Association of serum laboratory parameters with periprocedural myocardial infarction after a primary percutaneous coronary intervention

Abstract

Background Periprocedural myocardial infarction (PMI) is one of the mortality-related complications of percutaneous coronary intervention (PCI) and significantly affects short- and long-term adverse outcomes and immediate cardiovascular events. Our present study aimed to evaluate the association of preprocedural serum laboratory parameters and PMI in patients who received primary PCI and attempted to provide detailed data on the predictors of PCI-related PMI. Methods A total of 1184 consecutive coronary artery disease (CAD) patients who received primary and elective PCI between July 2015 and June 2017 were included and divided into control group and PMI group. The data of serum laboratory parameters were collected from the electronic database of Meizhou People’s Hospital. Results The results indicated that preprocedural fasting blood glucose were higher in PMI group compared with the control group ( p < .001). Patients with prior hyperlipidemia were more likely to have experienced PCI-related PMI ( p = .018) and the preprocedural level of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-HDL-C, apolipoprotein B (Apo B), and LDL-C/high density lipoprotein cholesterol (HDL-C) were significantly enhanced in PMI group ( p < .001). Multivariate regression analysis revealed that preprocedural fasting blood glucose > 6.11 mmol/L ( p < .001, OR = 1.949, 95% CI: 1.444–2.630) and LDL-C levels ≥130 mg/dL ( p = .005, OR = 1.941, 95% CI: 1.217–3.098) independently predicted PCI-related PMI. Conclusion Our results indicated preprocedural fasting blood glucose >6.11 mmol/L and LDL-C levels ≥130 mg/dL may be useful predictors for PCI-related PMI. The study may provide a detailed data on the predictors of PCI-related PMI.