Impact of IgE-Mediated Hypersensitivity on Nasal Mucociliary Clearance

Kirtsreesakul, Virat; Somjareonwattana, Pornpanitan; Ruttanaphol, Suwalee

doi:10.1001/archoto.2010.131

Cited by 8 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A significant positive correlation has been observed between MCT and the magnitude of the skin prick allergen reactivity to some common allergens [12]. However, no such relationship was found in the present study, even though MCT correlated positively with the serum concentration of specific IgEs to common allergens, but not to other allergens.…”

Section: Discussioncontrasting

confidence: 87%

“…In addition, MCT correlates well with illness duration [5], and a positive correlation has been found between MCT and the intensity of the wheal and flare reaction to house dust mites, cockroaches, and grass. [12]. In contrast, no significant differences in MCT were found between healthy subjects and AR or asthmatic patients in a study of a large group of children aged 11–14 years [13].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of Allergic Rhinitis on Nasal Mucociliary Clearance Time in Children

Mikolajczyk

Janukowicz

Majewska

et al. 2019

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Mucociliary clearance is one of the most important protective functions of the airway. Previous studies, checking the influence of allergic rhinitis (AR) on mucociliary clearance time (MCT), were made on small patient groups and brought contradictive results. Objectives: The aim of the study is to confirm whether AR in children influences MCT. Methods: The examined group consisted of 842 AR children. A total of 96 children with no history of allergy rhinitis served as a comparative group. All patients underwent saccharin and skin prick tests and tests for blood eosinophilia, nasal eosinophilia, vitamin D3 serum concentration, total and specific IgE serum concentration. Results: Nasal MCT was significantly longer in AR patients (mean ± SD: 10.5 ± 5.65 min) compared to controls (mean ± SD: 7.25 ± 4.3 min). Percentage of eosinophils in nasal smears in patients was significantly higher compared to controls and a weak, but significant positive correlation was observed between the percentage and MCT (r > 0.10, p < 0.008). Patients with intermittent and persistent moderate/ severe AR had significantly longer MCT and higher eosinophilia in nasal smears compared both to patients with intermittent and persistent mild RA and controls. No correlation was observed between MCT and: participant’s age, total serum IgE, vitamin D3 serum concentration, absolute number or percentage of eosinophils in blood, prick test results or duration of illness. Conclusions: AR affects the mucociliary clearance in children, and its deterioration is related to more severe rhinitis with higher intensity of local nasal inflammation, reflected in nasal smear eosinophilia.

show abstract

Section: Discussioncontrasting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Impact of Allergic Rhinitis on Nasal Mucociliary Clearance Time in Children

Mikolajczyk

Janukowicz

Majewska

et al. 2019

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…Atopic patients scored higher on VAS and complained of lower QoL. Recently, Kirtsreesakul et al 37 have described an increase in mucociliary clearance time in patients with allergic rhinitis compared with patients with nonallergic rhinitis who also had higher total nasal symptom scores and lower peak expiratory flow indices. This could explain the higher score in VAS and the lower score on QoL scales.…”

Section: Discussionmentioning

confidence: 98%

Aeroallergen Sensitization Influences Quality of Life and Comorbidities in Patients with Nasal Polyposis

Dávila

Rondón

Navarro

et al. 2012

Am J Rhinol�Allergy

View full text Add to dashboard Cite

show abstract

“…21 Individuals with allergic rhinitis confirmed by skin prick testing also have significant prolongation of mucociliary clearance time. 22 In these patients, the size of the largest allergic wheal correlates well with stunting of mucociliary clearance. Viral illnesses including influenza A and respiratory syncytial virus, in both healthy and allergic patients, prolong nasal mucociliary clearance times.…”

Section: Discussionmentioning

confidence: 96%

“…In addition, middle ear mucociliary clearance time is prolonged in animal models exposed to simulated gastric juices 21 . Individuals with allergic rhinitis confirmed by skin prick testing also have significant prolongation of mucociliary clearance time 22 . In these patients, the size of the largest allergic wheal correlates well with stunting of mucociliary clearance.…”

Section: Discussionmentioning

confidence: 99%