Impact of HIV and Mycobacterium Tuberculosis
Co-Infections on Antioxidant Status in Nigeria

Nkechi, Osuji Faustina; Chinedu, Onyenekwe Charles; Ositadinma, Ifeanyichukwu Martin; Ebere, Ahaneku Joseph; Ezeani, M; Priscilla, Ezeugwunne Ifeoma

doi:10.3923/pjn.2013.496.504

Cited by 1 publication

(1 citation statement)

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“…HIV infection is associated with increased production of free radicals leading to OS through a number of mechanisms4. HIV infection is also associated with suppression of the anti-oxidant defense system5,6. M. tuberculosis (Mtb) is the leading opportunistic infection among HIV patients and is also associated with OS.…”

Section: Introductionmentioning

confidence: 99%

Effect of anti-retroviral therapy on oxidative stress in hospitalized HIV-infected adults with and without TB

Musisi¹,

Matovu²,

Bukenya³

et al. 2018

Afr H. Sci.

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BackgroundHIV infection and opportunistic infections cause oxidative stress (OS), which is associated with tissue damage. Anti-retroviral therapy (ART) is used to treat HIV and decrease the risk of opportunistic infections, but it is unclear whether ART reduces OS. Association of ART with OS was investigated.MethodsWe stratified a convenience sample of frozen serum or plasma from HIV-infected, ART-naïve (n=21); HIV-infected, ART-treated (n=14); HIV and PTB co-infected, ART-naïve (n=21); HIV and PTB co-infected, ART-treated (n=25) patients. Controls (n=21) were HIV-negative adults without TB symptoms. Concentration of OS markers namely: transaminases (ALT and AST), gamma glutamyl transpeptidase (GGT), albumin, total protein, malondialdehyde (MDA), vitamin C, and total anti-oxidant status (TAS) were determined.ResultsAST (p<0.001), GGT (p<0.001), total protein (p=0.001) and MDA (p<0.001) were higher in HIV patients compared to controls. Vitamin C (P<0.0001) and albumin (p<0.01) were lower in HIV-patients relative to controls. ART was only associated with higher albumin (p=0.001), higher GGT (p=0.02) and lower vitamin C (p=0.009). HIV and PTB co-infection was only significantly associated with higher GGT (p=0.01) and AST (p=0.03).ConclusionWe identified severe OS among HIV-patients. ART was associated with both increased and reduced markers of OS hence suggesting that ART may not attenuate OS.

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Section: Introductionmentioning

confidence: 99%