Impact of molar incisor hypomineralization on quality of life in children with early mixed dentition: A hierarchical approach

Portella, Paula Dresch; Menoncin, Bruna Letícia Vessoni; Souza, Juliana Feltrin de; Menezes, José Vitor Nogara Borges de; Fraiz, Fabián Calixto; Assunção, Luciana Reichert da Silva

doi:10.1111/ipd.12482

Cited by 62 publications

(88 citation statements)

References 22 publications

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“…In a recent study, it has been reported that MIH has an impact on all areas among Colombian children aged 7‐10 years . Portella et al similarly reported that the effect of MIH on OHRQoL was in the oral symptoms of the child.…”

Section: Discussionmentioning

confidence: 97%

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Conceptual modelling of the factors affecting oral health‐related quality of life in children: A path analysis

Buldur

Güvendi

2019

Int J Paed Dentistry

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Background It is important to understand the interaction of various predictors with oral health‐related quality of life (OHRQoL) to better design effective interventions to improve OHRQoL. Aim The aim of this study was to develop and validate a conceptual model evaluating the factors affecting the OHRQoL in children. Design The study group consisted of 754 parent‐child dyads. The data collection tools were a socio‐demographic data form, the Early Childhood Oral Health Impact Scale (ECOHIS), Corah Dental Anxiety Scale (C‐DAS), Children's Fear Survey Schedule‐Dental Subscale (CFSS‐DS), and an oral and dental health examination form. A conceptual model was developed to examine the factors affecting OHRQoL in children consisting of four endogenous and four exogenous variables. Path analysis was used to test the compatibility of the conceptual model. Results OHRQoL was associated with parental socio‐economic status (β = −0.12; P < .001), dental anxiety (β = −0.15; P < .001), and oral health behaviours (β = −0.13; P < .001). Although parental dental anxiety had the strongest direct effect on OHRQoL, children's oral health behaviours had the strongest indirect effect. Conclusions This study revealed a valid demonstrable path of association between parental socio‐economic status, dental anxiety, childhood dental anxiety, oral health behaviours, and OHRQoL.

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Section: Discussionmentioning

confidence: 97%

“…MIH can impair OHRQoL by causing functional limitations . It was reported that children with severe MIH showed a more negative impact on OHRQoL regarding oral symptoms and functional limitation areas than those without MIH .…”

Section: Discussionmentioning

confidence: 99%

Conceptual modelling of the factors affecting oral health‐related quality of life in children: A path analysis

Buldur

Güvendi

2019

Int J Paed Dentistry

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“…The sample consisted of 356 school children, which were randomly selected from a representative population [58] from the city of Curitiba public schools. To ensure accurate population representation, two-stage cluster sampling was performed.…”

Section: Cohort From Curitiba Brazil (Federal University Of Paraná):mentioning

confidence: 99%

Gene-environment interaction in molar-incisor hypomineralization

et al. 2021

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Molar incisor hypomineralization (MIH) is an enamel condition characterized by lesions ranging in color from white to brown which present rapid caries progression, and mainly affects permanent first molars and incisors. These enamel defects usually occur when there are disturbances during the mineralization or maturation stage of amelogenesis. Both genetic and environmental factors have been suggested to play roles in MIH’s development, but no conclusive risk factors have shown the source of the disease. During head and neck development, the interferon regulatory factor 6 (IRF6) gene is involved in the structure formation of the oral and maxillofacial regions, and the transforming growth factor alpha (TGFA) is an essential cell regulator, acting during proliferation, differentiation, migration and apoptosis. In this present study, it was hypothesized that these genes interact and contribute to predisposition of MIH. Environmental factors affecting children that were 3 years of age or older were also hypothesized to play a role in the disease etiology. Those factors included respiratory issues, malnutrition, food intolerance, infection of any sort and medication intake. A total of 1,065 salivary samples from four different cohorts were obtained, and DNA was extracted from each sample and genotyped for nine different single nucleotide polymorphisms. Association tests and logistic regression implemented in PLINK were used for analyses. A potential interaction between TGFA rs930655 with all markers tested in the cohort from Turkey was identified. These interactions were not identified in the remaining cohorts. Associations (p<0.05) between the use of medication after three years of age and MIH were also found, suggesting that conditions acquired at the age children start to socialize might contribute to the development of MIH.

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“…e association between the presence of MIH and quality of life has been previously reported in some studies both in Brazil [12,13] and in other countries, such as Colombia [1] and Mexico [14]. However, given the existence of particularities in the occurrence and comorbidities associated with MIH [5,8,15,16], this relationship needs to be investigated in more detail, considering its cultural and socioeconomic diversities [17].…”

Section: Introductionmentioning

confidence: 94%

Incisor Molar Hypomineralization and Quality of Life: A Population-Based Study with Brazilian Schoolchildren

Fernandes

Laureano

Farias

et al. 2021

International Journal of Dentistry

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Aim. To assess the impact of incisor molar hypomineralization (MIH) on oral health-related quality of life (OHRQoL) according to the perception of students and their parents/caregivers. Materials and Methods. This is a cross-sectional population-based study with 463 Brazilian students aged 11–14 years. OHRQoL was measured using the Child Perceptions Questionnaire (B-CPQ11-14ISF: 16) applied to students and the short version of the Parental-Caregiver Perceptions Questionnaire (B-P-CPQ) applied to parents/caregivers. The diagnosis of MIH followed the European Academy of Paediatric Dentistry criteria modified in 2019. Caries experience (ICDAS II), malocclusion (DAI), and socioeconomic and demographic factors were assessed as confounding factors for impact on OHRQoL. Cluster analysis was carried out to dichotomize the negative impact into greater and lesser impact. The chi-square test and Poisson regression were performed ( p < 0.05 ) to verify associations between quality of life and MIH, adjusted for confounding variables. Results. The prevalence of MIH was 10.8%. Multivariate regression demonstrated that caries experience was the only oral disease that impacted OHRQoL according to students’ self-perception in the functional limitation domain (PR = 1.82; 95% CI = 1.20–2.77) and in the total questionnaire score (PR = 1.59; 95% CI = 1.00–2.51). However, according to the perception of parents/caregivers, in addition to caries experience, which affected OHRQoL in the oral symptoms (PR = 3.57; 95% CI = 1.71–7.414) and emotional well-being domains (PR = 1.71; 95% CI = 1.08–2.69), as well as in the total B-P-CPQ score (PR = 1.67; 95% CI = 1.01–2.76), malocclusion also affected OHRQoL in the social well-being domain (PR = 1.50; 95% CI = 1.07–2.10) and in the total questionnaire score (PR = 1.54; 95% CI = 1.11–2.15). Conclusion. According to students and their parents/caregivers’ perception, incisor molar hypomineralization did not influence OHRQoL of the studied sample.

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Impact of molar incisor hypomineralization on quality of life in children with early mixed dentition: A hierarchical approach

Cited by 62 publications

References 22 publications

Conceptual modelling of the factors affecting oral health‐related quality of life in children: A path analysis

Conceptual modelling of the factors affecting oral health‐related quality of life in children: A path analysis

Gene-environment interaction in molar-incisor hypomineralization

Incisor Molar Hypomineralization and Quality of Life: A Population-Based Study with Brazilian Schoolchildren

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