Impact of metabolic control on macular thickness in diabetic macular oedema

Peng, Yajun; Tsai, Meng-Ju

doi:10.1177/1479164117746023

Cited by 16 publications

(13 citation statements)

References 16 publications

(18 reference statements)

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“…The study also confirmed that increasing HbA 1c concentrations above normal are associated with an increasing risk of progression of retinopathy resulting in both PDR and DME [22,[27][28][29][30]. In some recent studies HbA 1c has not been found to be a risk factor for the development of DME [31][32][33] or PDR [34,35]. However, in these studies conclusions were based on single HbA 1c values obtained at the time of examination.…”

Section: Discussionsupporting

confidence: 66%

Systemic risk factors contribute differently to the development of proliferative diabetic retinopathy and clinically significant macular oedema

Bek

2020

Diabetologia

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Aims/hypothesis The purpose of screening for diabetic retinopathy is to detect either of the two sight-threatening complications: proliferative diabetic retinopathy (PDR) or clinically significant diabetic macular oedema (DME). The aim of the study was to evaluate whether systemic risk factors affect the risk of developing these two complications differently. Methods Survival analysis with death as a competing risk was used to describe the effect of sex, age and time of onset of diabetes, systolic (SBP) and diastolic (DBP) BPs, and the weighted exposure and CV of HbA 1c for the development of PDR and DME from all 2773 patients treated for diabetic retinopathy in a defined population from the Aarhus area, Denmark, between 1 July 1994 and 1 July 2019. Results Increasing HbA 1c above normal increased the risk of developing both PDR and DME (p < 0.04), and values below normal increased the risk of developing PDR (p < 0.013). Increasing DBP increased the risk of developing both PDR and DME (p < 0.0001), whereas increasing SBP increased the risk of developing DME (p < 0.0001), but not PDR (p > 0.08). The risk of developing PDR increased with decreasing age of onset of diabetes (p < 0.0001), whereas the risk of developing DME was maximal for a known onset of diabetes at about 30 years of age and decreased significantly for both lower and higher ages of onset (p < 0.0001). The risk of developing both PDR and DME was lower in women than in men (p < 0.004) and was reduced with lower variability of repeated HbA 1c measurements (p < 0.0001). Conclusions/interpretation Systemic risk factors such as metabolic regulation, arterial BP and the age of onset of diabetes contribute differently to the development of PDR and DME. The overall risk of developing treatment-requiring diabetic retinopathy should be calculated from the risks of reaching each of the two complications separately.

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Section: Discussionsupporting

confidence: 66%

Systemic risk factors contribute differently to the development of proliferative diabetic retinopathy and clinically significant macular oedema

Bek

2020

Diabetologia

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“…Similar to our study Yeung L et al 14 also showed that chronic HbA1c levels over the previous year positively correlated with macular thickness and volume in diabetic patients. Peng Yi-Ji et al 15 also found that higher levels of HbA1c were associated with greater CMT and volume in eyes without macular oedema, which was consistent with our study.…”

Section: Discussionsupporting

confidence: 92%

Comparative evaluation of the severity of diabetic macular oedema in patients with and without metabolic syndrome

Jangid¹,

Nainiwal²,

Porwal³

2020

IJCEO

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Diabetic retinopathy may be the most common microvascular complication of diabetes. Retinopathy develops in one of every four diabetics which is major cause of visual impairment. In addition to the micro and macrovascular complications of DM, the potential association between Metabolic syndrome and DR has been also investigated but with inconclusive results Aims & Objective: Comparative evaluation of the severity of diabetic macular oedema in patients with and without metabolic syndrome and the association between Diabetic macular oedema with biochemical parameters (HbA1c, blood sugar, Serum triglycerides, HDL, LDL, VLDL) and Physical parameter (BMI and Waist Circumference). Materials and Methods: Hospital-based prospective observational Study involved 80 patients of diabetic macular oedema carried out over a period of 18 months from January 2018 to June 2019. Based on criteria of metabolic syndrome they were divided into two groups: 1) with metabolic syndrome 2) without metabolic syndrome. Socio demographic profile, macular thickness, biochemical parameters and physical parameters were recorded. Results: Out of 80 patients, 57 (71.2%) were male and 23 (28.8%) were female. Mean age of the patients in metabolic syndrome group was 53.68±4.7 years while mean age of the patients without metabolic syndrome was 56.07±10.14 years. Macular thickness was significantly high in both eyes in subjects with metabolic syndrome compare to without metabolic syndrome. Macular thickness of both eye was found to be positively correlated with HbA1C level (for right eye r = 0.50; for left eye r =0.27) and mean arterial blood pressure eyes (r = 0.41 for right eye & r =0.38 for left eyes). In our study apart from VLDL and HDL no correlation was seen with other individual cholesterol parameters like Total Cholesterol, LDL and triglycerides. Conslusion: In conclusion, Metabolic syndrome and few of its components (BMI, MAP) were significantly associated with an increased risk of macular thickness. However, considering the limitations existed, further studies would be urgently necessary.

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“…Macular thickness is a key landmark in the evaluation and monitoring of different retinal diseases in humans and nonhuman primates [16, 17].…”

Section: Discussionmentioning

confidence: 99%

Macular thickness measurements of healthy, naïve cynomolgus monkeys assessed with spectral-domain optical coherence tomography (SD-OCT)

et al. 2019

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The purpose of this study was to measure central macular thickness in an unprecedented number of cynomolgus monkeys. Macular thickness was measured with Heidelberg spectral-domain OCT in 320 eyes of healthy and treatment-naïve cynomolgus monkeys (80 males and 80 females). The macula was successfully measured in all 320 eyes. Macular thickness was not significantly different between the sexes. The mean central macular thickness was 244 μm (+/- 21 μm). Macular thicknesses in the quadrants were 327 +/-17 μm (temporal inner), 339 +/- 17 μm (inferior inner), 341 +/- 14 μm (superior inner), 341 +/-18 μm (nasal inner), and 299 +/- 20 μm (temporal outer), 320 +/- 16 μm (superior outer), 332 +/-23 μm (inferior outer), and 337 +/-18 μm (nasal outer). Highly significant differences between the nasal and temporal quadrants were detected. This study successfully demonstrated the feasibility of retinal thickness measurements in healthy cynomolgus monkeys. The present findings indicate that the macula is thicker in cynomolgus monkeys than in humans and provide important normative data for future studies.

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Impact of metabolic control on macular thickness in diabetic macular oedema

Cited by 16 publications

References 16 publications

Systemic risk factors contribute differently to the development of proliferative diabetic retinopathy and clinically significant macular oedema

Systemic risk factors contribute differently to the development of proliferative diabetic retinopathy and clinically significant macular oedema

Comparative evaluation of the severity of diabetic macular oedema in patients with and without metabolic syndrome

Macular thickness measurements of healthy, naïve cynomolgus monkeys assessed with spectral-domain optical coherence tomography (SD-OCT)

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