Impact of material properties and process variables on the residence time distribution in twin screw feeding equipment

Snick, B. Van; Kumar, Ashish; Verstraeten, Maxim; Pandelaere, K.; Dhondt, Jens; Pretoro, G. Di; Beer, Thomas De; Vervaet, Chris

doi:10.1016/j.ijpharm.2018.11.076

Cited by 41 publications

(16 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent publication has shown, that the RTD in twin-screw feeders can reach extensive time spans, especially for low feed rates, as typically used in process development, i.e. also in this study (Van Snick et al, 2018). Washout period for a K-Tron KT20 feeder in their study lasted over three hours with feed rate 10 kg/h.…”

Section: General Approachesmentioning

confidence: 84%

Measurement of residence time distributions and material tracking on three continuous manufacturing lines

Karttunen

Hörmann

Leersnyder

et al. 2019

International Journal of Pharmaceutics

View full text Add to dashboard Cite

Over the recent decade, benefits of continuous manufacturing (CM) of pharmaceutical products have been acknowledged widely. In contrast to batch processes, the product is not physically separated into batches in CM, which creates a few challenges. Product release is done for batches that should have a uniform quality over time, materials need to be tracked along the line, and locations to reject product must be established. To enable these, the residence time distributions (RTDs) of all unit operations must be known. In this paper, three CM tableting lines, each employing a different granulation technique, were investigated. The RTDs of their main unit operations were characterized, utilizing different measurement techniques successfully. All of these RTD measurement techniques could have been performed in any of the lines. The differences were related to the techniques themselves. Overall, external tracer with in-line Near-Infrared detection or color tracer with video recording proved most usable techniques, with few limitations. The RTDs for full lines were calculated by convoluting the unit operation RTDs, which enables material tracking through entire lines. The lines exhibited both truly continuous and quasi-continuous unit operations. Quasi-continuous unit operations divide the material stream into lots that can be utilized for tracking and rejection.

show abstract

Section: General Approachesmentioning

confidence: 84%

Measurement of residence time distributions and material tracking on three continuous manufacturing lines

Karttunen

Hörmann

Leersnyder

et al. 2019

International Journal of Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…With this dataset it is possible to obtain residence time distributions (RTDs) to characterize the discharge process.The residence time data in this dataset can be used to model material tracking in a continuous pharmaceutical production process through RTD modeling [1]. Obtaining the same or similar data with experiments is difficult: Experimental determination of RTDs in feeders is material intensive and requires one experiment for each examined fill level [2]. The data can be used to find an optimal fill level and refill strategy, and designing an experiment for confirmation.Starting positions of particles inside the feeder are included in the dataset, which allows the definition and analysis of arbitrary spatial sub-regions of the feeder.…”

mentioning

confidence: 99%

“…Obtaining the same or similar data with experiments is difficult: Experimental determination of RTDs in feeders is material intensive and requires one experiment for each examined fill level [2]. The data can be used to find an optimal fill level and refill strategy, and designing an experiment for confirmation.…”

mentioning

confidence: 99%

Particle-level residence time data in a twin-screw feeder

Toson

Khinast

2019

Data in Brief

View full text Add to dashboard Cite

A full discharge process of a twin-screw feeder has been simulated with DEM (discrete element method). The result files are available at the Mendeley Data repository (https://doi.org/10.17632/d76rzzd8r7.1) and contain the following particle data: x,y,z coordinates of the initial position inside the feeder, particle radius, and the discharge time of each particle are available at three different initial feeder fill levels. With this data it is possible to generate residence time distributions (RTDs) of arbitrary spatial regions in the feeder to analyze the material flow inside the feeder, optimize refill strategies, and ultimately improve batch definition in continuous manufacturing. Example RTDs and evaluation scripts are available in the repository.

show abstract

“…As suggested by Escotet-Espinoza et al ρ e (t) = ρ 0 + κ ln σ v (t) 1000 (14) where ρ 0 describes the eective density under no vertical stress, σ v is the vertical stress expressed in kPa. Both ρ 0 and κ are found by tting the model to experimental data.…”

Section: Time-dependant Powder Densitymentioning

confidence: 99%

Hybrid Mechanistic-Empirical Approach to the Modeling of Twin Screw Feeders for Continuous Tablet Manufacturing

Bascone

Galvanin

Shah

et al. 2020

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

Nowadays, screw feeders are popular equipment in the pharmaceutical industry.However, despite the increasing research in the last decade in the manufacturing of powder-based products, there is still a lack of knowledge on the physics governing the dynamic behaviour of these systems. As a result, data-driven models have often been used to address process design, optimisation and control applications.In this paper, a methodology for the modelling of twin screw feeders has been suggested. A rst order plus dead time model has been developed where a hybrid mechanistic-empirical approach has been used. Dierent powders and two screw feeder geometries have been investigated. The model predictions are in good agreement with the experimental measurements when the 35-mm diameter screws are employed. When the 20 mm-diameter screws are used, the validity range of the model is limited for the least cohesive powders, suggesting that their screw speed-dependant resistance to ow in small screws requires further investigations.

show abstract

Impact of material properties and process variables on the residence time distribution in twin screw feeding equipment

Cited by 41 publications

References 20 publications

Measurement of residence time distributions and material tracking on three continuous manufacturing lines

Measurement of residence time distributions and material tracking on three continuous manufacturing lines

Particle-level residence time data in a twin-screw feeder

Hybrid Mechanistic-Empirical Approach to the Modeling of Twin Screw Feeders for Continuous Tablet Manufacturing

Contact Info

Product

Resources

About