Impact of lifestyle interventions on depressive symptoms in individuals at-risk of, or with, type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials

Cezaretto, Adriana; Ferreira, Sandra Roberta Gouvêa; Sharma, Shruti; Sadeghirad, Behnam; Kolahdooz, Fariba

doi:10.1016/j.numecd.2016.04.009

Cited by 31 publications

(36 citation statements)

References 81 publications

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“…Study findings showed that the HED-SMART intervention, despite focusing primarily on behavior change, yielded significant benefits by reducing symptoms of depression for both the low stable and high stable groups. This has been shown for self-management programs in other patient group [55]. A similar trend was noted for reduced anxiety, although this failed to reach significance.…”

Section: Discussionsupporting

confidence: 75%

The effect of brief self-management intervention for hemodialysis patients (HED-SMART) on trajectories of depressive and anxious symptoms

Griva

Lam

Mooppil

et al. 2018

Journal of Psychosomatic Research

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Section: Discussionsupporting

confidence: 75%

The effect of brief self-management intervention for hemodialysis patients (HED-SMART) on trajectories of depressive and anxious symptoms

Griva

Lam

Mooppil

et al. 2018

Journal of Psychosomatic Research

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“…19 HRQoL, mental health, self-efficacy, and self-management outcomes were selected based on effects evidence from T2DM self-management intervention reviews and metaanalyses. [24][25][26] Trained research assistants obtained outcome data at baseline and 6 months after the intervention. Component Summary (MCS).…”

Section: Methodsmentioning

confidence: 99%

Community Program Improves Quality of Life and Self‐Management in Older Adults with Diabetes Mellitus and Comorbidity

Markle‐Reid

Ploeg

Fraser

et al. 2017

J American Geriatrics Society

116

105

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ObjectivesTo compare the effect of a 6‐month community‐based intervention with that of usual care on quality of life, depressive symptoms, anxiety, self‐efficacy, self‐management, and healthcare costs in older adults with type 2 diabetes mellitus (T2DM) and 2 or more comorbidities.DesignMultisite, single‐blind, parallel, pragmatic, randomized controlled trial.SettingFour communities in Ontario, Canada.ParticipantsCommunity‐dwelling older adults (≥65) with T2DM and 2 or more comorbidities randomized into intervention (n = 80) and control (n = 79) groups (N = 159).InterventionClient‐driven, customized self‐management program with up to 3 in‐home visits from a registered nurse or registered dietitian, a monthly group wellness program, monthly provider team case conferences, and care coordination and system navigation.MeasurementsQuality‐of‐life measures included the Physical Component Summary (PCS, primary outcome) and Mental Component Summary (MCS, secondary outcome) scores of the Medical Outcomes Study 12‐item Short‐Form Health Survey (SF‐12). Other secondary outcome measures were the Generalized Anxiety Disorder Scale, Center for Epidemiologic Studies Depression Scale (CES‐D‐10), Summary of Diabetes Self‐Care Activities (SDSCA), Self‐Efficacy for Managing Chronic Disease, and healthcare costs.ResultsMorbidity burden was high (average of eight comorbidities). Intention‐to‐treat analyses using analysis of covariance showed a group difference favoring the intervention for the MCS (mean difference = 2.68, 95% confidence interval (CI) = 0.28–5.09, P = .03), SDSCA (mean difference = 3.79, 95% CI = 1.02–6.56, P = .01), and CES‐D‐10 (mean difference = −1.45, 95% CI = −0.13 to −2.76, P = .03). No group differences were seen in PCS score, anxiety, self‐efficacy, or total healthcare costs.ConclusionParticipation in a 6‐month community‐based intervention improved quality of life and self‐management and reduced depressive symptoms in older adults with T2DM and comorbidity without increasing total healthcare costs.

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“…7 Therapeutic lifestyle changes that target diet and exercise are known to positively influence depressed mood. 34,35 We have previously shown that standard cardiac rehabilitation is effective in not only reducing mortality risk but also in reducing depression symptoms in HF, 7 and that other forms of behavioral interventions favorably affect the somatic/affective but not the cognitive/affective depressive symptoms. 17 Given the elevated IL-6, TNF-R1, and sST2 levels in stage B HF patients with both T2DM and depressed mood, additional attention and interventions to forestall potential transition to symptomatic stage C HF may be warranted.…”

Section: Resultsmentioning

confidence: 99%

“…As noted above, depressive symptoms and depressed mood are significant predictors of morbidity and mortality in cardiac and noncardiac populations . Therapeutic lifestyle changes that target diet and exercise are known to positively influence depressed mood . We have previously shown that standard cardiac rehabilitation is effective in not only reducing mortality risk but also in reducing depression symptoms in HF, and that other forms of behavioral interventions favorably affect the somatic/affective but not the cognitive/affective depressive symptoms …”

Section: Discussionmentioning

confidence: 99%

Depressive symptoms in asymptomatic stage B heart failure with Type II diabetic mellitus

Mills

Taub

Lunde

et al. 2019

Clinical Cardiology

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Background The presence of concomitant Type II diabetic mellitus (T2DM) and depressive symptoms adversely affects individuals with symptomatic heart failure (HF). Hypothesis In presymptomatic stage B HF, this study hypothesized the presence of greater inflammation and depressive symptoms in T2DM as compared to non‐T2DM Stage B patients. Methods This cross‐sectional study examined clinical parameters, inflammatory biomarkers, and depressive symptoms in 349 T2DM and non‐T2DM men with asymptomatic stage B HF (mean age 66.4 years ±10.1; range 30‐91). Results Fewer diabetic HF patients had left ventricular (LV) systolic dysfunction ( P < .05) although more had LV diastolic dysfunction ( P < .001). A higher percentage of T2DM HF patients were taking ACE‐inhibitors, beta‐blockers, calcium channel blockers, statins, and diuretics ( P values < .05). T2DM HF patients had higher circulating levels of interleukin‐6 (IL‐6) ( P < .01), tumor necrosis factor‐alpha ( P < .01), and soluble ST2 (sST2) ( P < .01) and reported more somatic/affective depressive symptoms (Beck Depression Inventory II) ( P < .05) but not cognitive/affective depressive symptoms ( P = .20). Among all patients, in a multiple regression analysis predicting presence of somatic/affective depressive symptoms, sST2 ( P = .026), IL‐6 ( P = .010), B‐type natriuretic peptide ( P = .016), and sleep (Pittsburgh Sleep Quality Index [ P < .001]) were significant predictors (overall model F = 15.39, P < .001, adjusted R 2 = .207). Conclusions Somatic/affective but not cognitive/affective depressive symptoms are elevated in asymptomatic HF patients with T2DM patients. Linkages with elevated inflammatory and cardiac relevant biomarkers suggest shared pathophysiological mechanisms among T2DM HF patients with somatic depression, and these conditions are responsive to routine interventions, including behavioral. Copyright © 2019 John Wiley & Sons, Ltd.

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Impact of lifestyle interventions on depressive symptoms in individuals at-risk of, or with, type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials

Abstract: Lifestyle interventions were effective in improving depression among people with T2DM.

Cited by 31 publications

References 81 publications

The effect of brief self-management intervention for hemodialysis patients (HED-SMART) on trajectories of depressive and anxious symptoms

The effect of brief self-management intervention for hemodialysis patients (HED-SMART) on trajectories of depressive and anxious symptoms

Community Program Improves Quality of Life and Self‐Management in Older Adults with Diabetes Mellitus and Comorbidity

Depressive symptoms in asymptomatic stage B heart failure with Type II diabetic mellitus

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