Genetic association of diabetic retinopathy with long noncoding RNA CDKN2B-AS1 gene polymorphism
Yen-Po Yao,
Hsiang-Wen Chien,
Kai Wang
et al.
Abstract:Aim We attempted to test the influences of cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) gene polymorphisms on the susceptibility to Diabetic retinopathy (DR). Methods Five single-nucleotide polymorphisms (SNPs) of the CDKN2B-AS1 gene, rs564398, rs1333048, rs1537373, rs2151280, and rs8181047 were examined in 280 DR cases and 455 DR-free diabetic controls. Results Among these loci tested, we demonstrated that diabetic carriers of at least one polymorphic allele (G) of rs2151280 (AG and GG; A… Show more
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