Impact of intraocular pressure regulation on visual fields in open-angle glaucoma11The authors have no proprietary interest in any of the materials used in this study.

Bergeå, Bengt; Bodin, Lennart; Svedbergh, Björn

doi:10.1016/s0161-6420(99)00523-0

Cited by 154 publications

(27 citation statements)

References 26 publications

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“…The study clearly showed the utility of performing daytime curves with respect to single IOP measurements, and suggested that also peak and fluctuation are parameters to be controlled to reduce the likelihood of glaucoma progression. Our confirmatory results extend the conclusions drawn by Bergeå et al [12 ]into more updated treatments. The relevance of the role of peak and fluctuation may be even higher considering that prostaglandin analogues are known to flatten the 24-hour IOP curve [21].…”

Section: Discussionsupporting

confidence: 92%

“…Interestingly, our data largely overlap with those of Bergeå et al [12], who, similarly to this study, observed glaucoma patients with daytime curves every 6 months over a period of 24 months. The study clearly showed the utility of performing daytime curves with respect to single IOP measurements, and suggested that also peak and fluctuation are parameters to be controlled to reduce the likelihood of glaucoma progression.…”

Section: Discussionsupporting

confidence: 88%

“…It has recently been suggested that peak IOP may be a better predictor of progression than mean IOP [10], because it would better quantify the exposure of the eye to higher than endurable values. A similar hypothesis was suggested also for fluctuations, although their role as an independent risk factor is still an object of debate [8,9,10,11,12,13,14,15]. Few studies calculated ST fluctuation from diurnal curves [11,16], others [12,13,14] calculated LT fluctuation from a series of single IOP measurements during consecutive visits, but none of the studies aiming at demonstrating the role of IOP fluctuation on the progression of glaucoma was based on 24-hour curves.…”

Section: Introductionmentioning

confidence: 72%

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Short- and Long-Term Phasing of Intraocular Pressure in Stable and Progressive Glaucoma

et al. 2013

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Aims: To evaluate short- (ST) and long-term (LT) intraocular pressure (IOP) in patients with stable (SG) and progressive glaucoma (PG). Materials and Methods: Fifty-two patients with treated glaucoma received a baseline 24-hour IOP curve and, every 6 months for 2 years, office-hour curve plus visual field test. Based on field changes, they were divided into 24 SG and 28 PG. ST and LT IOP mean, peak and fluctuation (standard deviation of measurements) were calculated. Parameters determining progression were evaluated by logistic regression. Results: At ST, SG and PG, respectively, had mean IOP of 16.8 ± 2.2 and 15.3 ± 1.8 mm Hg; peak of 19.7 ± 3.3, 17.4 ± 2.3 mm Hg; fluctuation of 2.3 ± 1.2, and 1.6 ± 0.6 mm Hg. LT parameters did not change in SG, whereas a significant increase of mean (+1.0 ± 1.5 mm Hg, p = 0.05), peak (2.0 ± 2.4 mm Hg, p = 0.0002), and fluctuation (0.5 ± 1.1 mm Hg, p = 0.008) occurred in PG. Mean, peak, and fluctuation were correlated, except mean and fluctuation in the long term. Association with progression was shown for change in mean IOP between ST and LT, and ST peak. Conclusions: SG and PG may show different IOP parameters when intensively measured at baseline and follow-up. Mean IOP change between ST and LT periods and ST peak were the parameters associated with progression.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 72%

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Short- and Long-Term Phasing of Intraocular Pressure in Stable and Progressive Glaucoma

et al. 2013

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“…Therefore there must be an effect of trabeculectomy other than it's effect on the weighted mean IOP. It could be an effect mediated through decreased variation of IOP compared to eyes not operated on (Migdal & Hitchings 1986;Bergeå et al 1999) or through better patient compliance.…”

Section: Discussionmentioning

confidence: 99%

Intraocular pressure and progression in exfoliative eyes with ocular hypertension or glaucoma

Harju¹

2000

Acta Ophthalmologica Scandinavica

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“…Other causes of failure of medical therapy include lack of diurnal control, delayed efficacy and systemic side effects [45,46]. …”

Section: Medical Treatment Of Glaucomamentioning

confidence: 99%

Glaucoma: Present Challenges and Future Trends

Bettin

Matteo

2013

Ophthalmic Res

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The authors indicate four key issues which, in their opinion, represent the most stimulating challenges in the field of glaucoma today, and describe the present approaches and the developments that can be expected or advised in the near future: (1) Glaucoma is often undiagnosed or diagnosed too late. Accurate detection is crucial to correctly recognize and treat affected subjects, thus reducing the disability and the social burden of the disease. Is glaucoma screening advisable and cost-effective? What strategies can be implemented to achieve an earlier diagnosis? (2) What role can genetics play in glaucoma clinics? (3) What are the fundamentals and the limits of medical hypotensive and nonhypotensive treatment of glaucoma today, and what novelties could be introduced in the next few years? (4) What are the current and future options for glaucoma surgery? Should we aim at reducing aqueous production or at enhancing aqueous outflow? What are the success figures and the pros and cons of ab externo procedures with external filtration (trabeculectomy, nonpenetrating techniques and glaucoma drainage devices) and of ab externo techniques with internal filtration (viscocanalostomy and canaloplasty)? Will microinvasive procedures ever play a role in the treatment of the disease? These questions and the possible future developments in the management of glaucoma are discussed critically, based on the current clinical state of the art, on a review of the literature, and on an everyday experience in a busy university hospital glaucoma service.

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Impact of intraocular pressure regulation on visual fields in open-angle glaucoma11The authors have no proprietary interest in any of the materials used in this study.

Cited by 154 publications

References 26 publications

Short- and Long-Term Phasing of Intraocular Pressure in Stable and Progressive Glaucoma

Short- and Long-Term Phasing of Intraocular Pressure in Stable and Progressive Glaucoma

Intraocular pressure and progression in exfoliative eyes with ocular hypertension or glaucoma

Glaucoma: Present Challenges and Future Trends

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