Impact of marital status on renal cancer patient survival

Abstract

Marital status is an independent prognostic factor for various cancer types. The present study used the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute (NCI) to analyze the impact of marital status on renal cancer patient survival outcomes. We identified a total of 62,405 eligible patients (23,800 women and 38,605 men). Overall 5-year renal cancer cause-specific survival (CSS) was 80.3% in the married group, 69.2% in the widowed group, 78.9% in the single group, and 76.5% in the divorced/separated group. The widowed patient group had the highest female/male ratio, more distant metastases, and fewer high-grade (III/IV) tumors. Most widowed patients (90.4%) were elderly (>60 years old). In our study, male renal cancer patients benefited more from marriage than females. We also found that white married patients had better survival outcomes than other white patient groups, but black unmarried and married patients exhibited similar survival outcomes. Our results show that, in general, unmarried patients have higher rates of cancer-specific mortality and highlight the importance of psychological intervention for cancer patients during treatment.

Effect of marital status on survival in glioblastoma multiforme by demographics, education, economic factors, and insurance status

“…Similar results were observed in patients with renal cancer 34. Prior studies have indicated that the social and mental support provided by marriage is different across different races.…”

Marital status and survival in patients with renal cell carcinoma

“…Herein, we used SEER data to elucidate whether insurance status, in addition to ethnicity, age, and SEER stage, among other factors, may play an important role in the survival disparity. Besides, in Wang et al's report, [ 14 ] a total of 62,405 eligible patients diagnosed between 2004 and 2013 were enrolled; however, in our study, an even bigger sample of 97,662 eligible patients diagnosed between 1973 and 2013 were included. Additionally, in Miao et al's report, [ 15 ] the kidney cancer patients included both renal cancer and renal pelvis cancer patients; the pathology of these 2 types of cancer is completely different.…”

“…Actually, we made a further analysis to seek out possible explanations for the survival difference. In both previous studies, [ 14 , 15 ] insurance status was not included as a covariate, and the effect of insurance on the survival outcome of patients with renal cancer was not considered. Herein, we used SEER data to elucidate whether insurance status, in addition to ethnicity, age, and SEER stage, among other factors, may play an important role in the survival disparity.…”

“…Meanwhile, social network and social economic factors have significantly changed in the United States in the past decades. Two previous studies have implicated that marriage status might influence the survival of RCC, [ 14 , 15 ] however, the results remain inconclusive. Therefore, in the present study, we used the Surveillance, Epidemiology, and End Results (SEER) database to explore the impact of marital status on survival outcomes of renal cancer patients.…”

A real-world 1:1 propensity-matched study revealed unmarried status was independently associated with worse survival for patients with renal clear cell carcinoma

“…It is postulated that married status could contribute to optimistic psychological, enough social support, decent incomes, healthy lifestyle and comfortable living conditions. Similarly, previous studies reported that that marital status was a prognostic factor of survival in kidney cancer patients9-11. However, all of them merely focus on all kinds of kidney cancer without differentiating pathological subtypes.…”