Impact of n-3 polyunsaturated fatty acids in predicting ischemia/reperfusion injury and progression of myocardial damage after reperfusion in patients with ST-segment elevation acute myocardial infarction

Arakawa, Kentaro; Himeno, Hideo; Kirigaya, Jin; Otomo, Fumie; Matsushita, Kensuke; Nakahashi, Hidefumi; Shimizu, Satoru; Nitta, Manabu; Yano, Hideto; Endo, Mitsuaki; Kimura, Kazuo; Umemura, Satoshi

doi:10.1016/j.jjcc.2015.03.009

Cited by 9 publications

(8 citation statements)

References 43 publications

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“…[1][2][3][4] Fish oil includes n-3 polyunsaturated fatty acids (PUFAs), among which eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are known to be inversely associated with the extent of atherosclerosis, cardiovascular events, and mortality. [5][6][7][8][9][10][11][12] …”

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confidence: 99%

Relationship between n-3 Polyunsaturated Fatty Acids and Extent of Vessel Disease in Patients with ST Elevation Myocardial Infarction

et al. 2017

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SummaryA relationship between serum polyunsaturated fatty acids (PUFAs) and cardiovascular disease has been reported; however, the existence of a relationship between serum PUFAs and extent of vessel disease (VD) in patients with ST elevation myocardial infarction (STEMI) remains unclear.Between July 2011 and June 2015, 866 consecutive STEMI patients underwent emergent percutaneous coronary intervention, 507 of whom were enrolled and classified into three groups according to the initial angiograms: 1VD, 294 patients; 2VD, 110 patients; and 3VD/left main trunk disease (LMTD), 103 patients. Serum levels of PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid, and other laboratory data during hospitalization were evaluated.The serum EPA level in the 3VD/LMTD group was significantly lower than that in the 1VD group (55.5 ± 22.1 versus 66.2 ± 28.7, P = 0.002) and was slightly lower than that in the 2VD group (55.5 ± 22.1 versus 65.2 ± 28.9, P = 0.0167). Multivariate adjustment analysis revealed that age !70 years (odds ratio, 1.72; 95% confidence interval, 1.03-2.89; P = 0.038) and a low serum EPA level (odds ratio, 0.98; 95% confidence interval, 0.99-1.00; P = 0.023) were independent risk factors for 3VD/LMTD, while a low serum DHA level was not.A low serum EPA level may be more strongly related than a low serum DHA level to the extent of VD in STEMI patients. Age !70 years and a low serum EPA level may be independent risk factors for 3VD/LMTD.(Int Heart J 2017; 58: 868-873) Key words: Eicosapentaenoic acid, Docosahexaenoic acid, Mulivessel disease, Acute coronary syndrome, Cardiovascular disease A n association between fish intake and risk of cardiovascular disease has been demonstrated in several epidemiological studies and clinical trials.

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confidence: 99%

Relationship between n-3 Polyunsaturated Fatty Acids and Extent of Vessel Disease in Patients with ST Elevation Myocardial Infarction

et al. 2017

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“…increase in the EFA decrease in the NEFA and AA (5,6,11,31) myocardial infarction serum GC total DHA+EPA profile DHA+EPA profile significantly correlated with the size of ischemia (40) …”

Section: Uflc-ms/ms Lc-ei-ms Gc-ms Gc-fid Arachidonic Acids (C20)mentioning

confidence: 94%

“…Results have shown a better recovery at patients having n-3-PUFA supplements than controls. In the same time, n-3 PUFA have proved their cardioprotective properties and the total serum levels of EPA and DHA can be used as predictors for the level of ischemia after myocardia reperfusion (40).…”

Section: Potential Clinical Utility Of Fatty Acids Profile Analysismentioning

confidence: 98%

“…Arakawa et al (40) have pointed out the importance of n-3 PUFA intake, their cardioprotective properties and have showed that the total serum levels of DHA and EPA can be preman spectroscopy (33,38) can be used for the analysis of fatty acids. These methods, coupled with the multivariate analysis of spectral data can give rapid quantitative information about the analyzed sample (38).…”

Section: Alternative Analitical Techniquesmentioning

confidence: 99%

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Recent developments in fatty acids profile determination in biological samples - a review

Tiuca

Nagy

Oprean

2015

Revista Romana De Medicina De Laborator

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“…In this issue of the Journal of Cardiology, the findings by Arakawa et al may stimulate renewed interest in the clinical setting [3]. The main finding was that lower n-3 polyunsaturated fatty acid (n-3 PUFA) levels can predict incidence of reperfusion injury after primary PCI to AMI patients.…”

mentioning

confidence: 99%

Protective effects of n-3 polyunsaturated fatty acids levels in patients with acute myocardial infarction – A new target to prevent reperfusion injury

Ishii

Murohara

2015

Journal of Cardiology

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Impact of n-3 polyunsaturated fatty acids in predicting ischemia/reperfusion injury and progression of myocardial damage after reperfusion in patients with ST-segment elevation acute myocardial infarction

Abstract: Serum level of n-3 PUFAs before PCI may be a predictor of I/R injury and the resultant extent of myocardial damage. These findings suggest a protective effect of serum n-3 PUFAs on ischemic myocardium.

Cited by 9 publications

References 43 publications

Relationship between n-3 Polyunsaturated Fatty Acids and Extent of Vessel Disease in Patients with ST Elevation Myocardial Infarction

Relationship between n-3 Polyunsaturated Fatty Acids and Extent of Vessel Disease in Patients with ST Elevation Myocardial Infarction

Recent developments in fatty acids profile determination in biological samples - a review

Protective effects of n-3 polyunsaturated fatty acids levels in patients with acute myocardial infarction – A new target to prevent reperfusion injury

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