Impact of menopause and diabetes on atherogenic lipid profile: is it worth to analyse lipoprotein subfractions to assess cardiovascular risk in women?

Fonseca, Miriam M.; Silva, Isis Tande da; Ferreira, Sandra Roberta Gouvêa

doi:10.1186/s13098-017-0221-5

Cited by 51 publications

(36 citation statements)

References 177 publications

(169 reference statements)

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“…The serum TG and HDL-C levels improved in both sexes with increasing BWR and in the group with a %BWC < -3% to -5% only in men. In women, serum lipid levels change with age; TG levels rapidly increase after the age of about 50 years in women due to menopause 22 and this may complicate the serum lipid change by BWR in women.…”

Section: Weight Reduction and Metabolic Parametersmentioning

confidence: 99%

Body Weight Reduction of 5% Improved Blood Pressure and Lipid Profiles in Obese Men and Blood Glucose in Obese Women: A Four-Year Follow-up Observational Study

Hasegawa

Nakagami

Oya

et al. 2019

Metabolic Syndrome and Related Disorders

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Background: Body weight reduction (BWR) of at least 3% in obese Japanese individuals through lifestyle interventions has improved the risk factors for cardiovascular disease (CVD). We aimed to assess the relation between body weight change (BWC) and CVD risk change and to identify lifestyle improvement related to BWR in obese Japanese individuals. Methods: Subjects were 2579 health checkup examinees without medicated diabetes, hypertension or dyslipidemia, and a body mass index ‡25 kg/m 2 who completed lifestyle questionnaires in 2008 and 2012. The 4year changes in fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), lipids, and blood pressure (BP) levels were compared across the five groups based on the 4-year BWC, and presented as <-5%,-5% to-3%,-3% to-1%,-1% to 1%, and ‡1%. Multivariable logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CI) for lifestyle improvement related to BWR. Results: Comparing the groups to the reference group (BWC ranging from-1% to +1%), we observed that FPG and HbA1c levels were lower in women in the <-5% group; BP levels were also lower in the <-5% group; triglyceride levels had improved in the <-3% group, and low-density lipoprotein cholesterol levels in the <-5% group; high-density lipoprotein cholesterol levels had improved in men in the <-5% group. In men, the adjusted OR (95% CI) for BWR related to lifestyle improvement pertaining to ''over 30 min exercise'' was 2.6 (2.0-3.6). In women, the adjusted ORs for BWR related to ''walking or physical activity,'' ''drinking alcohol,'' and ''drinking more than a glass of sake'' were 1.7 (1.1-2.7), 1.9 (1.1-3.5), and 1.8 (1.1-3.0), respectively. Conclusions: A 5% BWR improved FPG and HbA1c levels in obese women, and BP and lipid levels in obese men. Improvements in exercise and alcohol consumption habits were associated with BWR in this population.

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Section: Weight Reduction and Metabolic Parametersmentioning

confidence: 99%

Body Weight Reduction of 5% Improved Blood Pressure and Lipid Profiles in Obese Men and Blood Glucose in Obese Women: A Four-Year Follow-up Observational Study

Hasegawa

Nakagami

Oya

et al. 2019

Metabolic Syndrome and Related Disorders

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“…The direct impact of insulin resistance on lipid metabolism in type 2 diabetes DMT2 is quite well-known, while in DM type 1 the mechanisms related to insulin deficiency and dyslipidaemia remain poorly understood and controversial. According to studies, diabetes generally promotes not only quantitative changes in the amount of circulating lipids – particularly an increase in triglycerides and LDL as well as a reduction in HDL but also qualitative and kinetic in nature [ 59 – 61 ]. Decreased plasma concentration, triacylglycerol enrichment, reduced phospholipids, ApoE and ApoM, glycation and increased HDL catabolism are the main changes occurring in diabetes [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

The role and function of HDL in patients with diabetes mellitus and the related cardiovascular risk

Gluba-Brzózka²,

et al. 2017

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BackgroundDiabetes mellitus (DM) is a major public health problem which prevalence is constantly raising, particularly in low- and middle-income countries. Both diabetes mellitus types (DMT1 and DMT2) are associated with high risk of developing chronic complications, such as retinopathy, nephropathy, neuropathy, endothelial dysfunction, and atherosclerosis.MethodsThis is a review of available articles concerning HDL subfractions profile in diabetes mellitus and the related cardiovascular risk. In this review, HDL dysfunction in diabetes, the impact of HDL alterations on the risk diabetes development as well as the association between disturbed HDL particle in DM and cardiovascular risk is discussed.ResultsChanges in the amount of circulation lipids, including triglycerides and LDL cholesterol as well as the HDL are frequent also in the course of DMT1 and DMT2. In normal state HDL exerts various antiatherogenic properties, including reverse cholesterol transport, antioxidative and anti-inflammatory capacities. However, it has been suggested that in pathological state HDL becomes “dysfunctional” which means that relative composition of lipids and proteins in HDL, as well as enzymatic activities associated to HDL, such as paraoxonase 1 (PON1) and lipoprotein-associated phospholipase 11 (Lp-PLA2) are altered. HDL properties are compromised in patients with diabetes mellitus (DM), due to oxidative modification and glycation of the HDL protein as well as the transformation of the HDL proteome into a proinflammatory protein. Numerous studies confirm that the ability of HDL to suppress inflammatory signals is significantly reduced in this group of patients. However, the exact underlying mechanisms remains to be unravelled in vivo.ConclusionsThe understanding of pathological mechanisms underlying HDL dysfunction may enable the development of therapies targeted at specific subpopulations and focusing at the diminishing of cardiovascular risk.

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“…For specific characteristics, ageing or postmenopause mechanistically predisposes individuals to decreased NO bioavailability, increased oxidative stress, inflammation, and atherogenic lipid profiles, contributing to an increased risk of developing CVD [ 42 , 43 ]. Increasing evidence has also shown that the adverse events of NO bioavailability, oxidative stress, and inflammation similarly exist in diabetes mellitus, hypercholesterolaemia, hypertension, and chronic kidney disease [ 44 – 47 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Impaired Vascular Endothelial Function with Increased Cardiovascular Risk in Asymptomatic Adults

Zhong

Nong

Mao

et al. 2018

BioMed Research International

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Impaired vascular endothelial function has attracted attention as a prognostic indicator of cardiovascular prevention. The association between impaired endothelial function and cardiovascular risk in the asymptomatic population, however, has been poorly explored. We evaluated the association of brachial artery flow-mediated dilation (FMD) with Framingham-estimated 10-year cardiovascular disease (CVD) risk in subjects free of CVD, especially by cardiovascular risk profiles. In total, 680 adults aged 30-74 years were enrolled from Rongan and Rongshui of Liuzhou, Guangxi, China, through a cross-sectional study in 2015. In the full-adjusted model, the odds ratio for the estimated 10-year CVD risk comparing the low FMD (<6%) with the high FMD (≥10%) was 2.81 (95% confidence interval [CI]: 1.21, 6.53; P for trend = 0.03). In subgroup analyses, inverse associations between FMD and the estimated 10-year CVD risk were found in participants with specific characteristics. The adjusted odds ratios, comparing the 25th and the 75th percentiles of FMD, were 2.77 (95% CI: 1.54, 5.00) for aged ≥60 years, 1.77 (95% CI: 1.16, 2.70) for female, 1.59 (95% CI: 1.08, 2.35) for nonsmokers, 1.74 (95% CI: 1.02, 2.97) for hypertension, 1.59 (95% CI: 1.04, 2.44) for normal glycaemia, 2.03 (95% CI: 1.19, 3.48) for C-reactive protein ≥10 mg/L, and 1.85 (95% CI: 1.12, 3.06) for eGFR <106 mL/minute per 1.73 m2. Therefore, impaired endothelial function is associated with increased CVD risk in asymptomatic adults. This inverse association is more likely to exist in subjects with higher cardiovascular risk.

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Impact of menopause and diabetes on atherogenic lipid profile: is it worth to analyse lipoprotein subfractions to assess cardiovascular risk in women?

Cited by 51 publications

References 177 publications

Body Weight Reduction of 5% Improved Blood Pressure and Lipid Profiles in Obese Men and Blood Glucose in Obese Women: A Four-Year Follow-up Observational Study

Body Weight Reduction of 5% Improved Blood Pressure and Lipid Profiles in Obese Men and Blood Glucose in Obese Women: A Four-Year Follow-up Observational Study

The role and function of HDL in patients with diabetes mellitus and the related cardiovascular risk

Association of Impaired Vascular Endothelial Function with Increased Cardiovascular Risk in Asymptomatic Adults

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