Depressive symptoms in asymptomatic stage B heart failure with Type II diabetic mellitus

Mills, Paul J.; Taub, Pam R.; Lunde, O. C.; Pung, Meredith A.; Wilson, Kathleen; Pruitt, Christopher M.; Rutledge, Thomas; Maisel, Alan S.; Greenberg, Barry

doi:10.1002/clc.23187

Cited by 6 publications

(11 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Individuals with HF have consistently elevated depressed mood and anxiety [21,60], which correlates with significantly poorer clinical outcomes, including morbidity and mortality [61,62]. It may be therefore that for individuals with asymptomatic HF, engaging in spiritual practices (as mindfulness has been recently proposed [63], could help support and improve their clinical symptoms and psychosocial well-being.…”

Section: Discussionmentioning

confidence: 99%

“…Participants were recruited from the cardiology clinics at University of California San Diego (UCSD) and at the Veterans Affairs San Diego Healthcare System (VASDHS) between 2011-2014. The presence of Stage B HF was defined as structural heart disease based on recommendations and cut-points from the American Society of Echocardiography guidelines [20,21].…”

Section: Samplementioning

confidence: 99%

See 1 more Smart Citation

Is Belonging to a Religious Organization Enough? Differences in Religious Affiliation Versus Self-Ratings of Spirituality on Behavioral and Psychological Variables in Individuals with Heart Failure

et al. 2020

Self Cite

View full text Add to dashboard Cite

In the United States, heart failure (HF) affects approximately 6.5 million adults. While studies show that individuals with HF often suffer from adverse symptoms such as depression and anxiety, studies also show that these symptoms can be at least partially offset by the presence of spiritual wellbeing. In a sample of 327 men and women with AHA/ACC classification Stage B HF, we found that more spirituality in patients was associated with better clinically-related symptoms such as depressed mood and anxiety, emotional variables (affect, anger), well-being (optimism, satisfaction with life), and physical health-related outcomes (fatigue, sleep quality). These patients also showed better self-efficacy to maintain cardiac function. Simply belonging to a religious organization independent of spiritualty, however, was not a reliable predictor of health-related benefits. In fact, we observed instances of belonging to a religious organization unaccompanied by parallel spiritual ratings, which appeared counterproductive.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Samplementioning

confidence: 99%

Is Belonging to a Religious Organization Enough? Differences in Religious Affiliation Versus Self-Ratings of Spirituality on Behavioral and Psychological Variables in Individuals with Heart Failure

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Kikuchi and colleagues established an animal model, and found that sST2 overexpression may reduce social behavior and enhance depressive‐like behavior by changing the composition of gut microbiota [34]. Another study conducted in 349 type 2 diabetes mellitus (T2DM) and non‐T2DM men with asymptomatic stage B heart failure (HF) indicated that T2DM HF patients had higher circulating levels of sST2 and had more somatic/affective depressive symptoms [14]. Furthermore, a study including 233 consecutive HF patients demonstrated that sST2 was independently related to depression scores for the Hospital Anxiety and Depression Scale, and patients with both elevated sST2 and depression had a 4.9‐fold increased risk of all‐cause mortality and rehospitalization for HF [35].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that sST2 has the role of enhancing phagocytosis, which could be an important response to vascular injury[12], and higher concentrations of sST2 were associated with incident stroke [13]. It is reported that sST2 is an independent predictor of somatic/affective depression [14]. However, there is sparse literature on the relationship between sST2 level and subsequent depression after ischemic stroke.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Plasma soluble suppression of tumorigenicity 2 and depression after acute ischemic stroke

Qian

Chen

et al. 2021

Euro J of Neurology

View full text Add to dashboard Cite

Background and purpose Soluble suppression of tumorigenicity 2 (sST2) might be related to stroke and depression, but the association of sST2 with poststroke depression (PSD) is unclear. The study aimed to prospectively assess the association between plasma sST2 levels and PSD. Methods A total of 635 acute ischemic stroke patients with sST2 measurements from the China Antihypertensive Trial in Acute Ischemic Stroke were included in this analysis. We used the 24‐item Hamilton Rating Scale for Depression to assess depression at 3 months, and PSD was defined as a score of ≥8. Logistic regression analysis was performed to estimate the risk of PSD associated with sST2, and net reclassification index (NRI) and integrated discrimination improvement (IDI) were calculated to assess the predictive value of sST2. Results Two hundred fifty (39.4%) patients developed depression at 3 months after ischemic stroke. Patients with PSD had higher sST2 levels than patients without PSD (172.7 vs. 153.8 pg/ml; p = 0.003). After adjustment for age, sex, education, National Institutes of Health Stroke Scale score, and other covariates, the odds ratio for the highest quartile of sST2 compared with the lowest quartile was 1.84 (95% confidence interval, 1.10–3.08) for PSD. Adding sST2 to a conventional model notably improved risk prediction for PSD (category‐free NRI = 19.34%, 95% confidence interval = 4.39%–34.28%, p = 0.017; IDI = 1.20%, 95% confidence interval = 0.25%–2.15%, p = 0.014). Conclusions Increased plasma sST2 levels in the acute phase of ischemic stroke were significantly associated with the increased risk of PSD, independently of conventional risk factors.

show abstract

Digestive Enzyme Activity and Protein Degradation in Plasma of Heart Failure Patients

et al. 2021

Self Cite

View full text Add to dashboard Cite

Introduction Heart failure is associated with degradation of cell functions and extracellular matrix proteins, but the trigger mechanisms are uncertain. Our recent evidence shows that active digestive enzymes can leak out of the small intestine into the systemic circulation and cause cell dysfunctions and organ failure. Methods Accordingly, we investigated in morning fasting plasma of heart failure (HF) patients the presence of pancreatic trypsin, a major enzyme responsible for digestion. Results Western analysis shows that trypsin in plasma is significantly elevated in HF compared to matched controls and their concentrations correlate with the cardiac dysfunction biomarker BNP and inflammatory biomarkers CRP and TNF-α. The plasma trypsin levels in HF are accompanied by elevated pancreatic lipase concentrations. The trypsin has a significantly elevated activity as determined by substrate cleavage. Mass spectrometry shows that the number of plasma proteins in the HF patients is similar to controls while the number of peptides was increased about 20% in HF patients. The peptides are derived from extracellular and intracellular protein sources and exhibit cleavage sites by trypsin as well as other degrading proteases (data are available via ProteomeXchange with identifier PXD026332). Connclusions These results provide the first evidence that active digestive enzymes leak into the systemic circulation and may participate in myocardial cell dysfunctions and tissue destruction in HF patients. Conclusions These results provide the first evidence that active digestive enzymes leak into the systemic circulation and may participate in myocardial cell dysfunctions and tissue destruction in HF patients.

show abstract

Depressive symptoms in asymptomatic stage B heart failure with Type II diabetic mellitus

Cited by 6 publications

References 38 publications

Is Belonging to a Religious Organization Enough? Differences in Religious Affiliation Versus Self-Ratings of Spirituality on Behavioral and Psychological Variables in Individuals with Heart Failure

Is Belonging to a Religious Organization Enough? Differences in Religious Affiliation Versus Self-Ratings of Spirituality on Behavioral and Psychological Variables in Individuals with Heart Failure

Plasma soluble suppression of tumorigenicity 2 and depression after acute ischemic stroke

Digestive Enzyme Activity and Protein Degradation in Plasma of Heart Failure Patients

Contact Info

Product

Resources

About