Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery

Broglie, Martina A.; Stoeckli, Sandro J.; Sauter, Rafael; Pelletier, Philippe; Reinhard, Antoine; Leval, Laurence de; Huber, Gerhard; Pézier, Thomas F.; Soltermann, Alex; Giger, Roland; Arnold, A.; Dettmer, Matthias S.; Arnoux, André; Müller, Martin; Spreitzer, Stefan; Lang, Florian; Lutchmaya, Mathieu; Stauffer, Edouard; Espeli, Vittoria; Martucci, Francesco; Bongiovanni, Massimo; Foerbs, Diana; Jochum, Wolfram

doi:10.1002/hed.24865

Cited by 15 publications

(13 citation statements)

References 43 publications

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“…Similar to nonsurgical therapies, primary surgery demonstrates a superior outcome in HPV+ OPSCC compared to its HPV− counterpart . Although no currently established single standard for the treatment of OPSCC exists, there are numerous ongoing trials about treatment deintensification in HPV+ OPSCC and comparison of surgery and radiotherapy in terms of functional outcome (EORTC Best‐of trial NCT02984410), for which an accurate staging plays a key role for risk stratification.…”

Section: Discussionmentioning

confidence: 99%

“…All patients were treated with primary surgery with or without adjuvant treatment based on the presence of pathological risk factors. Details of patient characteristics, diagnostic, and treatment procedures were published in a previous paper . To optimize the diagnostic accuracy for HPV status, both p16 and HPV DNA positivity was sought as reported in the literature .…”

Section: Methodsmentioning

confidence: 99%

“…Details of patient characteristics, diagnostic, and treatment procedures were published in a previous paper. 4 To optimize the diagnostic accuracy for HPV status, both p16 and HPV DNA positivity was sought as reported in the literature. 13,22 A tumor was defined as HPV+ only if immunohistochemical p16 overexpression and HPV high risk type DNA by PCR were detected.…”

Section: Methodsmentioning

confidence: 99%

“…HPV− counterpart. 3,4,[28][29][30][31][32][33] Although no currently established single standard for the treatment of OPSCC exists, there are numerous ongoing trials about treatment deintensification in HPV+ OPSCC 34 and comparison of surgery and radiotherapy in terms of functional outcome (EORTC Bestof trial NCT02984410), for which an accurate staging plays a key role for risk stratification. As already mentioned, the increasing academic interest in HPV+ OPSCC and diminishing interest in HPV− OPSCC can only be partially justified with the change in epidemiology mainly in the developed world.…”

Section: Recurrence-free Survivalmentioning

confidence: 99%

“…Human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC) is known to have a better prognosis compared to its smoking and alcohol associated counterpart . This prominent difference was shown in multiple series treated either with primary surgery or primary (chemo)radiotherapy ((C)RT) . In 2010, Ang et al proposed a new staging system based on a recursive partitioning analysis done on a prospective randomized Radiation Therapy Oncology Group (RTOG) 0129 trial population with specific eligibility criteria .…”

Section: Introductionmentioning

confidence: 99%

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Comparison of contemporary staging systems for oropharynx cancer in a surgically treated multi‐institutional cohort

et al. 2018

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Background Between the publication of the Union of International Cancer Control staging system (UICC) 7th and 8th editions, other staging algorithms for oropharyngeal squamous cell carcinoma (OPSCC) were proposed from Radiation Therapy Oncology Group (RTOG), MD Anderson Cancer Center (MDACC), and Yale University. Methods With C‐statistics, the above‐mentioned five staging algorithms were compared for overall and relapse‐free survival endpoints in a multi‐institutional cohort of OPSCC cases (n = 338) treated with primary surgery. Results Pathological UICC 8th ed yielded the highest C‐indexes in the entire cohort and in the HPV− subset, whereas MDACC was superior for HPV+ OPSCC. RTOG was the simplest and holistic algorithm with a noninferior discriminatory power. Conclusion UICC 8th ed, MDACC, and RTOG offer moderate and comparable efficacy for staging in this OPSCC patient cohort undergoing surgical treatment. Notable discrepancy between clinical and pathological UICC 8th ed algorithms poses potential concerns in diagnosis, treatment, research, and data management.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Recurrence-free Survivalmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of contemporary staging systems for oropharynx cancer in a surgically treated multi‐institutional cohort

et al. 2018

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Head and Neck Cancers

Beyzadeoğlu

Özyiğit

Ebruli

2022

Basic Radiation Oncology

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SUVmax for predicting regional control in oropharyngeal cancer

Deprez

Morand

Thüring

et al. 2021

Eur Arch Otorhinolaryngol

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Purpose To investigate the predictive value of pretherapeutic metabolic tumor imaging using 18-fluorodeoxyglucose positron emission tomography (FDG-PET) for regional response in oropharyngeal cancer patients undergoing primary (chemo) radiation. Methods Retrospective analysis of oropharyngeal cancer patients treated with primary (chemo)radiation at the University Hospital Zurich from 2010 to 2019 with available FDG-PET. The SUV max of the largest lymph node metastases was recorded. Regional response was assessed using posttherapeutic FDG-PET at 12 weeks and regional recurrence-free survival. Results 95 patients with a mean age of 68.5 years (SD 10.3) were included. The median pretherapeutic nodal SUV max was 8.3 (interquartile range 4.4-13.3). A pretherapeutic nodal SUV max above 6 significantly predicted poorer regional recurrencefree survival (log-rank test, P = 0.009) in univariate analysis. However, in multivariate analysis SUV max above 6 was not significant in predicting regional recurrence-free survival (Cox regression P = 0.189). Clinical N category showed a trend in which a more severe stage had a poorer regional survival (Cox regression P = 0.073). ConclusionThe SUV max of the largest lymph node metastasis seems to play a role in predicting regional response in oropharyngeal cancer patients, after stratifying for N category. More research is needed to investigate whether highly metabolically active disease is less likely to respond to chemoradiation. KeywordsFluorodeoxyglucose F18 • Papillomavirus infections • Squamous cell carcinoma of head and neck • Positron emission tomography computed tomography • Lymphatic metastasis

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Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery

Abstract: Nonsmokers with HPV-positive oropharyngeal SCC have a better prognosis than smokers with HPV-positive oropharyngeal SCC and also than patients with HPV-negative tumors when treated by surgery alone.

Cited by 15 publications

References 43 publications

Comparison of contemporary staging systems for oropharynx cancer in a surgically treated multi‐institutional cohort

Comparison of contemporary staging systems for oropharynx cancer in a surgically treated multi‐institutional cohort

Head and Neck Cancers

SUVmax for predicting regional control in oropharyngeal cancer

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