Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic Retinopathy

Chen, Chuang; Yang, Yi‐Sun; Kornelius, Edy; Huang, Chien‐Ning; Hsu, Min‐Yen; Lee, Chia-Yi; Yang, Shun‐Fa

doi:10.3389/fgene.2022.889530

Cited by 5 publications

(1 citation statement)

References 48 publications

(57 reference statements)

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“…There are some factors that affect the development and progression of DR. A higher glycated hemoglobin (HbA1c) level, a longer duration of diabetes mellitus, hypertension, and dyslipidemia are associated with diabetic retinopathy (Cheung et al, 2010;Lin et al, 2021). Moreover, genetic factors play an essential role in DR, and genetic studies show a racial variation in DR's incidence (Simó-Servat et al, 2013;Cho and Sobrin, 2014;Mankoč Ramuš et al, 2021;Chuang et al, 2022a;Chuang et al, 2022b;Lee et al, 2022). Genome-wide analysis of DNA methylation in patients with type 1 diabetes mellitus found that this is associated with PDR (Agardh et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Association of SDF-1 and its receptor CXCR4 polymorphisms on the susceptibility of diabetic retinopathy in the Taiwanese population

Peng,

Chuang,

Hwang

et al. 2023

Front. Genet.

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Stromal cell-derived factor-1 (SDF-1) and its receptor CXC chemokine 4 (CXCR4) have been demonstrated to play critical roles in diabetic retinopathy (DR). This study investigated whether single-nucleotide polymorphisms (SNPs) of SDF-1 and its receptor CXCR4 are correlated with diabetic retinopathy (DR). Three SDF-1 SNPs, namely, rs1801157 (G/A), rs2297630 (G/A), and rs266085 (T/C), and two CXCR4 SNPs, namely, rs2228014 (C/T) and rs6430612 (C/T), were chosen and genotyped via the TaqMan allelic discrimination for 454 non-DR subjects and 276 DR individuals. Our results revealed that subjects carrying SDF-1 SNP rs2297630 GA (AOR: 2.962, 95% CI: 1.279-6.861, p = 0.011) and SDF-1 SNP rs2297630 GA + AA (AOR: 3.095, 95% CI: 1.394-6.872, p = 0.006) had significantly higher risk in the non-proliferative diabetic retinopathy (NPDR) groups than in the non-DR group. Further analyses using the datasets from the Genotype-Tissue Expression (GTEx) Portal revealed that SDF-1 SNP rs2297630 GA and AA genotypic variants have higher SDF-1 expression than the GG wild-type alleles (p = 0.000016). In conclusion, our findings revealed that SDF-1 SNP rs2297630 was associated with NPDR.

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Section: Introductionmentioning

confidence: 99%

Association of SDF-1 and its receptor CXCR4 polymorphisms on the susceptibility of diabetic retinopathy in the Taiwanese population

Peng,

Chuang,

Hwang

et al. 2023

Front. Genet.

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Association of tag single nucleotide polymorphisms (SNPs) at lncRNA MALAT1 with type 2 diabetes mellitus susceptibility in the Chinese Han population: A case-control study

Chang

Zhang²,

Wen³

et al. 2023

Gene

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Genetic association of diabetic retinopathy with long noncoding RNA CDKN2B-AS1 gene polymorphism

Yao,

Chien,

Wang

et al. 2024

European Journal of Ophthalmology

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Aim We attempted to test the influences of cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) gene polymorphisms on the susceptibility to Diabetic retinopathy (DR). Methods Five single-nucleotide polymorphisms (SNPs) of the CDKN2B-AS1 gene, rs564398, rs1333048, rs1537373, rs2151280, and rs8181047 were examined in 280 DR cases and 455 DR-free diabetic controls. Results Among these loci tested, we demonstrated that diabetic carriers of at least one polymorphic allele (G) of rs2151280 (AG and GG; AOR, 1.613; 95% CI, 1.040–2.501; p = 0.033) are more susceptible to proliferative DR but not non-proliferative DR. This genetic association with the risk of developing proliferative DR was further strengthened in homozygotes for the polymorphic allele (G) of rs2151280 (GG; AOR, 2.194; 95% CI, 1.117–4.308; p = 0.023). We detected a significant association of the polymorphic allele (G) of rs2151280 with proliferative DR patients (OR, 1.503; 95% CI, 1.112–2.033; p = 0.008) but not with the entire DR or non-proliferative DR group. Moreover, as compared to those who do not possess the polymorphic allele of rs2151280 (AA), DR patients carrying at least one polymorphic allele of rs2151280 (AG + GG) exhibited a lower glomerular filtration rate and HDL cholesterol level, revealing a promotive role of rs2151280 in renal and cardiovascular complications of diabetes. Conclusion Taken together, our findings implicate an impact of CDKN2B-AS1 gene polymorphisms on the progression of DR.

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Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic Retinopathy

Cited by 5 publications

References 48 publications

Association of SDF-1 and its receptor CXCR4 polymorphisms on the susceptibility of diabetic retinopathy in the Taiwanese population

Association of SDF-1 and its receptor CXCR4 polymorphisms on the susceptibility of diabetic retinopathy in the Taiwanese population

Association of tag single nucleotide polymorphisms (SNPs) at lncRNA MALAT1 with type 2 diabetes mellitus susceptibility in the Chinese Han population: A case-control study

Genetic association of diabetic retinopathy with long noncoding RNA CDKN2B-AS1 gene polymorphism

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