayed reconstruction than those receiving adjuvant chemotherapy. 67 Evidence about whether immediate breast reconstruction delays adjuvant chemotherapy (systemic cancer directed treatment given after completion of definitive surgery and before recurrence) is conflicting; most of the studies were single institution ones, with small cohorts. 66 68-72 One large (n=3643) multicentre cohort study found that immediate breast reconstruction was associated with a modest, but significant, delay in starting treatment, particularly in patients with a high body mass index (>35).…”

Section: Does Chemotherapy Affect Breast Reconstruction?mentioning

confidence: 99%

Post-mastectomy breast reconstruction

Thiruchelvam

McNeill

Jallali

et al. 2013

BMJ

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tion options with patients, irrespective of whether they are available locally. 6 Fifty three per cent of women having surgery for breast cancer will undergo mastectomy (box 1). 7 8 In the UK and United States, bilateral mastectomy is increasingly being used for risk reduction in BRCA carriers, for those with a high risk of developing breast cancer (lifetime risk of 30%), or as a planned management strategy for unilateral cancer (fig 1, bmj.com). 9-15 In general, bilateral mastectomy is associated with a higher rate of breast reconstruction. A recent Cochrane review showed that bilateral prophylactic (risk reduction) mastectomy reduced the incidence of, and death from, breast cancer, but it highlighted that more rigorous prospective studies are needed to assess absolute risk reduction. 16 The review also found that although contralateral prophylactic (risk reduction) mastectomy decreases the incidence of cancer in the contralateral breast, it is unclear whether, and for whom, this practice improves survival. 16 How is a mastectomy performed?When performing a mastectomy, the anatomical (oncological) plane between breast tissue and subcutaneous fat needs to be identified. It is, however, impossible to remove all breast tissue because the oncological plane is not uniform throughout the breast. A standard (simple) mastectomy removes the breast skin envelope, but a skin sparing mastectomy preserves the breast skin envelope Breast cancer is the most common cancer in women, with almost 1.38 million new cases a year worldwide; it accounts for 23% of all cancers and 14% of deaths from cancer. 1 However, mortality from breast cancer is d eclining-increasing numbers of women are long term survivors (>5 years) (currently 549 000 in the United K ingdom). 2 3 Surgery remains a mainstay of treatment, either breast conservation or mastectomy, but any breast surgery can greatly alter breast aesthetics and body image.Breast reconstruction restores breast symmetry after a mastectomy by creating a breast mound, similar in size, shape, contour, and "out of bra position" to the contralateral breast. In England and Wales in 2002, about 10% of women had immediate breast reconstruction; by 2009 this had risen to 21%. 4 Post-mastectomy breast reconstruction is associated with improved body image, quality of life, self confidence, and wellbeing. 5 In this review, we outline the indications for breast reconstruction along with the timing and techniques available to patients after mastectomy. What is post-mastectomy breast reconstruction?Breast reconstruction is a surgical procedure that restores shape to the breast after mastectomy. Although it will not re-create the exact look and feel of a natural breast, it aims to create a breast mound contour similar to that before mastectomy. When, and to whom, should breast reconstruction be offered?In 2009 the National Institute for Health and Clinical Excellence (NICE) revised guidance on improving breast cancer outcomes. It recommended discussing immediate reconstruction with all patients ha...

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Section: Does Chemotherapy Affect Breast Reconstruction?mentioning

confidence: 99%

Post-mastectomy breast reconstruction

Thiruchelvam

McNeill

Jallali

et al. 2013

BMJ

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“…Recent French report suggests that Skin-Sparing Mastectomy and reconstruction with a latissimus dorsi flap could be safely performed after neoadjuvant chemo-and radiotherapy, with an acceptable rate of flap necrosis in a selected group of patients (7). Patients who receive neoadjuvant chemotherapy are less likely to undergo immediate reconstruction, even though they are no more likely to undergo delayed reconstruction than patients receiving adjuvant chemotherapy (8,9). Also it has been shown that premature removal of a tissue expander occurs more commonly in patients treated with neoadjuvant or adjuvant chemotherapy and is most commonly observed 2-3 months after placement (10).…”

Section: Chemotherapymentioning

confidence: 99%

Impact of different type of cancer treatment on the effectiveness of breast reconstruction

et al. 2016

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For women undergoing mastectomy as part of their breast cancer treatment, breast reconstruction is an important part of therapy. However, neoadjuvant, adjuvant treatments as well as other patient-related factors can compromise the results of breast reconstruction techniques. In this article we have reviewed current approaches to the management of complications and risks that neoadjuvant and adjuvant therapies pose on breast reconstruction after mastectomy for breast cancer. Non-treatment related factors influencing reconstruction techniques were reviewed as well.

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Impact of neoadjuvant chemotherapy on breast reconstruction.

Cited by 2 publications

References 27 publications

Post-mastectomy breast reconstruction

Post-mastectomy breast reconstruction

Impact of different type of cancer treatment on the effectiveness of breast reconstruction

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