Impact of matrine on inflammation related factors in rat intestinal microvascular endothelial cells

Suo, Zhan-Wei; Liu, Ye; Ferreri, Miro; Zhang, Tao; Liu, Zhongjie; Xiang, Ming; Han, Bo

doi:10.1016/j.jep.2009.07.023

Cited by 35 publications

(14 citation statements)

References 34 publications

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“…Matrine has been used widely in China for the treatment of viral [23], hepatitis [24], hepatic fibrosis [25], arrhythmia [26] and skin diseases [27]. In recent years, increasing studies showed Matrine also exhibits antitumor effects by inhibiting proliferation and inducing cell cycle arrest and apoptosis in different cancer cells, including leukemia, gastric cancer, hepatocellular carcinoma, breast cancer and lung cancer.…”

Section: Introductionmentioning

confidence: 99%

Matrine Activates PTEN to Induce Growth Inhibition and Apoptosis in V600EBRAF Harboring Melanoma Cells

Jin

Sun

Wang

et al. 2013

IJMS

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Here, we report a natural chemical Matrine, which exhibits anti-melanoma potential with its PTEN activation mechanism. Matrine effectively inhibited proliferation of several carcinoma cell lines, including melanoma V600EBRAF harboring M21 cells. Flow cytometry analysis showed Matrine induced G0/G1 cell cycle arrest in M21 cells dose-dependently. Apoptosis in M21 cells induced by Matrine was identified by Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) analysis and Annexin-V/FITC staining. Molecular mechanistic study suggested that Matrine upregulated both mRNA level and protein expression level of phosphatase and tensin homolog deleted on chromosome ten (PTEN), leading to inhibition of the PI3K/Akt pathway. Downregulation of phosphor-Aktser473 by Matrine activated p21 and Bax, which contributed to G0/G1 cell cycle and apoptosis. Besides, Matrine enhanced the PI3K/Akt inhibition effects to inhibit the cell proliferation with PI3K inhibitor, LY2940002. In summary, our findings suggest Matrine is a promising antitumor drug candidate with its possible PTEN activation mechanisms for treating cancer diseases, such as melanomas.

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Section: Introductionmentioning

confidence: 99%

Matrine Activates PTEN to Induce Growth Inhibition and Apoptosis in V600EBRAF Harboring Melanoma Cells

Jin

Sun

Wang

et al. 2013

IJMS

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“…It shows pharmacological effects in the treatment of several diseases including inflammations like enteritis, hepatitis and atopic dermatitis [2] and cardiovascular diseases, like hypertension, ischemia, angiosclerosis and septic shock [3]. Matrine also plays an important role in the treatment of antifebrile, ache, diuretic, tussis, antidote, tumor [4] and skin diseases [1].…”

Section: Introductionmentioning

confidence: 99%

“…Then from the slope of the i pa Àv 1/2 relation, the electrode surface areas of the modified GCE and bare GCE were calculated to be 5.89 mm 2 and 5.69 mm 2 , respectively. The results showed that the effective area of the modified electrode increased.…”

mentioning

confidence: 99%

Determination of Matrine Using a New Voltammetric Sensor Based on L‐Cysteine/Graphene Oxide‐Chitosan Composite Film Modified Electrode

et al. 2012

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A new voltammetric sensor for matrine was fabricated via the polymerization of l-cysteine on graphene oxide, which served as templates. The fabricated electrode can improve the oxidation of matrine intensively, and enable the determination of matrine in the range from 4 10 À6 to 1 10 À4 mol L À1 , with a detection limit of 2 10 À6 mol L À1. The oxidation process of matrine was studied and some dynamic parameters were calculated using various electrochemical techniques. This present sensor displayed good stability, reproducibility and sensitivity for matrine. It was successfully applied to the quantitative determination of matrine in matrine injection with satisfactory results.

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“…11,12 Matrine inhibited the activity of peritoneal macrophages to produce fi brogenic cytokines induced by lipopolysaccharide (LPS), 13 and also reduced LPS-induced damage to rat intestinal microvascular endothelial cells by reducing the production of interleukin (IL)-6, IL-8, and soluble intercellular adhesion molecule-1 (sICAM-1). 14 Matrine also exhibited a potential protective effect against 17α-ethinyl estradiolinduced acute liver cholestasis in rats, 15 and attenuated acetaminophen-induced hepatotoxicity and reduced the number and area of γ-glutamyltranspeptidase-positive foci by its anti-infl ammatory effect, when combined with glycyrrhizin. 16 It also decreased the total bilirubin and improved survival in liver transplantation patients when combined with Kushen, a traditional Chinese medicinal herb.…”

Section: Introductionmentioning

confidence: 96%

Matrine attenuates endotoxin-induced acute liver injury after hepatic ischemia/reperfusion in rats

et al. 2011

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Impact of matrine on inflammation related factors in rat intestinal microvascular endothelial cells

Cited by 35 publications

References 34 publications

Matrine Activates PTEN to Induce Growth Inhibition and Apoptosis in V600EBRAF Harboring Melanoma Cells

Matrine Activates PTEN to Induce Growth Inhibition and Apoptosis in V600EBRAF Harboring Melanoma Cells

Determination of Matrine Using a New Voltammetric Sensor Based on L‐Cysteine/Graphene Oxide‐Chitosan Composite Film Modified Electrode

Matrine attenuates endotoxin-induced acute liver injury after hepatic ischemia/reperfusion in rats

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