Impact of Human Leukocyte Antigen Molecules E, F, and G on the Outcome of Transplantation

Pabón, Maria; Navarro, Cristian Eduardo; Osorio, Juan C.; Gómez, Natalia; Moreno, Julianna; Donado, Alicia; Pérez, Hernando; Lozano, E.

doi:10.1016/j.transproceed.2014.07.010

Cited by 16 publications

(20 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Population studies are important for evolutionary and anthropological studies. In addition, these data may improve donor‐recipient matching, as an increasing number of studies show that HLA genes other than the most studied HLA‐A , ‐B , ‐C , ‐DQB1 , and ‐DRB1 also impact hematopoietic stem cell and organ transplantation . Our results reinforce allelic and haplotypic similarities between the population from Curitiba and European populations, which corroborates previous studies that analyzed Euro‐descendants from Southern Brazil …”

Section: Discussionsupporting

confidence: 90%

High‐resolution characterization of 12 classical and non‐classical HLA loci in Southern Brazilians

Castro

Issler

Gelmini

et al. 2019

HLA

View full text Add to dashboard Cite

The human leukocyte antigen (HLA) are the most polymorphic genes in the human genome. Because of their importance for antigen recognition, HLA molecules play a central role in host defense and graft rejection upon transplantation. The aim of this study was to characterize allelic diversity of the classical HLA genes HLA‐A, ‐B, ‐C, ‐DRA, ‐DRB1, ‐DQA1, ‐DQB1, ‐DPA1, ‐DPB1, and the non‐classical class I genes HLA‐E, ‐F and ‐G at high‐resolution for a population of predominantly European ancestry from Curitiba, Brazil. Genotyping of 108 individuals was performed by next‐generation sequencing on the MiSeq platform and also by Sanger sequencing. The genotype distributions of all loci were in accordance with Hardy‐Weinberg equilibrium (P > 0.05) and a total of 202 HLA variants at second field resolution were observed for the 12 loci. The strongest linkage disequilibrium (r2 = 1.0, P < 10−5) was observed for the following pairs of alleles: HLA‐B*42:01:01 ~ HLA‐DRB1*03:02:01; HLA‐B*14:02:01 ~ HLA‐C*08:02:01; B*42:01:01 ~ HLA‐C*17:01:01; HLA‐DRB1*03:01:01 ~ HLA‐DQB1*02:01:01 ~ DRB1*03:01:01 ~ HLA‐DQB1*02:01:01; DRB1*13:01:01~ HLA‐DQB1*06:03:01 and HLA‐DRB1*09:01:02 ~ HLA‐DQA1*03:02. This is the first study to characterize all 12 HLA genes at high resolution in a single population. On the basis of the allelic frequencies of worldwide populations and principal component analysis, we confirmed the similarity of the study population to European and other Euro‐descendant populations.

show abstract

Section: Discussionsupporting

confidence: 90%

High‐resolution characterization of 12 classical and non‐classical HLA loci in Southern Brazilians

Castro

Issler

Gelmini

et al. 2019

HLA

View full text Add to dashboard Cite

show abstract

“…Unlike HLA-Ia, it has an intracytoplasmic domain [47]. Although HLA-F associates with β2m [48], no information is available on peptide presentation.…”

Section: Hla-fmentioning

confidence: 99%

“…It is interesting that HLA-E mismatches were observed in patients with matched HLA-Ia [59][60][61]. Paradoxically, the immunomodulatory mechanisms mediated by HLA-Ib can be expected to play a role in promoting graft acceptance [47,62], particularly in patients without viremia. This aspect of immunomodulation by HLA-Ib may clarify the variability observed in the duration of graft survival in transplants with HLA-Ia and -II matches and in mismatched ones when the time between DSA appearance and graft rejection was substantial [12].…”

Section: Non-classical Hla-ib and Transplantation Outcomementioning

confidence: 99%

“…Although, HLA-Ib molecules are oligomorphic, they can induce in transplant patients a cellular and/or humoral immunological response directed against their polymorphic residues; and, like minor histocompatibility antigens, they can affect allograft survival [12,47]. Specific genotypes of HLA-E or HLA-G are associated, respectively, with the protein expression on the cell surface and the release of the soluble form in circulation.…”

Section: Hla-ib: Role In Histocompatibilitymentioning

confidence: 99%

“…Most often, it is agreed that higher levels of HLA-Ib expression is associated with better allograft survival outcome [47,62], but some exceptions exist, such as in BMT, where higher levels of HLA-G expression is associated with higher risk of acute graft-versus-host disease (GvHD) [71]. Since heart, liver, kidney and lung allografts express HLA-Ib on their cell surface [47,62,73], even if the expression of HLA-Ib is low compared with that of HLA-Ia, both cell-surface expression and release in circulation of HLA-Ib are capable of affecting transplantation outcome. Selected patients with a high level of HLA-Ib expression, based on HLA-Ib genotypes, could benefit from lower immunosuppressive protocols while others could benefit from alternate therapeutic strategies.…”

Section: Hla-ib: Role In Histocompatibilitymentioning

confidence: 99%

See 2 more Smart Citations

Immunobiology of HLA Class-Ib Molecules in Transplantation

Jucaud¹

2015

SOJI

View full text Add to dashboard Cite

Immunological biomarkers of tolerance in human kidney transplantation: An updated literature review

Mirzakhani

Shahbazi

Oliaei

et al. 2018

Journal Cellular Physiology

View full text Add to dashboard Cite

The half-life of transplanted kidneys is <10 years. Acute or chronic rejections have a negative impact on transplant outcome. Therefore, achieving to allograft tolerance for improving long-term transplant outcome is a desirable goal of transplantation field. In contrast, there are evidence that distinct immunological characteristics lead to tolerance in some transplant recipients. In contrast, the main reason for allograft loss is immunological responses. Various immune cells including T cells, B cells, dendritic cells, macrophages, natural killer, and myeloid-derived suppressor cells damage graft tissue and, thereby, graft loss happens. Therefore, being armed with the comprehensive knowledge about either preimmunological or postimmunological characteristics of renal transplant patients may help us to achieve an operational tolerance. In the present study, we are going to review and discuss immunological characteristics of renal transplant recipients with rejection and compare them with tolerant subjects.

show abstract

Impact of Human Leukocyte Antigen Molecules E, F, and G on the Outcome of Transplantation

Cited by 16 publications

References 51 publications

High‐resolution characterization of 12 classical and non‐classical HLA loci in Southern Brazilians

High‐resolution characterization of 12 classical and non‐classical HLA loci in Southern Brazilians

Immunobiology of HLA Class-Ib Molecules in Transplantation

Immunological biomarkers of tolerance in human kidney transplantation: An updated literature review

Contact Info

Product

Resources

About