Impact of Liver Graft Transport on Postoperative Results and Short-Term Liver Survival

Córdoba, María Esther Gámez; Pérez, B. Sánchez; Santoyo-Santoyo, Julio; Aguilar, José Luis Fernández; Muñóz, Miguel Ángel Suárez; Daga, J.A. Pérez; Díaz, F.; Casado, Custodia Montiel

doi:10.1016/j.transproceed.2016.08.019

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…Similarly, when comparing distant versus locally procured liver allografts in Spain, not only was CIT increased, but postoperative bilirubin levels (3.17 mg/mL local vs 4.33 mg/mL distant) and alkaline phosphatase levels (83.95 mg/mL local vs 95.38 mg/mL distant) increased as well [24] . Similarly, a retrospective analysis of pediatric heart transplants between 1987 and 2008 found a negative association between CITs greater than 3.5 hours and allograft survival at 6 months, but not with graft loss beyond this time point [25] . Yet, a retrospective analysis of primary heart transplants performed in the United States between 2000 and 2013 found that increasing donor organ transport distance failed to correlate with perioperative complications, rejection episodes, or 1- and 5-year patient survival.…”

Section: Discussionmentioning

confidence: 92%

Transport-Associated Vibrational Stress Triggers Drug-Reversible Apoptosis and Cardiac Allograft Failure in Mice

Lee

Gavzy

Jang

et al. 2023

IEEE J. Transl. Eng. Health Med.

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Increasingly complex and long-range donor organ allocation routes coupled with implementation of unmanned aerial vehicles (UAVs) have prompted investigations of the conditions affecting organs once packaged for shipment. Our group has previously demonstrated that different modes of organ transport exert unique environmental stressors, in particular vibration. Using a mouse heart transplant model, we demonstrated that vibrational forces exert tangible, cellular effects in the form of cardiomyocyte apoptosis and cytoskeletal derangement. Functionally, these changes translated into accelerated allograft loss. Notably, administration of an apoptosis inhibitor, Z-VAD-FMK, helped to ameliorate the detrimental cellular and functional effects of mechanical vibration in a dose-dependent manner. These findings constitute one of the first reports of the negative impact of transit environment on transplant outcomes, a contributing mechanism underpinning this effect, and a potential agent to prophylax against this process. Given current limitations in measuring donor organ transit environments in situ, further study is required to better characterize the impact of transport environment and to potentially improve the care of donor organs during shipment. Clinical and Translational Impact Statement: We show that apoptosis inhibitor, Z-VAD-FMK, ameliorated transport-related vibrational stress in murine heart transplants, which presents a potential therapeutic or preservation solution additive for future use in transporting donor organs.

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Section: Discussionmentioning

confidence: 92%

Transport-Associated Vibrational Stress Triggers Drug-Reversible Apoptosis and Cardiac Allograft Failure in Mice

Lee

Gavzy

Jang

et al. 2023

IEEE J. Transl. Eng. Health Med.

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“…With the development of novel treatments, newer tissue repairing strategies and biological and synthetic solutions being made available more clinical aids could be possible to patients. However, new promising biomaterial for tissue engineering and stem cell technology are to be developed [181]. Further, inherently suitable scaffolds and matrices are generated for tissue engineering, stem cell propagation and differentiation.…”

Section: Future Clinical Prospectsmentioning

confidence: 99%

Stem Cell Therapeutics of Acute Liver Diseases, Transplantation, and Regeneration

Upadhyay¹

2017

J Cell Sci Ther

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Present review article explains various causes of acute liver diseases and their therapeutics. This article describes major reasons of hepatic pathophysiological conditions and diseases including hepatitis, cholestasis, alcoholic and non-alcoholic steatohepatitis, jaundice, liver cirrhosis, carcinogenesis and many others. This article emphasizes use of proliferating hepatocytes, hepatic oval cells, adult human liver mesenchymal stem/progenitor cells, induced pluripotent stem cells (iPSCs) and hematopoietic stem cells in cell transplantation for restoration of liver structure and function. It also justified the therapeutic role of cell secreted growth factors and dietary factors required during natural healing and regeneration liver after surgery or liver transplantation. It sketches out regulatory roles of signaling pathways, expression of cell cycle regulators, growth factors, cytokines, and role of different mitogens in induction of liver stem/progenitor cells (LSPCs) after organ/stem cell transplantation. This article suggests a need for development of new advanced biomaterials, methods, technologies and stem cells for development of targeted therapies to combat and cure liver related diseases and disorders. This article also advice people for avoiding excessive use of alcohol, drugs, fats, salt, high energy diets, and iron as all are responsible of liver cirrhosis, damage and failure.

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Impact of long-distance (up to 3.500 km) deceased donor liver transportation on cold ischemia time, initial graft function and transplant outcomes

Сушков

Губарев

Виноградов

et al. 2021

Transplantologiâ (Mosk.)

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Rationale. Currently, a long-distance transportation of the deceased donor livers is not a routine practice for Russian transplantation centers; therefore, a research-based analysis of even relatively small single-center experience seems to be a topical task.The study purpose was to evaluate the impact of long-distance donor liver transportation on the cold ischemia time, the initial graft function as well as on immediate and long-term transplant outcomes.Material and methods. The retrospective single-center study included the data on specific features and results of 72 consecutive deceased donor liver transplantations. The cases were allocated into two groups depending on cold ischemia time: for less than 9 hours (group 1; n = 41) and for 9 hours or longer (group 2; n = 31). The parameters of donor organ transportation, characteristics of donors and recipients, specific features of surgery and the early postoperative period, immediate and long-term outcomes were compared between the groups. For the entire sample size, the relationship between the distance from the donor hospital to the transplant center, the transportation type and time, and the cold ischemia time were assessed.Results. Donor livers were delivered from hospitals 40-3500 km away from the transplant center, including by using regular air flights in 67% of cases. Transportation time varied from 1 to 8 h (median 3.5 h), which made 41% (interquartile range: 35-54%) of cold ischemia time.No statistically significant differences between the groups were seen in the donor, recipient and surgery characteristics. The median distance was 509 km in group 1 (interquartile range 130-1321 km), and 1321 in group 2 (interquartile range 897-3441 km), p<0.001; transportation time was 3.5 h (interquartile range : 2.5–4.7 h) and 3.5 h (interquartile range: 3.3–7.0 h), p = 0.022, the cold ischemia time was 8 h (interquartile range: 7–9.5 h) and 10 hours (interquartile range: 9-10.5 h), p <0.001, in group 1 and group 2, respectively, the difference being statistically significant for all parameters. Despite the tendency to increases in the incidence of the early allograft dysfunction (6/41 in group 1, 9/31 in group 2; p = 0.155), primary graft non-function (1/41 in group 1, 3/31 in group 2; p = 0.308), and the graft loss incidence during the first 6 weeks (4/41 in group 1; 7/31 in group 2; p = 0.189), these differences did not reach the statistical significance.Conclusion. The results of this retrospective study have confirmed the feasibility and clinical efficacy of donor liver transplantation after long-distance transportation. However, cold ischemia time exceeding 9 hours is the risk factor for poor initial graft function.

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Impact of Liver Graft Transport on Postoperative Results and Short-Term Liver Survival

Cited by 3 publications

References 11 publications

Transport-Associated Vibrational Stress Triggers Drug-Reversible Apoptosis and Cardiac Allograft Failure in Mice

Transport-Associated Vibrational Stress Triggers Drug-Reversible Apoptosis and Cardiac Allograft Failure in Mice

Stem Cell Therapeutics of Acute Liver Diseases, Transplantation, and Regeneration

Impact of long-distance (up to 3.500 km) deceased donor liver transportation on cold ischemia time, initial graft function and transplant outcomes

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