Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population

Погорєлова, Оксана Сергіївна; Korniienko, Viktoriia; Chumachenko, Yaroslav; Obukhova, Olha Anatoliivna; Martsovenko, Igor; Harbuzova, V. Yu.

doi:10.1155/2022/2067632

Cited by 5 publications

(5 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[13][14][15] Even though MMP-9 belongs to the family of metalloproteinase and is considered to be widely studied, researchers continue to study the role of this enzyme in atherosclerosis, ACS, MI and other cardiovascular diseases (CVD). [16][17][18][19] The most recent studies continue to investigate the MMP-9 role as a player in pathways of myocardial injury and its place in the field of prognostic markers in cardiovascular pathology. [20][21][22][23] And its role is under investigation not only in cardiovascular pathology, but also in chronic Chagas disease, ocular pathology, ischemic stroke, in diabetes.…”

Section: Discussionmentioning

confidence: 99%

Matrix metallopeptidase-9 prognostic role in STEMI patients after percutaneous coronary intervention (PCI) in one-year follow-up period

Kopytsya¹,

Нilоva²,

Rodionova³

et al. 2023

Cor Vasa

View full text Add to dashboard Cite

Použití matrixové metalopeptidázy-9 (MMP-9) u pacientů s akutním infarktem myokardu s elevacemi úseku ST (STEMI) po perkutánní koronární intervenci (PCI) jako prognostického indikátoru má mnoho mezer a lékařská komunita s tím má velmi omezené zkušenosti. Cílem studie bylo zhodnotit prognostickou roli MMP-9 u pacientů se STEMI po úspěšné revaskularizaci během 12měsíčního období sledování. Materiál a metoda: Do studie bylo zařazeno 88 pacientů, kteří splnili kritéria pro zařazení a neměli žádná vylučovací kritéria, jimž byl diagnostikován STEMI a podstoupili primární PCI. Mužů bylo 66 (75,0 %), s průměrným věkem 60,84 ± 9,68 roku. Doba sledování činila 12 měsíců. Byl použit složený cílový ukazatel, který zahrnoval výskyt srdečního selhání, které si vyžádalo hospitalizaci, úmrtí z kardiovaskulárních příčin, recidivující infarkt myokardu, akutní cerebrovaskulární příhodu. Koncentrace MMP-9 byla stanovena pomocí ELISA. Výsledky: Kaplanova-Meierova analýza křivek ukázala významnou souvislost mezi zvýšenou MMP-9 a studovaným složeným cílovým ukazatelem, p = 0,0229. Pacienti s koncentracemi MMP-9 > 201,7 ng/ml měli signifi kantně více cílových ukazatelů. Jednorozměrná regresní analýza zjistila, že MMP-9 byla indikována jako nezávislá proměnná pro nepříznivý výsledek s poměrem šancí (OR):

show abstract

Section: Discussionmentioning

confidence: 99%

Matrix metallopeptidase-9 prognostic role in STEMI patients after percutaneous coronary intervention (PCI) in one-year follow-up period

Kopytsya¹,

Нilоva²,

Rodionova³

et al. 2023

Cor Vasa

View full text Add to dashboard Cite

show abstract

“…In addition, some researchers found that HSP27 expression was increased in single nucleated cells of human peripheral blood and significantly correlated with the severity of CAD, rendering it a potential prognostic marker (29). Matrix metalloproteinase-9 (MMP9), an important member of MMP, is involved in the whole process of AS and high MMP9 expression is associated with plaque instability (30,31). In a subsequent analysis, these genes were found to be positively or negatively correlated with some immune cells, suggesting that the genes and the immune microenvironment influence each other, but the exact mechanism is unknown.…”

Section: Nk Cells Activated Mast Cells Resting T Cells Gamma Delta Ne...mentioning

confidence: 99%

Differential expression and significance of peripheral blood genes in coronary artery heart disease

Nong¹,

Ma²,

Luo³

et al. 2022

J Thorac Dis

View full text Add to dashboard Cite

Background:The peripheral blood gene expression profile of patients with coronary artery disease (CAD) has not been fully resolved. The aim of this study was to further analyze the peripheral blood transcriptome information of CAD patients and to uncover key genes and regulatory mechanisms in the pathogenesis and disease progression of CAD. Methods:The Gene Expression Omnibus (GEO) database was applied to screen out differentially expressed genes (DEGs) in the peripheral blood of CAD patients, and the DEGs were subjected to Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and gene set enrichment analysis (GSEA). The core genes were screened by GO, KEGG, and GSEA, and the gene-gene interaction (GGI) and protein-protein interaction (PPI) networks of DEGs were constructed. The GeneCards database was used to obtain CAD-related genes, and the GEO dataset was used to obtain intersecting genes. The intersecting genes were analyzed for bioenrichment and prediction of potential therapeutic agents, and predictive models were constructed for the intersecting genes. Finally, immune infiltrating cells from the GEO dataset were analyzed.Results: A total of 79 DEGs were screened in the peripheral blood of CAD patients, of which three were autophagy-related genes. Biological enrichment analysis showed that the DEGs were associated with metabolic pathways, and vascular smooth muscle contraction and were mainly involved the MAPK signaling pathway, metabolic pathways, and the PI3K-Akt signaling pathway. The S100A8, ENTPD1, and MMP9 further screened were screened. A total of 11 CAD crossover genes and 75 potential therapeutic agents were obtained, and the column line graph prediction models constructed for S100A8, HSPB1, F5, MMP9, and PDE9A had good predictive power. There were significant differences in immune cells in CAD patients compared to healthy individuals, especially in T cells regulatory (Tregs) and B cells naïve. Conclusions:The peripheral blood of CAD patients screened by the GEO dataset was significantly different from that of the healthy population, and the DEGs and intersecting genes were involved in numerous key biological processes that may be involved in the development and progression of CAD and could serve as its regulatory sites and therapeutic drug targets.

show abstract

“… 5 , 6 Furthermore, MMP-9 polymorphism, MMP-9/TIMP-1 imbalance and ECM turnover are considered the leading cause of coronary plaque instability and mortality. 8 - 10 …”

Section: Introductionmentioning

confidence: 99%

“…5,6 Furthermore, MMP-9 polymorphism, MMP-9/TIMP-1 imbalance and ECM turnover are considered the leading cause of coronary plaque instability and mortality. [8][9][10] The precise interaction between pro-inflammatory cytokines and MMP-9 is significant in atherosclerotic plaque formation and vascular lesions. 11,12 Several pro-…”

mentioning

confidence: 99%

“…17,18 Moreover, Vitamin D helps in regulating foam cell formation, ECM turnover, expression of MMPs and TIMPs, calcium concentration, and cardiac contractility, which results in a decrease in cardio-hypertrophy. [7][8][9][10][11][12][13][14][15][16][17][18] Vit-D deficiency in heart diseases leads to inflammation and ECM remodeling by activating of inflammatory transcription factors such as NF-κB and AP-1. 19,20 According to recent findings, MMPs and inflammatory factors contribute to the development and progression of cardiovascular diseases.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of MMP-9, IL-6, TNF-α levels and peripheral blood mononuclear cells genes expression of MMP-9 and TIMP-1 in Iranian patients with coronary artery disease

Akbari,

Kazemi Fard,

Fadaei

et al. 2023

J Cardiovasc Thorac Res

View full text Add to dashboard Cite

Introduction: Coronary artery disease (CAD) is the main cause of death and is characterized by atherosclerosis in coronary arteries. Inflammation plays a crucial role in the progression and development of atherosclerosis. Methods: The present study consisted of 132 Iranian individuals who underwent coronary angiography, 65 patients with CAD, and 67 controls. The matrix metalloproteinase-9 (MMP-9), TNF-α, IL-6, and vitamin D serum levels were measured by the ELISA technique. The gene expression of MMP-9 and tissue inhibitors of metalloproteinase (TIMP-1) was estimated by real-time PCR assay. Results: A considerable increase in levels and PBMC gene expression of MMP-9 and serum levels of IL-6 and TNF-α were found in CAD patients compared with controls. A significant decrease was detected in vitamin D levels of CAD patients in comparison with controls. A considerable direct correlation was found between MMP-9 levels and MMP-9 and TIMP1 gene expression in CAD patients. MMP-9 levels positively correlated with LDL-C in CAD patients. The correlation between TIMP1 gene expression and IL-6 levels was also negatively significant. There were positive correlations between MMP-9 levels with IL-6 and TNF-α serum levels in CAD patients. Conclusion: This study showed that the interaction between MMPs, TIMP1, and cytokines could play a role in the pathogenesis of atherosclerosis. The present study suggested that high levels of TNF-α and IL-6 and vitamin D deficiency in our studied patients could disturb the MMP-9/TIMP-1 balance and lipid metabolism, leading to plaque formation/ rupture in predisposed CAD patients.

show abstract

Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population

Cited by 5 publications

References 48 publications

Matrix metallopeptidase-9 prognostic role in STEMI patients after percutaneous coronary intervention (PCI) in one-year follow-up period

Matrix metallopeptidase-9 prognostic role in STEMI patients after percutaneous coronary intervention (PCI) in one-year follow-up period

Differential expression and significance of peripheral blood genes in coronary artery heart disease

Evaluation of MMP-9, IL-6, TNF-α levels and peripheral blood mononuclear cells genes expression of MMP-9 and TIMP-1 in Iranian patients with coronary artery disease

Contact Info

Product

Resources

About