Impact of Helminth Infection during Pregnancy on Cognitive and Motor Functions of One-Year-Old Children

Mireku, Michael O.; Boivin, Michael J.; Davidson, Leslie L.; Ouédraogo, Smaïla; Koura, Kobto Ghislain; Alao, Maroufou Jules; Massougbodji, Achille; Cot, Michel; Bodeau-Livinec, Florence

doi:10.1371/journal.pntd.0003463

Cited by 50 publications

(59 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A flowchart of the follow-up of pregnant women and children has been published elsewhere. 20 Maternal baseline characteristics were similar between children not assessed and those assessed at age 1 year. 20 Mean maternal age (SD) at first ANC visit was 26.8 (5.6) years.…”

Section: Resultsmentioning

confidence: 82%

See 1 more Smart Citation

Prenatal Hemoglobin Levels and Early Cognitive and Motor Functions of One-Year-Old Children

et al. 2015

Self Cite

View full text Add to dashboard Cite

OBJECTIVE: To explore the relationship between prenatal hemoglobin (Hb) concentration and infant cognitive and motor functions.METHODS: Our prospective cohort study included 1-year-old children born to women enrolled at their first antenatal care (ANC) visit in Allada, Benin, before 29 weeks of pregnancy, within a trial comparing the efficacy of sulfadoxine-pyrimethamine and mefloquine. Hb concentrations of pregnant women were determined from venous blood samples collected at first and second ANC visits of at least 1-month interval and at delivery. Women were prescribed oral iron, folic acid, and anthelminthics after the first ANC visit. A total of 636 children (76.8% of eligible children) were assessed by trained research nurses for cognitive and motor functions by using the Mullen Scales of Early Learning. 3) at first ANC visit to 112.4 (14.1) at delivery. We observed a significant negative quadratic relationship between infant gross motor (GM) function and Hb concentration at first and second ANC visits. Thus, infant GM scores increased sharply with increasing maternal Hb concentration until 90 g/L where increasing GM was mild, and began to decline after 110 g/L.CONCLUSIONS: There appears to be an Hb concentration range that may be optimal for GM function of 1-year-old children. This may reflect the importance of physiologic hemodilution, which occurs after the second trimester until 34 weeks of gestation.WHAT'S KNOWN ON THIS SUBJECT: Studies on the consequences of abnormal prenatal hemoglobin (Hb) concentration have focused on maternal morbidities and adverse birth outcomes. To date, very little is known about the association between prenatal Hb concentration and infant cognitive and motor functions. WHAT THIS STUDY ADDS:There is an inverted U-shaped relationship between maternal Hb concentration and infant gross motor function. Hb concentration between 90 and 110 g/L appears to be optimal for early gross motor function of children.

show abstract

Section: Resultsmentioning

confidence: 82%

“…20 Maternal baseline characteristics were similar between children not assessed and those assessed at age 1 year. 20 Mean maternal age (SD) at first ANC visit was 26.8 (5.6) years. The prevalence of malaria was 16.0% at first ANC visit, declined to 3.7% at second ANC visit, and then increased to 10.6% at delivery.…”

Section: Resultsmentioning

confidence: 82%

Prenatal Hemoglobin Levels and Early Cognitive and Motor Functions of One-Year-Old Children

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…In children with malaria, deficits in fine motor skills were more pronounced in children with cerebral malaria than those with severe malarial anemia while another study found that helminth infection was associated with poor gross motor function (Bangarina et al, 2016; Mireku et al, 2015). …”

Section: General Comprehensive and Specific Neurodevelopment Tests (mentioning

confidence: 99%

Selecting measures for the neurodevelopmental assessment of children in low- and middle-income countries

Semrud‐Clikeman

Romero

Prado

et al. 2016

Child Neuropsychology

View full text Add to dashboard Cite

Diseases affecting millions of children in low and middle-income countries (LMIC), such as malnutrition, micronutrient deficiency, malaria, and HIV, can lead to adverse neurodevelopmental outcomes. Thus, a key health outcome in children is neurodevelopmental status. We reviewed the neurodevelopmental screening and testing measures most commonly utilized in LMIC, and created a matrix to help researchers and clinicians determine which measures may be most useful for various LMIC inquiries. The matrix was based on an internet literature review of 114 publications from January 1998 to May 2016 reporting the psychometric properties of instruments tested in LMIC children. Measures were classified as screening tests or more detailed tests that included both comprehensive batteries of general development and tests of specific domains. We have also had two experts as well as the authors review this paper for completeness. We provide an overview of tests used to date, including the benefits and drawbacks of each test, to provide researchers and developmental clinicians with a way to decide which tests may be best suited to their developmental assessment goals. Remarkable progress has been made in neurodevelopmental testing in children in LMIC over the past two decades but there remains a need for additional research in this area to develop new tests, better evaluate and adapt current tests, and assess test validity and reliability across cultures.

show abstract

“…Numerous studies document the effects of vertically acquired HIV infection in multiple areas of neurodevelopment in school age children including overall cognitive ability, 46,47 memory, perception, 48 motor function, 49, 50 executive function, 51 and language skills. 50, 52 Maternal helminth infection shows effects on children at 1 year of age that may well extend into early to middle childhood, 53 but these effects are so far unstudied. Findings like this highlight the need for longitudinal studies of the effects of maternal or congenital infections on child neurodevelopment across the age span.…”

Section: The Impact Of Inflammation On Neurodevelopment During Early mentioning

confidence: 99%

Neurodevelopment: The Impact of Nutrition and Inflammation During Early to Middle Childhood in Low-Resource Settings

2017

View full text Add to dashboard Cite

The early to middle childhood years are a critical period for child neurodevelopment. Nutritional deficiencies, infection and inflammation are major contributors to impaired child neurodevelopment in these years, particularly in low resource settings. This review identifies global research priorities relating to nutrition, infection, and inflammation in early to middle childhood neurodevelopment. Research priority areas identified include: 1) assessment of how nutrition, infection or inflammation in the pre-conception, prenatal and infancy periods (or interventions in these periods) affect function in early to middle childhood; 2) assessment of whether effects of nutritional interventions vary by poverty or inflammation; 3) determination of the feasibility of pre-school and school-based integrated nutritional interventions; 4) improved assessment of the epidemiology of infection- and inflammation-related neurodevelopmental impairment (NDI); 5) identification of mechanisms through which infection causes NDI; 6) identification of non-infectious causes of inflammation-related NDI and interventions for causes already identified (e.g, environmental factors); and 7) studies on the effects of interactions between nutritional, infectious and inflammatory factors on neurodevelopment in early to middle childhood. Areas of emerging importance which require further study include the effects of maternal Zika virus infection, childhood environmental enteropathy, and alterations in the child’s microbiome on neurodevelopment in early to middle childhood. Research in these key areas will be critical to the development of interventions to optimize the neurodevelopmental potential of children worldwide in the early to middle childhood years.

show abstract

Impact of Helminth Infection during Pregnancy on Cognitive and Motor Functions of One-Year-Old Children

Cited by 50 publications

References 35 publications

Prenatal Hemoglobin Levels and Early Cognitive and Motor Functions of One-Year-Old Children

Prenatal Hemoglobin Levels and Early Cognitive and Motor Functions of One-Year-Old Children

Selecting measures for the neurodevelopmental assessment of children in low- and middle-income countries

Neurodevelopment: The Impact of Nutrition and Inflammation During Early to Middle Childhood in Low-Resource Settings

Contact Info

Product

Resources

About