Impact of modulus of elasticity of silicone hydrogel contact lenses on meibomian glands morphology and function

Iqbal, Asif; Thomas, Rinu; Mahadevan, Rajeswari

doi:10.1080/08164622.2021.1887703

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…This is in opposition to the results found in previous studies, which found lower tear meniscus [ 21 , 22 ] and more dry eye symptoms [ 6 , 9 , 22 , 34 ], bulbar redness [ 18 ] and tear film instability [ 9 , 14 , 21 , 22 , 34 , 48 ] in CL wearers as compared to non-wearers. In agreement with the results found in the present study, Arita et al [ 14 ], Iqbal et al [ 51 ] and Machalińska et al [ 18 ] did not find differences in tear volume between CL and non-CL wearers. Likewise, other authors did not find statistically significant differences between CL and non-CL wearers for OSDI [ 18 ], break-up time [ 6 , 18 , 45 ], TMH, bulbar redness and tear osmolarity [ 45 ].…”

Section: Discussionsupporting

confidence: 93%

The Effects of Soft Contact Lens Wear on The Tear Film and Meibomian Gland Drop-Out and Visibility

García‐Marqués

Talens‐Estarelles

García‐Lázaro

et al. 2022

Life

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As contact lens (CL) wear affects the ocular surface, this cross-sectional study aims to assess the effects of soft CL wear and its duration on the tear film and meibomian gland (MG) drop-out and visibility. Thirty non-CL wearers (22.5 ± 2.3 years) and twenty-four soft CL wearers (23.8 ± 2.2 years) participated in this study. The Keratograph 5M was used to assess the ocular surface. CL users were surveyed on years of CL wear and hours per week. MG visibility was assessed using a previously developed method based on analysing pixel intensity of meibographies. The CL group showed higher gland drop-out (p < 0.001) and lower gland visibility (p < 0.022). Gland drop-out was independently associated with CL wear (p = 0.006). When gland drop-out was excluded, the relative energy of pixel intensity values showed an independent association with CL wear (p = 0.005). Prolonged hours of CL wear were associated with higher dry eye symptoms and entropy of MGs (p < 0.029). A reduction in non-invasive keratograph break-up time was associated with using CLs for ≥8 years (p = 0.030). Overall, gland drop-out was higher and gland visibility lower in soft CL wearers. New gland visibility metrics might help to assess MGs in soft CL wearers quickly and objectively.

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Section: Discussionsupporting

confidence: 93%

The Effects of Soft Contact Lens Wear on The Tear Film and Meibomian Gland Drop-Out and Visibility

García‐Marqués

Talens‐Estarelles

García‐Lázaro

et al. 2022

Life

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“…This is a measure of contact lenses’ polymer stiffness, flexibility, or resistance to deformation [ 84 ]. It represents the ratio of stress to strain (load per unit cross-sectional area to local elongation) [ 85 ].…”

Section: Materials For Contact Lensesmentioning

confidence: 99%

Drug-Modified Contact Lenses—Properties, Release Kinetics, and Stability of Active Substances with Particular Emphasis on Cyclosporine A: A Review

Rykowska,

Michałkiewicz,

Nowak

et al. 2024

Molecules

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The following review focuses on the manufacturing and parameterizing of ocular drug delivery systems (DDS) using polymeric materials to create soft contact lenses. It discusses the types of drugs embedded into contact lenses, the various polymeric materials used in their production, methods for assessing the mechanical properties of polymers, and techniques for studying drug release kinetics. The article also explores strategies for investigating the stability of active substances released from contact lenses. It specifically emphasizes the production of soft contact lenses modified with Cyclosporine A (CyA) for the topical treatment of specific ocular conditions. The review pays attention to methods for monitoring the stability of Cyclosporine A within the discussed DDS, as well as investigating the influence of polymer matrix type on the stability and release of CyA.

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“…This disease was defined by the 2011 International Workshop on MGD as "a chronic, diffuse abnormality of the Meibomian glands, commonly characterized by terminal duct obstruction and/or qualitative/quantitative changes in the glandular secretion" [15]. Some studies concluded that soft and rigid contact lens wear may potentiate meibomian gland drop-out, alter gland morphology such as length and width, alter meibum expressibility and quality, and induce dry eye symptoms, ultimately classified as MGD [22][23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Assessment of meibomian gland drop-out and visibility through a new quantitative method in scleral lens wearers: A one-year follow-up study

García‐Marqués

Macedo-de-Araújo

Cerviño

et al. 2023

Contact Lens and Anterior Eye

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To validate a previously developed algorithm based on the visibility of meibomian gland images obtained with Cobra fundus camera and to assess the changes in meibomian glands in scleral lens wearers over one year of lens wear. Methods: Infrared meibography was obtained from the upper eyelid using the Cobra fundus camera in forty-three volunteers (34.2 ± 10.1 years). Meibographies were classified into 3 groups: Group 1 = good subjective gland visibility and gland drop-out < 1/3 of the total area; Group 2 = low visibility and gland drop-out < 1/3; and Group 3 = low visibility and gland drop-out > 1/3. Meibomian gland visibility metrics were then calculated using the developed algorithm from the pixel intensity values of meibographies. Repeatability of new metrics and their correlations with gland drop-out were assessed. Meibographies and ocular symptoms were also assessed after 1 year of scleral lens wear in 29 subjects. Results: Gland drop-out percentage was not statistically different between groups 1 and 2 (p = 0.464). Nevertheless, group 1 showed higher grey pixel intensity values than the other groups. Statistically significant correlations were found between gland visibility metrics and gland drop-out percentage. Repeatability was acceptable for all metrics, coefficient of variation achieving values between 0.52 and 3.18. While ocular symptoms decreased with scleral lens wear (p < 0.001), no statistically significant differences were found in gland drop-out percentage (p = 0.157) and gland visibility metrics (p > 0.217). Conclusions: The proposed method can assess meibomian gland visibility in an objective and repeatable way. Scleral lens wear appears to not adversely affect meibomian gland drop-out and visibility while might improve dry eye symptoms after one year of lens wear. These preliminary results should be confirmed with a control group.

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Impact of modulus of elasticity of silicone hydrogel contact lenses on meibomian glands morphology and function

Cited by 5 publications

References 33 publications

The Effects of Soft Contact Lens Wear on The Tear Film and Meibomian Gland Drop-Out and Visibility

The Effects of Soft Contact Lens Wear on The Tear Film and Meibomian Gland Drop-Out and Visibility

Drug-Modified Contact Lenses—Properties, Release Kinetics, and Stability of Active Substances with Particular Emphasis on Cyclosporine A: A Review

Assessment of meibomian gland drop-out and visibility through a new quantitative method in scleral lens wearers: A one-year follow-up study

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