“…In rodents, KET produces an anti-immobility effect in the forced-swimming test (Gigliucci et al, 2013; Melanson et al, 2021), a valid test of antidepressant efficacy of drugs (Porsolt et al, 1977, 1978). The behavioral effects may be related to KET’s diverse range of neuropharmacological actions (Amat et al, 2016; Cadeddu et al, 2016; Camargo et al, 2020; Donegan & Lodge, 2017; Fraga et al, 2021; Garcia et al, 2009; Gigliucci et al, 2013; Khakpai et al, 2019; Mastrodonato et al, 2020; Melanson & Leri, 2021; Wang et al, 2017; Yang et al, 2020; Zhang et al, 2016) and/or its protective effects against stress-induced changes in dendritic branching (Fraga et al, 2021) and dendritic spine formation (Moda-Sava et al, 2019; Ng et al, 2018).…”