Impact of hepatic steatosis on viral kinetics and treatment outcome during antiviral treatment of chronic HCV infection

Westin, Johan; Lagging, Martin; Dhillon, Amar P.; Norkrans, Gunnar; Romero, Ana I.; Pawlotsky, Jean‐Michel; Zeuzem, Stefan; Schalm, S. W.; Verheij-Hart, Elke; Negro, Francesco; Missale, Gabriele; Neumann, Avidan U.; Hellstrand, Kristoffer

doi:10.1111/j.1365-2893.2006.00777.x

Cited by 71 publications

(53 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, theoretically, patients with a high fraction of HCV-infected hepatocytes will have high ε c and hence will have a poorer chance of achieving SVR. Interestingly, Pal et al [47] showed that advanced liver disease is associated with a higher fraction of HCV-infected hepatocytes and lower SVR rates (<29%) than for patients without liver disease [25,26,48,49].…”

Section: Critical Drug Efficacymentioning

confidence: 99%

See 1 more Smart Citation

Hepatitis C viral kinetics in special populations

Dahari

Layden‐Almer²,

Perelson³

et al. 2008

Curr hepatitis rep

View full text Add to dashboard Cite

Mathematical models of hepatitis C viral (HCV) kinetics provide a means of estimating the antiviral effectiveness of therapy, the rate of virion clearance and the rate of loss of HCV-infected cells. They have also proved useful in evaluating the extrahepatic contribution to HCV plasma viremia and they have suggested mechanisms of action for both interferon-α and ribavirin. Viral kinetic models can explain the observed HCV RNA profiles under treatment, e.g., flat partial response, biphasic and triphasic viral decay and viral rebound. Current therapy with (pegylated) interferon-α and ribavirin has a poorer success in patients having insulin resistance, hepatic fibrosis, African American ethnicity, HCV/HIV-coinfection, HCV genotype-1 and high baseline viral load. The use of mathematical modeling and statistical analysis of experimental data have been useful in understanding some of these treatment obstacles.

show abstract

Section: Critical Drug Efficacymentioning

confidence: 99%

“…• The presence of steatosis impairs the early reduction of viral load during treatment in patients infected with HCV [25].…”

Section: First-phase Hcv Rna Decline During Interferon-α Based Therapymentioning

confidence: 99%

Hepatitis C viral kinetics in special populations

Dahari

Layden‐Almer²,

Perelson³

et al. 2008

Curr hepatitis rep

View full text Add to dashboard Cite

show abstract

“…It has been shown in large clinical trials that steatosis impairs the response to antiviral therapy (65,66). The effect, however, is more pronounced in patients with the non-3a genotype (55,56), implicating IR as the mechanism that affects the response to IFN-α and suggesting that viral steatosis does not impair the response to treatment (67,68). It is worth noting that patients with CHC with virally induced steatosis do not have increased IR levels relative to patients without steatosis (69).…”

Section: Hepatic Steatosismentioning

confidence: 93%

The Impact of Host Factors on Management of Hepatitis C Virus

Khattab¹,

Eslam

2012

Hepat Mon

View full text Add to dashboard Cite

“…Westin et al (58) , in a European multicentric study, demonstrated that 88% of the genotype 3 patients obtained SVR, regardless of the high prevalence of steatosis and pretreatment viral load found in this group. In genotypes other than 3, a 56% SVR rate was found, and, in patients with steatosis, this rate was of 46%, whereas, in those without steatosis this rate was of 65%, demonstrating the impact of steatosis on SVR in these patients.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the sustained virological response in patients with chronic hepatitis C and liver steatosis

Piccoli

Mattos

Coral

et al. 2011

Arq. Gastroenterol.

View full text Add to dashboard Cite

-Context -Chronic hepatitis C as well as non-alcoholic fatty liver disease are recognized as the main cause of liver disease in Western countries. It is common to see the concomitance of the diseases and the influence of steatosis in the sustained virological response of patients with hepatitis C virus. Objective -Assess the sustained virological response in chronic hepatitis C patients according to the presence of liver steatosis. Methods -One hundred sixty patients with chronic hepatitis C were retrospectively evaluated. Demographic data such as gender, age, body mass index, presence of diabetes mellitus and systemic arterial hypertension, virus genotype and use of pegylated interferon were analyzed, as was the staging of fibrosis and the presence of steatosis at histology. Results -Most patients were male (57.5%), with a mean age of 48 ± 9.7 years. The most frequent genotype observed was 3 (56.9%) and, in the histological evaluation, steatosis was observed in 65% of the patients (104/160). Sustained virological response in patients with steatosis occurred in 38.5%, and in 32.1% in patients without steatosis (P = 0.54). When we analyzed possible factors associated with the presence of steatosis, only body mass index and systemic arterial hypertension revealed a significant association. When the factors that influenced sustained virological response were evaluated in a logistic regression, genotype and use of pegylated interferon proved to be independent factors associated to the response. Conclusion -In the evaluated patients the presence of liver steatosis did not influence the sustained virological response of patients with chronic hepatitis C treated with interferon and ribavirin.

show abstract

Impact of hepatic steatosis on viral kinetics and treatment outcome during antiviral treatment of chronic HCV infection

Cited by 71 publications

References 29 publications

Hepatitis C viral kinetics in special populations

Hepatitis C viral kinetics in special populations

The Impact of Host Factors on Management of Hepatitis C Virus

Analysis of the sustained virological response in patients with chronic hepatitis C and liver steatosis

Contact Info

Product

Resources

About