Impact of insecticide interventions on the abundance and resistance profile of Aedes aegypti

Abstract

Insecticide-based vector control is the primary strategy for curtailing dengue transmission. We used a mathematical model of the seasonal population dynamics of the dengue mosquito vector, Aedes aegypti, both to assess the effectiveness of insecticide interventions on reducing adult mosquito abundance and to predict evolutionary trajectories of insecticide resistance. We evaluated interventions that target larvae, adults, or both. We found that larval control and adult control using ultra-low-volume insecticide applications can reduce adult mosquito abundance with effectiveness that depends on the frequency of applications. We also found that year-long continuous larval control and adult control, using either insecticide treatment of surfaces and materials or lethal ovitraps, imposed the greatest selection for resistance. We demonstrated that combined targeting of larvae and adults at the start of the dengue season is optimal. This intervention contrasts with year-long continuous larval control policies adopted in settings in which dengue transmission occurs.

Intraspecific Competition and Population Dynamics of Aedes aegypti

“…This result corroborates the findings of Luz et al [8]. Unfortunately, such high rates of intraspecific competition also trigger the evolution of the population, which adapts to new environmental conditions, as indicated by Fig.…”

“…This effect has already been noted by Rivero et al [7] and by Luz et al [8], who discussed the effectiveness of insecticides for vector control and showed that the insecticide affects the rate of competition. Those who survive become more resistant, which leads to specialization.…”

An optimal control model of mosquito reduction management in a dengue endemic region

“…We highlight, for instances, the utilization of ultra low volume (ULV) insecticide [15] combined with temephos [22], also the sterile insect technique (SIT) [7,18,21,10] as a Genetic-based Vector Control (GVC). However, in this paper we do not take the epidemiology within mosquito population, i.e.…”

Potential impact of a presumed increase in the biting activity of dengue-virus-infected Aedes aegypti (Diptera: Culicidae) females on virus transmission dynamics

“…In the current study, we used a simplified version of a previously developed model (Luz et al 2009 to examine the potential impact of this increased activity level of dengue-virus-infected mosquitoes on dengue transmission dynamics. A complete description of this model is beyond the scope of this short communication and can be found in the above-mentioned references.…”

“…Seasonality is built into the transition rates between model compartments. Weather data from Rio de Janeiro were used to parameterise the temporal pattern of the transition rates, which were mathematically defined as sinusoidal functions (Luz et al 2009). The transition rate from egg to larva (t EL ) follows the pattern for precipitation because eggs hatch in response to water.…”