Impact of increased admission lipid levels on periprocedural myocardial injury following an elective percutaneous coronary intervention

Buturak, Ali; Değirmencioğlu, Aleks; Ertürk, Mehmet; Karakurt, Huseyin; Demir, Ali Rza; Surgit, Özgür; Püşüroğlu, Hamdi; Akgül, Özgür; Serteser, Mustafa; Norgaz, Tugrul; Görgülü, Şevket

doi:10.1097/mca.0000000000000235

Cited by 6 publications

(6 citation statements)

References 30 publications

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“…Li et al found that the low preprocedural LDL-C levels were correlated with lower risk of PMI in PCI patients, and the risk of postprocedural cTnI elevation was increased by 12% to 20% due to increased 1-SD in LDL-C [ 13 ]. Similarly, Buturak et al also observed a direct connection between preprocedural LDL-C levels and PMI in PCI patient with stable angina pectoris [ 18 ]. A cohort study that enrolled 302 consecutive patients reported that the ratios of LDL-C to high-density lipoprotein cholesterol (LDL-C/HDL-C) were significantly associated with PMI following elective PCI [ 19 ].…”

Section: Discussionmentioning

confidence: 96%

Relationship Between Preoperative Low-Density Lipoprotein Cholesterol and Periprocedural Myocardial Injury in Patients Following Elective Percutaneous Coronary Intervention in Southern China

et al. 2018

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BackgroundPeriprocedural myocardial injury (PMI) is known to be a predictor of postprocedural cardiovascular morbidity and mortality following a percutaneous coronary intervention (PCI). However, the correlation between low-density lipoprotein cholesterol and periprocedural myocardial injury in patients following elective PCI in southern China remains unclear. Therefore, we aimed to investigate the association of preoperative low-density lipoprotein cholesterol (LDL-C) levels with PMI in patients following elective PCI.Material/MethodsThis study included 1942 consecutive patients who received elective PCI. Cardiac troponin I (cTnI) was used to assess perioperative myocardial injury. The peak cTnI was measured within 24 h after PCI, and the correlation between the cTnI value and the preoperative LDL level was studied.ResultsThe data suggest that the PCI patients with preprocedural LDL-C <100 mg/dl were strongly and independently correlated with less risk of PMI. Univariate logistic regression indicated that patients with preprocedural LDL-C of 70~99 mg/dl were correlated with lower risk of postprocedural cTnI elevation above 3×ULN (odds ratio [OR]: 0.762; 95% [CI]: 0.603–0.965; P<0.024) up to 20×ULN (OR: 0.730; 95% CI: 0.576–0.924; P<0.000) compared to those with preprocedural LDL-C ≥100 mg/dl. Moreover, patients with preprocedural LDL-C of <70 mg/dl were more strongly correlated with lower risk of postprocedural cTnI elevation above 3×ULN (OR: 0.641; 95% CI: 0.436–0.936; P<0.021) up to 20×ULN (OR: 0.476; 95% CI: 0.316–0.717; P<0.000).ConclusionsOur study demonstrated that PCI patients with lower preprocedural LDL-C were correlated with a lower risk of PMI in southern China.

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Section: Discussionmentioning

confidence: 96%

Relationship Between Preoperative Low-Density Lipoprotein Cholesterol and Periprocedural Myocardial Injury in Patients Following Elective Percutaneous Coronary Intervention in Southern China

et al. 2018

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“…7 Buturak et al also demonstrated that the concentrations of preprocedural LDL-C were positively related to PMI in PCI patients. 18 Experimental evidences had confirmed that non-HDL-C is a strong predictor for cardiovascular disease risk assessment. 19,20 Li et al and Maadani et al 7,21 previously confirmed that low non-HDL-C concentrations were associated with less risk of PMI in CAD patients and was higher in PMI patients after PCI.…”

Section: Discussionmentioning

confidence: 98%

Association of serum laboratory parameters with periprocedural myocardial infarction after a primary percutaneous coronary intervention

et al. 2022

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Background Periprocedural myocardial infarction (PMI) is one of the mortality-related complications of percutaneous coronary intervention (PCI) and significantly affects short- and long-term adverse outcomes and immediate cardiovascular events. Our present study aimed to evaluate the association of preprocedural serum laboratory parameters and PMI in patients who received primary PCI and attempted to provide detailed data on the predictors of PCI-related PMI. Methods A total of 1184 consecutive coronary artery disease (CAD) patients who received primary and elective PCI between July 2015 and June 2017 were included and divided into control group and PMI group. The data of serum laboratory parameters were collected from the electronic database of Meizhou People’s Hospital. Results The results indicated that preprocedural fasting blood glucose were higher in PMI group compared with the control group ( p < .001). Patients with prior hyperlipidemia were more likely to have experienced PCI-related PMI ( p = .018) and the preprocedural level of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-HDL-C, apolipoprotein B (Apo B), and LDL-C/high density lipoprotein cholesterol (HDL-C) were significantly enhanced in PMI group ( p < .001). Multivariate regression analysis revealed that preprocedural fasting blood glucose > 6.11 mmol/L ( p < .001, OR = 1.949, 95% CI: 1.444–2.630) and LDL-C levels ≥130 mg/dL ( p = .005, OR = 1.941, 95% CI: 1.217–3.098) independently predicted PCI-related PMI. Conclusion Our results indicated preprocedural fasting blood glucose >6.11 mmol/L and LDL-C levels ≥130 mg/dL may be useful predictors for PCI-related PMI. The study may provide a detailed data on the predictors of PCI-related PMI.

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“…Type 4a MI was defined as elevation of hscTnT values greater than five times the 99 th percentile URL in patients with normal baseline values (≤99 th percentile URL) or a rise of hscTnT values >20% if the baseline values are elevated and are stable or falling in addition to clinical and/or laboratory findings indicative of myocardial ischemia ( 25 ). PMI was defined as previously described ( 2 , 7 – 9 ). Accordingly, after exclusion of patients with elevated baseline troponin values, we categorized the participants into three groups based on post-procedural serum hscTnT concentrations:…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, clinical and procedural factors that may lead to PMI have been investigated to improve clinical outcomes in patients undergoing elective PCI. Although periprocedural side branch occlusion, coronary dissection, distal embolization, and no-reflow during stenting are well known factors to be related to PMI, actual data also indicate that metabolic status of the patient such as admission dyslipidemia, abnormal glucose levels, and albuminuria are associated with PMI in patients undergoing elective PCI ( 6 – 9 ).…”

Section: Introductionmentioning

confidence: 99%

Elective percutaneous coronary intervention leads to significant changes in serum resistin, leptin, and adiponectin levels regardless of periprocedural myocardial injury: an observational study

et al. 2016

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Objective:Bioactive roles of adipokines in coronary atherosclerosis and acute coronary syndromes have been demonstrated previously. However, there is a lack of data regarding the relationship between serum adipokines and periprocedural myocardial injury (PMI) following elective percutaneous coronary intervention (PCI). Therefore, we aimed to investigate the association between serum adipokines and PMI related to elective PCI.Methods:In total, 153 consecutive patients (aged 60.6±8.2 years, 98 men) with stable angina pectoris undergoing elective PCI were enrolled in this observational cross-sectional study. Serum resistin, leptin, adiponectin, and high-sensitive Troponin T (hscTnT) levels were measured immediately before PCI and after 12-h PCI. The no-injury, PMI, and type 4a myocardial infarction (type 4a MI) groups were defined as groups consisting patients with post-procedural hscTnT concentrations <14 ng/L, between 14–70 ng/L, and >70 ng/L, respectively.Results:Serum hscTnT, resistin, and leptin concentrations significantly (p<0.001) increased while serum adiponectin levels decreased (p<0.001) after 12-h elective PCI. However, no correlation was found between post-procedural hscTnT concentrations and resistin, leptin, and adiponectin levels. The no-injury group consisted of 65 patients (42.4%), whereas PMI and type 4a MI were observed in 70 (45.8%) and 18 (11.8%) patients, respectively. The average pre-procedural and post-procedural resistin, leptin, and adiponectin levels did not show any significant difference in the no-injury, PMI, and type 4a MI groups.Conclusion:There is no correlation between serum adipokine levels and post-procedural troponin elevations reflecting PMI or type 4a MI. However, serum resistin and leptin levels increase, whereas adiponectin levels decrease significantly after elective PCI.

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Impact of increased admission lipid levels on periprocedural myocardial injury following an elective percutaneous coronary intervention

Abstract: The present study indicates that increased preprocedural TC, LDL-C, and TG serum levels are associated with PMI and its severity following elective PCI.

Cited by 6 publications

References 30 publications

Relationship Between Preoperative Low-Density Lipoprotein Cholesterol and Periprocedural Myocardial Injury in Patients Following Elective Percutaneous Coronary Intervention in Southern China

Relationship Between Preoperative Low-Density Lipoprotein Cholesterol and Periprocedural Myocardial Injury in Patients Following Elective Percutaneous Coronary Intervention in Southern China

Association of serum laboratory parameters with periprocedural myocardial infarction after a primary percutaneous coronary intervention

Elective percutaneous coronary intervention leads to significant changes in serum resistin, leptin, and adiponectin levels regardless of periprocedural myocardial injury: an observational study

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