Protective effects of n-3 polyunsaturated fatty acids levels in patients with acute myocardial infarction – A new target to prevent reperfusion injury

Ishii, Hideki; Murohara, Toyoaki

doi:10.1016/j.jjcc.2015.03.011

Cited by 2 publications

(2 citation statements)

References 13 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[1][2][3][4] Fish oil includes n-3 polyunsaturated fatty acids (PUFAs), among which eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are known to be inversely associated with the extent of atherosclerosis, cardiovascular events, and mortality. [5][6][7][8][9][10][11][12] …”

mentioning

confidence: 99%

Relationship between n-3 Polyunsaturated Fatty Acids and Extent of Vessel Disease in Patients with ST Elevation Myocardial Infarction

et al. 2017

View full text Add to dashboard Cite

SummaryA relationship between serum polyunsaturated fatty acids (PUFAs) and cardiovascular disease has been reported; however, the existence of a relationship between serum PUFAs and extent of vessel disease (VD) in patients with ST elevation myocardial infarction (STEMI) remains unclear.Between July 2011 and June 2015, 866 consecutive STEMI patients underwent emergent percutaneous coronary intervention, 507 of whom were enrolled and classified into three groups according to the initial angiograms: 1VD, 294 patients; 2VD, 110 patients; and 3VD/left main trunk disease (LMTD), 103 patients. Serum levels of PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid, and other laboratory data during hospitalization were evaluated.The serum EPA level in the 3VD/LMTD group was significantly lower than that in the 1VD group (55.5 ± 22.1 versus 66.2 ± 28.7, P = 0.002) and was slightly lower than that in the 2VD group (55.5 ± 22.1 versus 65.2 ± 28.9, P = 0.0167). Multivariate adjustment analysis revealed that age !70 years (odds ratio, 1.72; 95% confidence interval, 1.03-2.89; P = 0.038) and a low serum EPA level (odds ratio, 0.98; 95% confidence interval, 0.99-1.00; P = 0.023) were independent risk factors for 3VD/LMTD, while a low serum DHA level was not.A low serum EPA level may be more strongly related than a low serum DHA level to the extent of VD in STEMI patients. Age !70 years and a low serum EPA level may be independent risk factors for 3VD/LMTD.(Int Heart J 2017; 58: 868-873) Key words: Eicosapentaenoic acid, Docosahexaenoic acid, Mulivessel disease, Acute coronary syndrome, Cardiovascular disease A n association between fish intake and risk of cardiovascular disease has been demonstrated in several epidemiological studies and clinical trials.

show abstract

mentioning

confidence: 99%

Relationship between n-3 Polyunsaturated Fatty Acids and Extent of Vessel Disease in Patients with ST Elevation Myocardial Infarction

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Therefore, our data suggest that insufficient secondary prevention at admission combined with suboptimal in-hospital treatment may contribute to the dismal outcome. The use of new cardioprotective strategies, such as n-3 polyunsaturated fatty acids, may reduce plaque burden and stabilize plaque components leading to a reduced rate of complications [24]. It has been reported that the symptoms of recurrent infarction were not similar to those of the first infarction [25].…”

Section: Discussionmentioning

confidence: 99%

Treatment and outcomes of patients with recurrent myocardial infarction: A prospective observational cohort study

Radovanovic

Maurer

Bertel

et al. 2016

Journal of Cardiology

View full text Add to dashboard Cite

show abstract

Protective effects of n-3 polyunsaturated fatty acids levels in patients with acute myocardial infarction – A new target to prevent reperfusion injury

Cited by 2 publications

References 13 publications

Relationship between n-3 Polyunsaturated Fatty Acids and Extent of Vessel Disease in Patients with ST Elevation Myocardial Infarction

Relationship between n-3 Polyunsaturated Fatty Acids and Extent of Vessel Disease in Patients with ST Elevation Myocardial Infarction

Treatment and outcomes of patients with recurrent myocardial infarction: A prospective observational cohort study

Contact Info

Product

Resources

About