Impact of measures to control brucellosis on disease characteristics in humans: experience from an endemic region in the Balkans

Bosilkovski, Mile; Stojanov, Aleksandar; Stevanović, Milena; Karadzovski, Zarko; Krstevski, Kiril

doi:10.1080/23744235.2017.1407037

Cited by 12 publications

(12 citation statements)

References 27 publications

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“…Veterinarians and veterinary assistants showed to be largely exposed to Brucella spp., totalizing 189 individuals with positive diagnostic of brucellosis. Those infections, probably related to PLOS NEGLECTED TROPICAL DISEASES their occupational activities, were reported by fifteen articles [2,19,23,24,28,31,35,43,[50][51][52][53][54][55][56], mostly from Asia (n = 121), Europe (n = 40), and Americas (n = 27) and the minority from Africa (n = 1). Manipulation of live attenuated anti-brucellosis vaccines, described in seven studies, was the most reported exposure source (Table 3).…”

Section: Veterinarians and Veterinary Assistantsmentioning

confidence: 99%

Occupational exposure to Brucella spp.: A systematic review and meta-analysis

et al. 2020

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Brucellosis is a neglected zoonotic disease of remarkable importance worldwide. The focus of this systematic review was to investigate occupational brucellosis and to identify the main infection risks for each group exposed to the pathogen. Seven databases were used to identify papers related to occupational brucellosis: CABI, Cochrane, Pubmed, Scielo, Science Direct, Scopus and Web of Science. The search resulted in 6123 studies, of which 63 were selected using the quality assessment tools guided from National Institutes of Health (NIH) and Case Report Guidelines (CARE). Five different job-related groups were considered greatly exposed to the disease: rural workers, abattoir workers, veterinarians and veterinary assistants, laboratory workers and hunters. The main risk factors and exposure sources involved in the occupational infection observed from the analysis of the articles were direct contact with animal fluids, failure to comply with the use of personal protective equipment, accidental exposure to live attenuated anti-brucellosis vaccines and non-compliance with biosafety standards. Brucella species frequently isolated from job-related infection were Brucella melitensis, Brucella abortus, Brucella suis and Brucella canis. In addition, a metaanalysis was performed using the case-control studies and demonstrated that animal breeders, laboratory workers and abattoir workers have 3.47 [95% confidence interval (CI); 1.47-8.19] times more chance to become infected with Brucella spp. than others individuals that have no contact with the possible sources of infection. This systematic review improved the understanding of the epidemiology of brucellosis as an occupational disease. Rural workers, abattoir workers, veterinarians, laboratory workers and hunters were the groups more exposed to occupational Brucella spp. infection. Moreover, it was observed that the lack of knowledge about brucellosis among frequently exposed professionals, in addition to some behaviors, such as negligence in the use of individual and collective protective measures, increases the probability of infection.

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Section: Veterinarians and Veterinary Assistantsmentioning

confidence: 99%

Occupational exposure to Brucella spp.: A systematic review and meta-analysis

et al. 2020

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“…The treatment that was administrated in our patient did not differ from the therapeutic approach used in patients with uncomplicated brucellosis in this region [2]. The treatment resulted with successful response rendering the thyroiditis in a shorter period than seen in several other studies [3,7,9,10].…”

Section: Discussionmentioning

confidence: 62%

“…It is one of the most widespread zoonoses worldwide. Brucellosis has high morbidity, both for humans and animals; It is an important cause of economic loss and a public health problem in many developing countries [2].…”

Section: Acute Thyroiditis Associated With Brucellosis: a Case Reportmentioning

confidence: 99%

Acute Thyroiditis Associated with Brucellosis: A Case Report

Cvetkova

Bitoska

Poposki

et al. 2019

Prilozi

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Brucella thyroiditis represents an extremely rare focal form of brucellosis. In this case report we describe a 55 years old male, diagnosed with brucellosis and peripheral arthritis with subsequent development of acute thyroiditis. The symptoms duration consistent with brucellosis started two weeks before establishing the diagnosis. Only a day after diagnosis and initiation of antibrucellar treatment, acute non-suppurative thyroiditis suddenly manifested. Thyroiditis was diagnosed with clinical inspection and confirmed by ultrasound investigation. With the appropriate antibrucellar treatment, complete cure of thyroid affection was reached in ten days and the patient remained well during the follow-up period of two and a half years. In conclusion, in brucellosis endemic regions brucellosis should be included in the diagnostic consideration in patients with acute non-suppurative thyroiditis. Early recognition and adequate treatment of brucella thyroiditis results in favorable outcome.

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“…Most people infected with brucellosis have an apparent history of exposure, such as exposure to infected animals, ingestion of brucella contaminated animal products, and inhalation of brucella containing aerosols. Brucellosis is able to cause various symptoms involving multiple systems [ 4 ] and easy to be misdiagnosed due to lack of specificity. Here, we report a male 5-year-and-11-month old Chinese child, who was diagnosed brucellosis with meningoencephalitis, coronary aneurysm and keratitis, which has not been reported before.…”

Section: Introductionmentioning

confidence: 99%

Meningoencephalitis, coronary artery and keratitis as an onset of brucellosis: a case report

Geng

Feng

et al. 2020

BMC Infect Dis

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Background Brucellosis is a zoonotic disease caused by brucella. It has been an increasing trend in recent years (Wang H, Xu WM, Zhu KJ, Zhu SJ, Zhang HF, Wang J, Yang Y, Shao FY, Jiang NM, Tao ZY, Jin HY, Tang Y, Huo LL, Dong F, Li ZJ, Ding H, Liu ZG, Emerg Microbes Infect 9:889-99, 2020). Brucellosis is capable to invade multiple systems throughout the body, lacking in typical clinical manifestations, and easily misdiagnosed and mistreated. Case presentation We report a case of a male, 5-year-and-11-month old child without relevant medical history, who was admitted to hospital for 20 days of fever. When admitted to the hospital, we found that he was enervated, irritable and sleepy, accompanied with red eyes phenomenon. After anti-infection treatment with meropenem, no improvement observed. Lumbar puncture revealed normal CSF protein, normal cells, and negative culture. Later, doppler echocardiography suggested coronary aneurysms, and incomplete Kawasaki Disease with coronary aneurysms was proposed. The next day, brucellosis agglutination test was positive. Metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid suggested B.melitensis, which was confirmed again by blood culture. The child was finally diagnosed as brucellosis with meningocephalitis, coronary aneurysm and keratitis. According to our preliminary research and review, such case has never been reported in detail before. After diagnosis confirmation, the child was treated with rifampicin, compound sulfamethoxazole, and ceftriaxone for cocktail anti-infection therapy. Aspirin and dipyridamole were also applied for anticoagulant therapy. After medical treatment, body temperature of the child has reached normal level, eye symptoms alleviated, and mental condition gradually turned normal. Re-examination of the doppler echocardiographic indicated that the coronary aneurysm was aggravated, so warfarin was added for amplification of anticoagulation treatment. At present, 3 months of follow-up, the coronary artery dilatation gradually assuaged, and the condition is continued to alleviate. Conclusion Brucellosis can invade nervous system, coronary artery, and cornea. Brucellosis lacks specific signs for clinical diagnosis. The traditional agglutination test and the new mNGS are convenient and effective, which can provide the reference for clinical diagnosis.

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Impact of measures to control brucellosis on disease characteristics in humans: experience from an endemic region in the Balkans

Abstract: The national strategy for brucellosis control, which included vaccination of small ruminants, resulted in a decrease of human brucellosis cases in the Republic of Macedonia and there was a tendency to milder disease manifestations.

Cited by 12 publications

References 27 publications

Occupational exposure to Brucella spp.: A systematic review and meta-analysis

Occupational exposure to Brucella spp.: A systematic review and meta-analysis

Acute Thyroiditis Associated with Brucellosis: A Case Report

Meningoencephalitis, coronary artery and keratitis as an onset of brucellosis: a case report

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