Impact of Inter- and Intramuscular Fat on Muscle Architecture and Capacity

Jiang, Zhenyu; Marriott, Kendal; Maly, Monica R.

doi:10.1615/critrevbiomedeng.2020031124

Cited by 9 publications

(5 citation statements)

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“…Fat accumulation within the muscle may increase volume while limiting the ability of contractile units to generate force 11 . Currently, we do not know if fatty infiltration is greater among patients with HRGP compared to asymptomatic people, however a recent systematic review suggests that, in general, fatty infiltration is greater among patients with a health condition, such as soft tissue impairments, inflammatory disease and mobility impairments, compared to healthy individuals 12 . Specific to musculoskeletal conditions, excessive fatty infiltration has been displayed in musculature of patients with cervical pain due to whiplash, 13 low back pain, 14 greater trochanteric pain syndrome 15 and hip OA 3,16–19 .…”

Section: Introductionmentioning

confidence: 99%

“…11 Currently, we do not know if fatty infiltration is greater among patients with HRGP compared to asymptomatic people, however a recent systematic review suggests that, in general, fatty infiltration is greater among patients with a health condition, such as soft tissue impairments, inflammatory disease and mobility impairments, compared to healthy individuals. 12 Specific to musculoskeletal conditions, excessive fatty infiltration has been displayed in musculature of patients with cervical pain due to whiplash, 13 low back pain, 14 greater trochanteric pain syndrome 15 and hip OA. 3,[16][17][18][19] Although the mechanism underlying each of these health conditions differ, it is possible the presence of chronic HRGP is associated with fat accumulation in the musculature surrounding the painful joint and therefore a potential target for treatment.…”

Section: Introductionmentioning

confidence: 99%

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Comparison between movement pattern training and strengthening on muscle volume, muscle fat, and strength in patients with hip‐related groin pain: An exploratory analysis

Koch

Semciw

Commean

et al. 2021

Journal Orthopaedic Research

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The purpose of this exploratory analysis was to compare the impact of movement pattern training (MoveTrain) and standard strength and flexibility training (Standard) on muscle volume, strength and fatty infiltration in patients with hip-related groin pain (HRGP). We completed a secondary analysis of data collected during an assessor-blinded randomized control trial. Data were used from 27 patients with HRGP, 15-40 years, who were randomized into MoveTrain or Standard groups. Both groups participated in their training protocol (MoveTrain, n = 14 or Standard, n = 13) which included 10 supervised sessions over 12 weeks and a daily home exercise program. Outcome measures were collected at baseline and immediately after treatment. Magnetic resonance images data were used to determine muscle fat index (MFI) and muscle volume. A hand-held dynamometer was used to assess isometric hip abductor and extensor strength. The Standard group demonstrated a significant posttreatment increase in gluteus medius muscle volume compared to the MoveTrain group. Both groups demonstrated an increase in hip abductor strength and reduction in gluteus minimus and gluteus maximus MFI. The magnitude of change for all outcomes were modest. Statement of Clinical Significance: Movement pattern training or a program of strength/flexibility training may be effective at improving hipabductor strength and reducing fatty infiltration in the gluteal musculature among those with HRGP. Further research is needed to betterunderstand etiology of strength changes and impact of muscle volume and MFI in HRGP and the effect of exercise on muscle structure andfunction.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison between movement pattern training and strengthening on muscle volume, muscle fat, and strength in patients with hip‐related groin pain: An exploratory analysis

Koch

Semciw

Commean

et al. 2021

Journal Orthopaedic Research

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“…Presently, with improvements in consumer living standards, the demand for pork has changed from quantity to quality with IMF content representing an important determinant of meat quality [ 1 , 2 ]. Previous studies have indicated that [ 51 , 52 , 53 ] compared with Western commercial pigs (WECPs), Chinese indigenous pigs (CHIPs) displayed better pork quality traits in terms of IMF percentage, 24 h drip loss, meat colour and pH value while WECPs were better in terms of lean meat percentage (BFT and loin eye area) ( Table 3 ).…”

Section: Discussionmentioning

confidence: 99%

“…Pork meat accounts for 40% of the world’s meat consumption and is one of the main sources of protein, fat, and iron for humans (FAO, Rome, Italy, ) (accessed on 13 June 2021). Its quality influences consumer preferences; a high level of marbling or intramuscular fat (IMF) content is positively correlated with meat juiciness, flavour intensity, and tenderness [ 1 , 2 ]. Therefore, IMF content is considered a crucial indicator of porcine meat quality [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

miR-381-3p Inhibits Intramuscular Fat Deposition through Targeting FABP3 by ceRNA Regulatory Network

Jiang

Liu

et al. 2022

Biology

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Intramuscular fat (IMF) deposition is an important determinant of pork quality and a complex process facilitated by non-coding ceRNAs. In this study, 52 Berkshire × Anqing Sixwhite crossbred pigs were slaughtered to measure eight carcass and pork quality traits. Whole-transcriptome sequencing analysis was performed using longissimus dorsi samples of six low- and high-IMF samples; 34 ceRNA networks, based on 881, 394, 158 differentially expressed (DE) lncRNAs, miRNAs, and mRNAs, were constructed. Following weighted gene co-expression network analysis between the low and high IMF, only one ceRNA, lncRNA4789/miR-381-3p/FABP3, that showed similar DE trend in longissimus dorsi tissue was retained. Dual-luciferase reporter assays further indicated that FABP3 was a direct, functional target of miR-381-3p, where miR-381-3p overexpression inhibited the mRNA and protein expression of FABP3. In addition, overexpressed lncRNA4789 attenuated the effect of miR-381-3p on FABP3 by sponging miR-381-3p. Cell function verification experiment demonstrated that miR-381-3p suppressed IMF deposition by inhibiting preadipocyte cell differentiation and lipid droplet deposition via the suppression of FABP3 expression in the peroxisome proliferator-activated receptor signalling pathway, whereas lncRNA4789 rescued FABP3 expression by sponging miR-381-3p. Our study may aid in identifying novel molecular markers for its optimization in IMF which is of importance in breeding for improving pork quality.

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“…Increased ectopic fat deposition leads to decreased tissue function and even disease ( 2 , 3 ). For instance, excessive IMF deposition cause skeletal muscle aging ( 4 ), decreasing muscle strength ( 5 ), systemic insulin resistance ( 6 ) and increasing the risk of multiple diseases, such as COVID-19 ( 7 ), rheumatoid joints ( 8 ), diabetes ( 9 ). Pigs are ideal models for exploring human diseases, with similar physiological structures to human.…”

Section: Introductionmentioning

confidence: 99%

Identification of potential miRNA-mRNA regulatory network and the key miRNAs in intramuscular and subcutaneous adipose

Feng

Liu²,

Yousuf³

et al. 2022

Front. Vet. Sci.

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Intramuscular fat (IMF) is an important indicator for evaluating meat quality. Breeds with high IMF content are often accompanied by high subcutaneous fat (SCF), severely affecting the meat rate of pigs. Studying the mechanisms of miRNAs related to lipogenesis and lipid metabolism has important implications for pig breeding. We constructed two small RNA libraries from intramuscular and subcutaneous fat to evaluate the patterns of lipogenesis in Laiwu pig, a Chinese breed. A total of 286 differentially expressed miRNAs (DEmiRNAs), including 193 known miRNA and 93 novel miRNAs, were identified from two types of adipose. GO and KEGG enrichment analysis for DEmiRNAs showed that their target genes involved in many adipogenesis and lipid metabolism biological processes and signaling pathways, such as Wnt signaling pathway,MAPK signaling pathway, Hippo signaling pathway, PI3K-Akt signaling pathway, Melanogenesis, Signaling pathways regulating pluripotency of stem cells and so on. Then, we constructed a miRNA-mRNA interaction network to find out which miRNAs were the key miRNAs of regulation in Wnt signaling pathway. In this pathway, miR-331-3p, miR-339-5p, miR-874 and novel346_mature target PPARD, WNT10B, RSPO3, WNT2B. This study provides a theoretical basis for further understanding the post-transcriptional regulation mechanism of meat quality formation and predicting and treating diseases caused by ectopic fat.

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Impact of Inter- and Intramuscular Fat on Muscle Architecture and Capacity

Cited by 9 publications

References 0 publications

Comparison between movement pattern training and strengthening on muscle volume, muscle fat, and strength in patients with hip‐related groin pain: An exploratory analysis

Comparison between movement pattern training and strengthening on muscle volume, muscle fat, and strength in patients with hip‐related groin pain: An exploratory analysis

miR-381-3p Inhibits Intramuscular Fat Deposition through Targeting FABP3 by ceRNA Regulatory Network

Identification of potential miRNA-mRNA regulatory network and the key miRNAs in intramuscular and subcutaneous adipose

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