Impact of hormones on the regulation of cerebral vascular tone

Krause, Diana N.; Geary, Greg G.; McNeill, Anne Marie; Ospina, Jose A.; Duckles, Sue Piper

doi:10.1016/s0531-5131(02)00211-x

Cited by 4 publications

(5 citation statements)

References 14 publications

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“…Circulating androgenic and estrogenic steroids moderate the neuroimmune network’s responses via direct and indirect means ( Dantzer, 2017 ; Hampl et al., 2015 ; Robison et al., 2019 ). In general, estrogens tend to dilate cerebrovascular tone, increase cerebral flow, and facilitate immune-supporessing or anti-inflammatory responses in the brain and cerebrovasculature ( Brown et al., 2007 ; Gonzales et al., 2005 , 2008 ; Gottfried-Blackmore et al., 2008 ; Kipp et al., 2012 ; Krause et al., 2002 ; Ospina et al., 2003 , 2004 ; Sunday et al., 2006 ). Androgens tend to constrict vascular tone and enhance immune responses (i.e., pro-inflammatory effects).…”

Section: Discussionmentioning

confidence: 99%

“…The magnitude of regional and global BBB vulnerability to systemic immune events is influenced by age-related sex differences in circulating gonadal steroid hormones ( Abi-Ghanem et al., 2020 ; Duckles and Krause, 2007 ; Erdö et al., 2016 ; Erickson and Banks, 2019 ; Krause et al., 2006 ). Although our understanding of the androgenic influences on the BBB is complicated by the natural conversion of androgens to estrogenic steroids in the body, androgens and progesterone appear to oppose the cerebrovascular effects of estrogens ( Abi-Ghanem et al., 2020 ; Krause et al., 2002 ; Ospina et al., 2003 ; Robison et al., 2019 ). Androgens and progesterone generally constrict cerebrovascular tone and exert pro-inflammatory effects, whereas estrogens tend to dilate vascular tone, increase cerebral flow, and show immune-suppressing or anti-inflammatory properties ( Gonzales et al., 2005 , 2008 ; Krause et al., 2002 ; Ospina et al., 2003 , 2004 ; Sunday et al., 2006 ).…”

Section: Introductionmentioning

confidence: 99%

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Sex-specific responses of the pubertal neuroimmune axis in CD-1 mice

Kolmogorova

Ah-Yen

Taylor

et al. 2021

Brain, Behavior, & Immunity - Health

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The mechanistic relationship between the sexually dimorphic neuroimmune system and the sex-specific outcomes of a pubertal immune challenge is unclear. Therefore, we examined sex differences in the progression of cytotoxic microglial responses and blood-brain barrier (BBB) disruption to a peripubertal lipopolysaccharide (LPS) treatment in brain regions relevant to stress responses and cognitive function. Six-week-old (i.e., stress-sensitive pubertal period) male and female CD-1 mice were treated with LPS (1.5 mg/kg body weight, ip ) or 0.9% saline (LPS-matched volume, ip ). Sex and treatment differences in microglial (Iba1 + ) and apoptotic neuronal (caspase-3 + /NeuN + ) and non-neuronal (caspase-3 + /NeuN − ) expression were examined in the hippocampus, medial prefrontal cortex (mPFC), and paraventricular nucleus 24 h (sickness), one week (symptomatic recovery) and four weeks (early adulthood) post-treatment ( n = 8/group). Microglial morphology was quantified with fractal analyses. Group differences in BBB permeability to 14 C-sucrose were examined 24 h (whole-brain, hippocampus, prefrontal cortex, hypothalamus, and cerebellum) and one week (whole-brain) post-treatment. The acute effects of pubertal LPS were specific to females (i.e., global BBB disruption, altered microglial expression and morphology in the mPFC and hippocampus, increased hippocampal apoptosis). The residual effects of pubertal LPS-induced sickness observed in microglia persisted into adulthood in a sex- and region-specific manner. In addition to highlighting these sex-specific responses of the pubertal neuroimmune system, we report baseline region-specific sex differences in microglia spanning puberty through adulthood. We propose that these sex differences in neuroimmune-neurovascular interactions during the stress-sensitive pubertal period create sex biases in stress-related disorders of brain and behaviour.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sex-specific responses of the pubertal neuroimmune axis in CD-1 mice

Kolmogorova

Ah-Yen

Taylor

et al. 2021

Brain, Behavior, & Immunity - Health

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“…The reasons for the reduction of ICP by estrogen after TBI include: reduction of brain edema and AQP4 expression (Soltani et al, 2016), increase in cerebral blood flow (Hurn et al, 1995), and prevention of BBB destruction after TBI. Furthermore, one could also refer to the increase in antioxidant activity (Sugioka et al, 1987), adjustment in the production of NO (Krause et al, 2002), stimulation of estrogen alpha receptors in catecholaminergic neurons of the nucleus tractus solitarius (Shughrue et al, 1997) followed by hypotension (Chan and Sawchenko, 1994), increased secretion of arginine vasopressin and oxytocin (Mecawi et al, 2011), and reduction of inflammatory cytokines (Soltani et al, 2016). In this study, a direct correlation was found between brain edema and the ICP level 24 h after injury ( p < 0.001, R = 0.5).…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies in our laboratory have shown that estrogen decreases ICP and neurologic outcome after TBI, in which both of its receptors are involved. Other mechanisms have also been proposed for the neuroprotective effects of estrogen after TBI, such as the inhibition of membrane lipid peroxidation (Roof et al, 1994), modulating aquaporin 4 (AQP4) expression (Soltani et al, 2016), matrix metalloproteinase inhibition (MMP9) (Walf et al, 2008), and the production of nitric oxide (NO) (Krause et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Candesartan Alone and Its Combination With Estrogen on Post-traumatic Brain Injury Outcomes in Female Rats

et al. 2019

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Aim: The aim of this study was to evaluate the effect of candesartan (angiotensin II type I receptor blocker) alone and its combination with estrogen on the changes in brain edema, intracranial pressure (ICP), and cerebral perfusion pressure (CPP) following diffuse traumatic brain injury (TBI) in female rats.Methods: TBI was induced in ovariectomized female rats using Marmarou's method. The treatment groups received low-dose (LC) and high-dose (HC) candesartan, estrogen (E2), a combination of estrogen vehicle and candesartan vehicle (oil + vehicle), or a combination of estrogen with low-dose (E2 + LC), or with high-dose (E2 + HC) candesartan. ICP and CPP were measured before and several times after TBI, and the brain water content (brain edema) was measured 24 h after TBI.Results: After the TBI, brain edema and ICP in the estrogen group were lower than in the vehicle and TBI groups. Brain edema and ICP in the HC group were lower than in the vehicle group after TBI. Although there was no significant difference in brain edema and ICP between the LC and vehicle groups, significant differences in these variables were observed when the E2 + LC and E2 + HC groups were compared with the oil + vehicle group after TBI. A significant increase in CPP was observed in the estrogen group 4 and 24 h post-TBI, while this increase was found in the HC and E2 + LC groups 24 h post-TBI.Conclusions: A low dose of candesartan did not exert a protective effect on TBI outcomes, but such an effect did appear after combination with estrogen. This finding suggests that interaction between low-dose candesartan and estrogen improves TBI-induced consequences.

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“…The study of precerebral and cerebral hemodynamics allows estimating the mechanisms of anatomic, myogenic, and metabolic reserves in cerebral blood flow regulation [24,25]. The literature provides the data on the effect of circulating hormones on cerebral blood flow regulation, in particular, on changes in the tone of brain vessels depending on the concentration of blood melatonin and estrogen/testosterone [26].…”

Section: Discussionmentioning

confidence: 99%

Analysis of muscle tone and strength and cerebral blood flow in kickboxers

Shevtsov

Сашенков

Шибкова

et al. 2019

PPS

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Purpose: the article deals with providing a characteristic of muscle and tone status as well as precerebral and cerebral hemodynamics in kickboxers. Materials: 102 athletes with the qualification from the Second-class Athlete to the Master of Sport voluntary participated in the study. The average age of athletes at the moment of the study was 20.90±0.50. The average sports experience of participants was equal to 4.15±2.77. The control group consisted of apparently healthy young males of the same age but not involved in sports activities (n=35). The indicators of muscle tone and strength and cerebral blood flow were studied with the help of Doppler ultrasound of the main arteries of the head, electroneuromyography, and transcranial Doppler. Results: the article provides the results of the study on the effect of muscle and tone disturbances in the spinal motion segment on the functional status of precerebral and cerebral blood flow. The disturbances in nerve conduction velocity in the symmetrical groups of trunk muscles are considered as the reason for muscle imbalance in 50% of athletes. The analysis of blood flow indicators in kickboxers with muscle imbalance revealed a typical increase in the tone of precerebral vessels and changes in the gradients of blood flow velocity in various segments of the carotid and vertebral arteries. The decrease of cerebral blood flow in athletes, in particular, the venous outflow of a dystonic nature, is the result of spasmodic and ischemic Doppler patterns against a decreased indicator of arteriovenous balance. Mild traumatic brain injuries should also be taken into account when speaking about the development of cerebrovascular dysfunction as a result of kickboxers’ sparring activities and competitions. Conclusions: Differentiated disturbances in sensory and motor conductivity result in the disturbance of afferentation and muscle imbalance intensity. Angiospasm and vascular ischemia determine the increase in the linear blood flow velocity in the carotid system and the decrease in the vessels of the vertebrobasilar system against the increase in resistivity indicators in the carotid basins and vertebrobasilar system in kickboxers. Correlation analysis revealed visceral motor correlations, which proved the influence of the functional status of the regional muscle system on cerebral hemodynamics. The analysis of tone and strength muscle characteristics and cerebral blood flow in kickboxers indicates the necessity of correcting muscle and tone asymmetry of the paravertebral area.

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Impact of hormones on the regulation of cerebral vascular tone

Cited by 4 publications

References 14 publications

Sex-specific responses of the pubertal neuroimmune axis in CD-1 mice

Sex-specific responses of the pubertal neuroimmune axis in CD-1 mice

The Effect of Candesartan Alone and Its Combination With Estrogen on Post-traumatic Brain Injury Outcomes in Female Rats

Analysis of muscle tone and strength and cerebral blood flow in kickboxers

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