Impact of impaired glucose metabolism on responses to a psychophysical stressor: modulation by ketamine

Melanson, Brett; Lapointe, Thomas; Leri, Francesco

doi:10.1007/s00213-020-05748-w

Cited by 3 publications

(17 citation statements)

References 89 publications

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“…The forced swimming stress protocol used in the current study has been previously described by Melanson et al (2021) . Briefly, FSS was conducted in four transparent Plexiglass cylinders in a dimly lit room, and each cylinder was filled with tap water (23 ± 1 °C) to a depth of 40 cm.…”

Section: Methodsmentioning

confidence: 99%

“…Ketamine hydrochloride (Narketan; 100 mg/ml) was diluted with 0.9% saline (wt/vol) and injected intraperitoneally (10 or 20 mg/kg, IP) at a volume of 1 ml/kg. Doses for ketamine were chosen based on their ability to reverse stress-induced immobility in the rat forced swim test ( Carrier and Kabbaj, 2013 , Zhang et al, 2016 ) and their prophylactic effects against stress in rodents ( Amat et al, 2016 , Melanson et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

“…Interestingly, hypoglycemia negatively impacts mood ( Horman et al, 2018 ) and hedonic tone ( Gold et al, 1995 ) in several species, and can interact with other stressors to enhance their effects on behavior and physiology ( Deak et al, 2005 , Remus et al, 2015 ). For example, Melanson et al (2021) recently found that hypoglycemia induced by the glycolytic inhibitor, 2-deoxy- D -glucose (2-DG), interacted with forced swimming stress (FSS)—a psychophysical stressor ( Balkan et al, 2012 ; Imbe and Kimura, 2015 )—to amplify depressive-like behavioral responses in rats.…”

Section: Introductionmentioning

confidence: 99%

“…Given the high prevalence of metabolic and mood disorders ( Nouwen et al, 2019 ) and their significant burden of disease in North America ( World Health Organization, 2016 , World Health Organization, 2017 ), it is important to investigate pharmacological tools that may have clinical utility. Therefore, the current study investigated whether the glutamate N -methyl- D -aspartate (NMDA) receptor antagonist, ketamine, can modulate the interaction between hypoglycemia induced by 2-DG ( Melanson et al, 2021 ) and psychophysical stress induced by FSS ( Balkan et al, 2012 ) on serum levels of CORT and TNF-α. Typically, ketamine is used to induce anesthesia in surgical settings ( Gao et al, 2016 ), but recent clinical studies have also demonstrated its utility as a rapid-acting antidepressant drug ( Niciu et al, 2018 , Phillips et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…As well, pre-treating rodents with ketamine induces prophylaxis against future stressors ( Amat et al, 2016 , Brachman et al, 2016 ); and, lowers blood ( Gonçalves et al, 2021 , Zhan et al, 2020 ) and central ( Zhang et al, 2016 ) levels of pro-inflammatory cytokines ( Mastrodonato et al, 2020 , Walker et al, 2015 ). Finally, ketamine also reverses depressive-like behaviors induced by hypoglycemic and psychophysical stressors ( Melanson et al, 2021 ). In the current study, it was found that interacting hypoglycemic and psychophysical stress amplified CORT and TNF-α responses well after exposure to the combined stressors, and that pre-treatment with ketamine attenuated these effects.…”

Section: Introductionmentioning

confidence: 99%

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Effect of ketamine on the physiological responses to combined hypoglycemic and psychophysical stress

Melanson

Leri

2021

IBRO Neuroscience Reports

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There is evidence that hypoglycemic stress can interact with other stressors, and that ketamine can mitigate the impact of these stressors on behavior and physiology. The current study in male Sprague-Dawley rats investigated whether pre-treatment with 0, 10, or 20 mg/kg ketamine could modulate the interaction between hypoglycemia induced by 0 or 300 mg/kg 2-deoxy- D -glucose (2-DG) and the psychophysical stress of forced swimming (FSS; 6 sessions, 10 min/session) on serum concentrations of corticosterone (CORT) and the pro-inflammatory cytokine, tumor necrosis factor (TNF)-α. It was found that 2-DG enhanced the CORT response to an initial session of FSS, and this effect dissipated after multiple sessions. More importantly, animals displayed significantly higher levels of CORT and lower levels of TNF-α in response to a drug-free test swim conducted 1 week after exposure to the combined stressors, and these responses were not observed in rats that were pre-treated with ketamine. Overall, these findings indicate that ketamine has the potential to reduce the negative impact of interacting stressors on the biological reactivity of the hypothalamic-pituitary-adrenal axis and the immune system.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of ketamine on the physiological responses to combined hypoglycemic and psychophysical stress

Melanson

Leri

2021

IBRO Neuroscience Reports

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Evidence of hypoglycemic anhedonia and modulation by bupropion in rats

Horman

Ayoub

Leri

2021

Pharmacology Biochemistry and Behavior

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Conditioned anti-immobility by ketamine: A comparison to escitalopram and bupropion.

Melanson¹,

Wolter²,

Leatham³

et al. 2023

Experimental and Clinical Psychopharmacology

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This study was designed to explore the clinical belief that “set and setting” play an important role in favorable responses to psychedelic agents such as ketamine (KET). In fact, there is evidence in animals that the antidepressant effect of this drug may involve drug–environment interactions in which a context paired with its effects acquires the ability to influence behavior. Therefore, it was investigated in male Sprague–Dawley rats whether exposure to a context paired with the effects of KET, or with the effects of the common antidepressant medications bupropion (BUP) and escitalopram (ESC), could produce an antidepressant-like conditioned response. In Experiment 1, subjects received saline in a vehicle-paired context (denoted as CS−), and 0, 10, or 20 mg/kg KET, 10 mg/kg ESC, or 10 mg/kg BUP in a drug-paired context (denoted as CS+), on 10 alternating days (5 pairings with each context). The rats were then exposed drug free to the CS− and CS+ prior to the assessment of immobility in the forced-swimming test. Experiment 2 assessed approach/avoidance responses induced by the CS− and CS+ in a place-conditioning test. It was found that exposure to the KET CS+ significantly reduced immobility without affecting general locomotor activity in comparison to the SAL CS+ and the BUP CS+, but not the ESC CS+. Moreover, no group differences were observed in the place-conditioning test, indicating that the anti-immobility effect of the KET CS+ was likely not influenced by a conditioned incentive or aversive state. Together, these data suggest that a KET-paired context can elicit a conditioned antidepressant-like response, which may be a mechanism involved in its sustained antidepressant clinical action.

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Impact of impaired glucose metabolism on responses to a psychophysical stressor: modulation by ketamine

Cited by 3 publications

References 89 publications

Effect of ketamine on the physiological responses to combined hypoglycemic and psychophysical stress

Effect of ketamine on the physiological responses to combined hypoglycemic and psychophysical stress

Evidence of hypoglycemic anhedonia and modulation by bupropion in rats

Conditioned anti-immobility by ketamine: A comparison to escitalopram and bupropion.

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