Impact of liver biopsy size on histological evaluation of chronic viral hepatitis: the smaller the sample, the milder the disease

Influence of Cannabis Use on Severity of Hepatitis C Disease

“…This finding is in keeping with the increasing body of literature that stresses the importance of biopsy adequacy (as measured by length and the number of portal tracts) in the assessment of fibrosis (16,17,32).…”

“…A single pathologist, blinded to clinical data, scored each biopsy for necroinflammation using the Knodell method (scale 0-18) (13), steatosis using the Brunt criteria (14), and fibrosis using the Ishak method (scale F0 to F6) (15). To control for inaccuracy in assessing the stage of fibrosis that was related to biopsy adequacy (16,17), all biopsies were evaluated for length (cm) and the number of portal tracts.…”

Epicardial fat, cardiac geometry and cardiac function in patients with non-alcoholic fatty liver disease: Association with the severity of liver disease

“…A minimum length of 15 mm of biopsy specimen or the presence of at least 10 complete portal tracts was required [22]. Steatosis was assessed as the percentage of hepatocytes containing fat droplets (minimum 5%), and evaluated as continuous variable.…”

Liver fibrosis progression at autopsy in injecting drug users infected by hepatitis C: A longitudinal long-term cohort study

“…Thus sampling bias which could interfere with the evaluation was avoided [25][26][27]. This is, to the best of our knowledge, the first time such information from autopsies has been used in a longitudinal study of fibrosis in IDUs infected by HCV.…”