2022
DOI: 10.3389/fvets.2022.976603
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Identification of potential miRNA-mRNA regulatory network and the key miRNAs in intramuscular and subcutaneous adipose

Abstract: Intramuscular fat (IMF) is an important indicator for evaluating meat quality. Breeds with high IMF content are often accompanied by high subcutaneous fat (SCF), severely affecting the meat rate of pigs. Studying the mechanisms of miRNAs related to lipogenesis and lipid metabolism has important implications for pig breeding. We constructed two small RNA libraries from intramuscular and subcutaneous fat to evaluate the patterns of lipogenesis in Laiwu pig, a Chinese breed. A total of 286 differentially expresse… Show more

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Cited by 7 publications
(3 citation statements)
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References 61 publications
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“…In this study, the sheep transcriptome was screened for differential AS event through a deep sequencing-based approach, the sequencing-by-synthesis (SBS) technique offered by Illumina platforms. This has been proven to be a highly accurate means of sequencing [ [10] , [11] , [12] , [13] , [25] , [26] , [27] , [28] ]. We selected the Han and Dorset sheep in this study because of their significantly different growth rates and fat content.…”
Section: Discussionmentioning
confidence: 99%
“…In this study, the sheep transcriptome was screened for differential AS event through a deep sequencing-based approach, the sequencing-by-synthesis (SBS) technique offered by Illumina platforms. This has been proven to be a highly accurate means of sequencing [ [10] , [11] , [12] , [13] , [25] , [26] , [27] , [28] ]. We selected the Han and Dorset sheep in this study because of their significantly different growth rates and fat content.…”
Section: Discussionmentioning
confidence: 99%
“…Overexpression of miR-196a can increase lipid accumulation and promote preadipocyte differentiation [ 93 ]. miR-331, a microRNA participating in regulating the proliferation, differentiation and fatty-acid accumulation of porcine preadipocytes, was up-regulated in the adipose tissues of high-FE pigs [ 94 ]. Overexpressing miR-331 can increased fatty-acid synthesis [ 95 ].…”
Section: Discussionmentioning
confidence: 99%
“…Regarding the role of transcription factors and miRNAs, beef cattle, sheep and pigs all involve PPARγ, miRNAs and other transcription factors in regulating lipid metabolism and IMF content (Duckett & Greene, 2022; Feng et al., 2022; Han et al., 2021). While these commonalities exist, there are differences in how these factors operate in each species.…”
Section: Comparative Genomics With Other Livestock Speciesmentioning
confidence: 99%