Impact of hypoxic tumor microenvironment and tumor cell plasticity on the expression of immune checkpoints

Lequeux, Audrey; Noman, Muhammad Zaeem; Xiao, Malina; Sauvage, Delphine; Moer, Kris Van; Viry, Elodie; Bocci, Irene Adelaide; Hasmim, Meriem; Bosseler, Manon; Berchem, Guy; Janji, Bassam

doi:10.1016/j.canlet.2019.05.021

Cited by 87 publications

(64 citation statements)

References 65 publications

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“…Hypoxia and the accompanying angiogenesis-promoting angiopoietins recruit monocytes expressing the cognate TIE2 receptor to tumors, where these myeloid precursors preferentially migrate to the hypoxic areas and differentiate into TAMs [ 34 , 35 , 36 ]. Accordingly, hypoxia is an important regulator of TAM biology [ 37 ]. PD-L1 expression in myeloid cells is upregulated directly by the hypoxia-inducible factor (HIF)-1α that binds to the PD-L1 promoter to induce PD-L1 transcription [ 38 ].…”

Section: Pd-l1 Expression On Non-tumor Cellsmentioning

confidence: 99%

Spatial and Temporal Changes in PD-L1 Expression in Cancer: The Role of Genetic Drivers, Tumor Microenvironment and Resistance to Therapy

Shklovskaya

Rizos

2020

IJMS

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Immunotherapies blocking immune inhibitory receptors programmed cell death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) on T-cells have dramatically improved patient outcomes in a range of advanced cancers. However, the lack of response, and the development of resistance remain major obstacles to long-term improvements in patient outcomes. There is significant interest in the clinical use of biomarkers to improve patient selection, and the expression of PD-1 ligand 1 (PD-L1) is often reported as a potential biomarker of response. However, accumulating evidence suggests that the predictive value of PD-L1 expression in tumor biopsies is relatively low due, in part, to its complex biology. In this review, we discuss the biological consequences of PD-L1 expression by various cell types within the tumor microenvironment, and the complex mechanisms that regulate PD-L1 expression at the genomic, transcriptomic and proteomic levels.

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Section: Pd-l1 Expression On Non-tumor Cellsmentioning

confidence: 99%

Spatial and Temporal Changes in PD-L1 Expression in Cancer: The Role of Genetic Drivers, Tumor Microenvironment and Resistance to Therapy

Shklovskaya

Rizos

2020

IJMS

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“…Hypoxia activates a series of pro-angiogenic factors through the aberrant expression of HIF-1α such that tumors transition to the angiogenesis phase (15,16). Studies have identified numerous signaling molecules which participate in the regulation of tumor angiogenesis (17,18).…”

Section: Discussionmentioning

confidence: 99%

Tanshinone IIA reduces secretion of pro‑angiogenic factors and inhibits angiogenesis in human colorectal cancer

et al. 2020

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Tumor angiogenesis is an important factor which precipitates recurrence and metastasis of colorectal cancer (CRC). Angiogenesis is also a significant feature which accompanies invasion and metastasis of CRC. Tumor hypoxia activates hypoxia inducible factor (HIF), which promotes angiogenesis in CRC. HIF significantly promotes cell proliferation and angiogenesis in CRC, facilitating invasion and metastasis. Tanshinone IIA (Tan IIA) has been revealed to effectively inhibit angiogenesis in CRC, although the underlying mechanism remains to be determined. The aim of the present study was to determine the effects of HIF-1α on hypoxia induced angiogenesis in CRC cells, the effects of Tan IIA on the expression of pro-angiogenic factors in CRC cells, and on human umbilical vein endothelial cell (HUVEC) tube formation in normal and hypoxic conditions. The results of the present study revealed that Tan IIA not only decreased HIF-1α expression and inhibited the secretion level of vascular endothelial growth factor and basic fibroblast growth factor, but also efficiently decreased proliferation, tube formation and metastasis of HUVECs. The results highlight the potential of Tan IIA-mediated targeting of HIF-1α as a potential therapeutic option for treatment of patients with CRC.

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“…The physical and chemical composition of the microenvironment such as acidic pH, low oxygen and nutrient availability, rigidity and porosity of the ECM can also play an important role in regulating the cancer stem cell behavior (Hjelmeland et al, 2011;Nallanthighal et al, 2019;Prager et al, 2019). A classic example would be hypoxia which is a hallmark of tumor progression in solid tumors and is associated with metastasis, therapeutic resistance and poor survival (Lequeux et al, 2019). A hypoxic microenvironment is known to regulate various aspects of malignant progression including cellular plasticity.…”

Section: The Effect Of the Tumor Microenvironment On Csc Plasticitymentioning

confidence: 99%

Cancer Stem Cell Plasticity – A Deadly Deal

Thankamony

Saxena

Murali

et al. 2020

Front. Mol. Biosci.

122

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Impact of hypoxic tumor microenvironment and tumor cell plasticity on the expression of immune checkpoints

Cited by 87 publications

References 65 publications

Spatial and Temporal Changes in PD-L1 Expression in Cancer: The Role of Genetic Drivers, Tumor Microenvironment and Resistance to Therapy

Spatial and Temporal Changes in PD-L1 Expression in Cancer: The Role of Genetic Drivers, Tumor Microenvironment and Resistance to Therapy

Tanshinone IIA reduces secretion of pro‑angiogenic factors and inhibits angiogenesis in human colorectal cancer

Cancer Stem Cell Plasticity – A Deadly Deal

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