Impact of Laparoscopic CO2-insufflation on Tumor-associated molecules in cultured colorectal cancer cells

Kim, Z.G.; Mehl, C. F. R.; Lorenz, M; Gutt, Carsten N.

doi:10.1007/s00464-001-9194-3

Cited by 22 publications

(14 citation statements)

References 23 publications

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“…This finding suggests that our laparoscopic procedure for D2 lymphadenectomy was sufficient for locally advanced cancer. On the other hand, regarding the recurrence pattern, in vivo studies have shown that laparoscopy with CO 2 insufflation might stimulate the growth of dormant tumor cells into overt liver metastases [34,35]. The pattern in our study might be consistent with the theory that laparoscopy with CO 2 insufflation might trigger the growth of dormant tumor cells into overt liver metastases, however, further experimental studies and clinical data collection are necessary to confirm the different recurrence pattern for LAG.…”

Section: Discussionsupporting

confidence: 84%

Long‐term outcomes after laparoscopy‐assisted gastrectomy for advanced gastric cancer: Analysis of consecutive 106 experiences

Lee

Kim

2009

Journal of Surgical Oncology

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Background and Objectives: The purpose of this retrospective study is to suggest the possibility of laparoscopy-assisted gastrectomy (LAG) for advanced gastric cancer (AGC) through long-term outcomes. Methods: Of 283 patients with gastric cancer who underwent LAG with extraperigastric (D2) lymphadenectomy between January 2004 and February 2009, 106 were pathologically confirmed with AGC and analyzed. Results: There were 75 men and 31 women, with a mean age of 61.4 AE 11.7 years. There were 32 total gastrectomies and 74 distal gastrectomies with D2 lymphadenectomy. The mean tumor size was 4.8 AE 2.6 cm. The mean numbers of retrieved and metastatic lymph nodes were 34.3 AE 15.3 and 5.4 AE 8.7, respectively. There was no lymph node metastasis in 44 patients (41.5%), and there were 35 grade T2a, 51 T2b, and 20 T3 lesions. There were 10 operation-related morbidities (9.4%) and one postoperative death (0.9%) from hepatic failure. The overall and disease-free survival rates were 81.4% and 72.4%, respectively. Tumors recurred in 17 patients (16.0%) during the follow-up periods (median 21.5 months; range 2-60). Conclusions: LAG for AGC might be considered as a minimally invasive treatment in selected cases, but further study comparing it with open gastrectomy will be needed.

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Section: Discussionsupporting

confidence: 84%

Long‐term outcomes after laparoscopy‐assisted gastrectomy for advanced gastric cancer: Analysis of consecutive 106 experiences

Lee

Kim

2009

Journal of Surgical Oncology

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“…These results suggest that our procedure for lymphadenectomy was sufficient for T2b cancer. On the other hand, regarding the recurrence pattern, several in vivo studies have shown laparoscopy with carbon dioxide insufflations seemed to stimulate the growth of dormant tumor cells into overt liver metastases [24,25]. However, further experimental studies and clinical data collection are necessary to confirm the different recurrence pattern between the two groups.…”

Section: Journal Of Surgical Oncologymentioning

confidence: 95%

Laparoscopy‐assisted distal gastrectomy with D2 lymphadenectomy for T2b advanced gastric cancers: Three Years' experience

Hur

Jeon

Kim

2008

Journal of Surgical Oncology

108

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“…The design of the experiments, with placement of HA membrane on non-traumatized peritoneum, additionally allowed to study this. The effect of HA itself seems dualistic based on its interactions with the surface receptor CD44, which is present on a variety [20,21]. Zeng et al [22] demonstrated that tumour growth can be inhibited in vivo by HA oligomers, probably due to an effect on the interaction of endogenous HA and CD44.…”

Section: Discussionmentioning

confidence: 99%

Hyaluronan-Based Antiadhesive Membrane Has No Major Effect on Intraperitoneal Growth of Colonic Tumour Cells

Sikkink¹,

Postma²,

Reijnen³

et al. 2004

Eur Surg Res

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Background: A relationship between post-surgical adhesion formation and peritoneal tumour implantation has been proposed. Hyaluronan (HA)-based agents reduce adhesion formation, but the effect on peritoneal tumour is not established. This study investigated the influence of a HA-containing agent on intraperitoneal tumour in an experimental model. Methods: 66 Balb/c mice underwent laparotomy and damage was inflicted to the parietal peritoneum. The animals were randomized into five groups. Groups 1 and 2 received HA-carboxymethylcellulose bioresorbable membrane and no treatment, respectively. Mice in groups 3–5 were injected intraperitoneally with 10⁵ colon 26-B cells after the laparotomy. Treatment consisted of HA membrane, no HA agent and placement of HA membrane on the non-traumatized peritoneal wall, respectively. Animals were killed after 14 days; adhesions were scored in groups 1 and 2, and the tumour mass in groups 3–5. 45 Wag/Rij rats underwent the same procedures and treatment as mice in groups 3–5. In rats, 10⁶ CC-531 cells were injected. Rats were killed after 3 weeks and the tumour mass was scored. Results: HA membrane resulted in a significant reduction of adhesions, but had no major effect on the intraperitoneal tumour mass in mice and rats. Conclusion: HA-carboxymethylcellulose bioresorbable membrane has no major effect on intraperitoneal tumour implantation and growth in an experimental model.

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Impact of Laparoscopic CO2-insufflation on Tumor-associated molecules in cultured colorectal cancer cells

Abstract: The present study demonstrates CO2-insufflation to influence the expression of E-cadherin, I-CAM1 and CD44. Whether these changes increases the metastatic potential of colorectal cancer cells in vivo needs further investigation.

Cited by 22 publications

References 23 publications

Long‐term outcomes after laparoscopy‐assisted gastrectomy for advanced gastric cancer: Analysis of consecutive 106 experiences

Long‐term outcomes after laparoscopy‐assisted gastrectomy for advanced gastric cancer: Analysis of consecutive 106 experiences

Laparoscopy‐assisted distal gastrectomy with D2 lymphadenectomy for T2b advanced gastric cancers: Three Years' experience

Hyaluronan-Based Antiadhesive Membrane Has No Major Effect on Intraperitoneal Growth of Colonic Tumour Cells

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