Impact of low and high molecular weight oat beta-glucan on oxidative stress and antioxidant defense in spleen of rats with LPS induced enteritis

Hepato- and gastro- protective activity of purified oat 1–3, 1–4-β- d -glucans of different molecular weight

“…Diet which was also confirmed in the study on humans blood plasma [34]. In our study we did not observe significant increase of this oxysterol in liver tissue caused by LPS, but as reported earlier we observed significant increase of this parameter caused by LPS injections in plasma and spleen of animals what can suggest different responses of those organs to ongoing inflammation [21,22]. Supplementation of diet with both high and low molecular weight beta-glucan caused, on the other hand, significant decrease of 25-dihydroxycholesterol concentration in the tissue of liver comparing to healthy and LPS-treated rats fed control diet.…”

“…These actions of beta glucan lead to amelioration of inflammatory response and milder increase in SOD and GPx activity. As described previously, similar results were observed in the blood, spleen and colon of rat fed G1 diet and in the blood and colon of rats fed G2 diet [20,21,22]. Overall these results suggest that high molecular weight beta-glucan is more potent in ameliorating of gastrointestinal inflammation, which is in line in the results of other studies investigating the effect of beta-glucans molecular weight on its antioxidant activity [9].…”

“…LPS-induced enteritis model, used in this study, reflects systemic inflammation which leads to an increase of lipid peroxidation in tissues like blood and spleen [20,21,22]. It can be expected that LPS-induced enteritis in rats, will also cause increase of lipid peroxidation products concentration in the tissues of stomach and possibly liver.…”

The Mutual Correlation of Glucose, Starch, and Beta-Glucan Release During Microwave Heating and Antioxidant Activity of Oat Water Extracts

“…As the gastrointestinal tract is one of the main entrances for possible harmful substances entering a human system, therefore, its homeostasis is the second fundamental purpose of eating beyond nutrition. Several lastly published research has highlighted bioactivity of oat beta-glucan which exceeds only the mechanistic role of the viscous film, formed in the gastrointestinal tract, and revealed strong metabolic influence on intestine, stomach, and spleen, as well as hepatoprotective activity (Błaszczyk et al 2015;Suchecka et al 2016). The extremely interesting from the bioactivity point of view is an antioxidant activity of oat fractions in vitro (Sang and Chu 2017) and especially the betaglucan in vivo (Suchecka et al 2015) which action mechanism is still not clear and being associated both with residual phenolic content (Wang et al 2017) and activity of multiple anomeric hydrogen atoms of carbohydrate polymers (Shah et al 2017).…”

“…Several lastly published research has highlighted bioactivity of oat beta-glucan which exceeds only the mechanistic role of the viscous film, formed in the gastrointestinal tract, and revealed strong metabolic influence on intestine, stomach, and spleen, as well as hepatoprotective activity (Błaszczyk et al 2015;Suchecka et al 2016). The extremely interesting from the bioactivity point of view is an antioxidant activity of oat fractions in vitro (Sang and Chu 2017) and especially the betaglucan in vivo (Suchecka et al 2015) which action mechanism is still not clear and being associated both with residual phenolic content (Wang et al 2017) and activity of multiple anomeric hydrogen atoms of carbohydrate polymers (Shah et al 2017). The antioxidant activity of oat fractions, confirmed both in vitro and in vivo (Masisi et al 2016), turns them into a valuable resource of antioxidants which can impact the total antioxidant activity of human plasma (Harasym and Oledzki 2014).…”