Hepato- and gastro- protective activity of purified oat 1–3, 1–4-β- d -glucans of different molecular weight

Chemopreventive Effect of the Germinated Oat and Its Phenolic-AVA Extract in Azoxymethane/Dextran Sulfate Sodium (AOM/DSS) Model of Colon Carcinogenesis in Mice

“…In the liver, AVA treatment normalized GST and NQO1 activities, while SO induced both activities. These results suggest that SO is more efficient in activating the Keap1-Nrf2 signaling pathway compared to treatment with AVA, which confirms that oat phenolic compounds together with β-glucans may be acting synergistically, thus offering greater protection for cancer prevention and treatment [65,83]. Tissue differences in GST activity might be attributed to cis elements in the promoter regions of these genes, known as the antioxidant/electrophile response elements, and the presence of the various transcription factors (members of the mammalian cap'n'collar (CNC) transcription factor family that possess a well-conserved basic region-leucine zipper (bZIP) motif) that heterodimerize with Nrf2, thus resulting in higher basal and inducible activities of GST in the liver as those compared to other tissues [74,84].…”

“…Studies regarding the chemopreventive effect of oat sprouts and whole oats are limited in comparison with those discussing the unique polyphenolic alkaloids-AVAs-exclusively extracted from oats, among other compounds such as steroidal saponins, β-glucan, and flavonoids [5,[9][10][11]13,15,44,45,52,[65][66][67][68], mainly through mechanisms related to their antioxidant, anti-inflammatory, immunomodulatory, antiproliferative, proapoptotic, cancer cell growth, and senescence control activities. These studies suggest that the notion of effective antitumor activity arising from whole oats may be due to the synergistic effects of multiple compounds rather than any one nutrient or compound alone.…”

The Mutual Correlation of Glucose, Starch, and Beta-Glucan Release During Microwave Heating and Antioxidant Activity of Oat Water Extracts

“…As the gastrointestinal tract is one of the main entrances for possible harmful substances entering a human system, therefore, its homeostasis is the second fundamental purpose of eating beyond nutrition. Several lastly published research has highlighted bioactivity of oat beta-glucan which exceeds only the mechanistic role of the viscous film, formed in the gastrointestinal tract, and revealed strong metabolic influence on intestine, stomach, and spleen, as well as hepatoprotective activity (Błaszczyk et al 2015;Suchecka et al 2016). The extremely interesting from the bioactivity point of view is an antioxidant activity of oat fractions in vitro (Sang and Chu 2017) and especially the betaglucan in vivo (Suchecka et al 2015) which action mechanism is still not clear and being associated both with residual phenolic content (Wang et al 2017) and activity of multiple anomeric hydrogen atoms of carbohydrate polymers (Shah et al 2017).…”

Beta‐glucan from Agrobacterium sp. ZX09 improves growth performance and intestinal function in weaned piglets

“…Current report strongly demonstrates that optimal dosage of beta‐glucan derived from Agrobacterium sp. ZX09 was 100 mg per kg of diet for weaned piglets, while the optimal dose of other tested beta‐glucans were variant, and their sources were mainly obtained from cell wall of Saccha‐romycetes cerevisiae (Shao, Wang, Tian, Guo, & Zhang, ; Tian et al, ) and substantially purified from oat (Suchecka et al, ; Suchecka, Harasym, Wilczak, & Gromadzka‐Ostrowska, ). Beta‐glucan content obtained from Agrobacterium sp.…”