Impact of Multiprobiotics on the Content of Tba-Reactive Substances in the Blood Serum and Mucous Membranes of the Stomach and Colon in Rats With Long-Term Gastric Hypochlorhydria

Pylypenko, S. V.; Koval, A. A.; Макарчук, Владимир

doi:10.26724/2079-8334-2018-3-65-218-222

Cited by 2 publications

(2 citation statements)

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“…The data we obtained earlier on the significant increase in the content of TBA-reactive substances and NO products is the evidence of oxidative / nitrosative stress development in the mucous membrane of the stomach under prolonged gastric hypochlorohydria [1].…”

Section: Discussionsupporting

confidence: 52%

“…A special feature of many digestive tract organs' diseases is their recurrent nature, as well as their treatment failure in a number of diseases and impossibility to achieve complete clinical remission. Thus, in chronic stomach erosions only half of cases manage to achieve a complete recovery [1]. As for atrophic gastritis with hypo-or anacidity of gastric juice, the picture is even worse.…”

Section: Introductionmentioning

confidence: 99%

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Activity of Superoxide Dismutase and Catalase in the Gastric Mucosa of Rats Under the Prolonged Administration of Omeprazol and Combination of Omeprazole and Multiprobiotics

2021

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The aim: Of the study was to study the activity of superoxide dismutase and catalase in the gastric mucosa of rats under long-term administration of omeprazole and combined administration of omeprazole with Symbiter and Apibact multiprobiotics. Materials and methods: The study was carried out on 40 white non-linear male rats with an initial weight of 160-180 g. All animals were divided into 4 groups. Group I was the control. Group II was administered omeprazole once a day within the period of 28 days. Group III was administered a combination of omeprazole and Symbiter® multiprobiotic. Group IV was administered a combination of omeprazole and Apibact® multiprobiotic. The activity of superoxide dismutase in cells was determined by Chevars et al. . The catalase activity in cells was determined by Korolyuk et al. . Statistical processing of the results was performed using the “Statistica 7.0” software. Results: The activity of SOD and catalase in the gastric mucosa of rats after 28 days of omeprazole administration increased compared to the control. Probiotics reduced the activity of SOD compared to the group of rats where omeprazole only was administered. The catalase activity in the gastric mucosa of rats which were jointly administered omeprazole and multiprobiotics for 28 days did not statistically significantly differ from the similar index in the control group. Conclusions: Prolonged gastric juice hypochlorhydria led to depletion of antioxidant protection enzymes. Multiprobiotics reduced the manifestation of the inflammatory process in the gastric mucosa.

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Section: Discussionsupporting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Activity of Superoxide Dismutase and Catalase in the Gastric Mucosa of Rats Under the Prolonged Administration of Omeprazol and Combination of Omeprazole and Multiprobiotics

2021

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Antioxidant protection enzyme activity in the blood serum and large intestinal mucosa of rats with prolonged gastric hypochlorhydria and given multiprobiotics

Pylypenko

Koval

2019

Regul. Mech. Biosyst.

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The activity of antioxidant protection enzymes in the blood serum and colon mucosa in rats was studied under the conditions of 28-days administration of omeprazole on its own and omeprazole together with multiprobiotics "Symbiter" and "Apibact". Physiological and biochemical study methods were applied. It was found that after omeprazole administration, the activity of superoxide dismutase in the blood serum decreased, and the activity of catalase increased compared to the control. With the co-administration of omeprazole and multiprobiotics, the activity of superoxide dismutase increased compared to the group of rats that received omeprazole only during the same time, but remained less compared to the control group. The content of reduced glutathione in the blood serum of rats after administration of omeprazole decreased, the activity of glutathione peroxidase and glutathione transferase increased, and the activity of glutathione reductase decreased compared to the control. With co-administration of omeprazole and multiprobiotics, the serum RG content was at the control level, the activity of glutathione reductase exceeded the control values. The activity of glutathione reductase decreased compared to the group receiving omeprazole only. The activity of glutathione reductase increased and did not differ from the control values. In the colon mucosa, superoxide dismutase and catalase activity decreased compared to control. With the combined administration of omeprazole and multiprobiotics, superoxide dismutase and catalase activity increased and even exceeded the control values. With the administration of omeprazole, the reduced glutathione content in the colon mucosa was lower than that in the control. The activity of glutathione peroxidase increased and glutathione transferase and activity of glutathione reductase decreased compared to the control. With co-administration of omeprazole and multiprobiotics to rats, the reduced glutathione content increased compared to the group of rats administered omeprazole only, and even exceeded that in the control.

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Impact of Multiprobiotics on the Content of Tba-Reactive Substances in the Blood Serum and Mucous Membranes of the Stomach and Colon in Rats With Long-Term Gastric Hypochlorhydria

Cited by 2 publications

References 3 publications

Activity of Superoxide Dismutase and Catalase in the Gastric Mucosa of Rats Under the Prolonged Administration of Omeprazol and Combination of Omeprazole and Multiprobiotics

Activity of Superoxide Dismutase and Catalase in the Gastric Mucosa of Rats Under the Prolonged Administration of Omeprazol and Combination of Omeprazole and Multiprobiotics

Antioxidant protection enzyme activity in the blood serum and large intestinal mucosa of rats with prolonged gastric hypochlorhydria and given multiprobiotics

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