Prenatal Hemoglobin Levels and Early Cognitive and Motor Functions of One-Year-Old Children

Mireku, Michael O.; Davidson, Leslie L.; Koura, Kobto Ghislain; Ouédraogo, Smaïla; Boivin, Michael J.; Xiong, Xu; Accrombessi, Manfred; Massougbodji, Achille; Cot, Michel; Bodeau-Livinec, Florence

doi:10.1542/peds.2015-0491

Cited by 52 publications

(53 citation statements)

References 26 publications

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“…The relationship between prenatal Hb concentration and infant cognitive and motor development in our study population has already been reported in an earlier publication. 13 Considering the vulnerability of the fetus to prenatal insults and the essential role of iron in neurodevelopment, it is surprising that we found no association between prenatal ID and infant cognitive development. However, during pregnancy, the fetus has priority to iron supply over the pregnant woman's needs to ensure adequate iron stores within the first 6 months of life and 4…”

Section: Discussionmentioning

confidence: 73%

“…13 This article is therefore a secondary analysis of that data. The mothers had all been enrolled earlier in the Malaria in Pregnancy Preventive Alternative Drugs (MiPPAD) clinical trial (NCT00811421) that compared the efficacy of mefloquine and sulfadoxine pyrimethamine as intermittent preventive treatment of pregnant women (IPTp).…”

Section: Study Design and Populationmentioning

confidence: 99%

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Prenatal Iron Deficiency, Neonatal Ferritin, and Infant Cognitive Function

et al. 2016

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To investigate the impact of prenatal maternal iron deficiency (ID) on cord blood serum ferritin (CBSF) concentration and infant cognitive and motor development. METHODS:Our prospective cohort study included 636 mother-singleton child pairs from 828 eligible pregnant women who were enrolled during their first antenatal care (ANC) visit in Allada, Benin, into a clinical trial comparing the efficacy of mefloquine and sulfadoxinepyrimethamine. Venous blood samples of women were assessed for ferritin and hemoglobin concentrations at the first and second ANC visits (occurring at least 1-month apart) and at delivery. Women were prescribed daily iron and folic acid supplements throughout pregnancy. Hematologic examinations were repeated for cord blood at birth. At age 1 year, cognitive and motor functions of children were assessed by using the Mullen Scales of Early Learning. RESULTS:The prevalence of prenatal ID at first and second ANC visits, and at delivery was 30.5%, 34.0%, and 28.4%, respectively. CBSF concentrations were similar between ID and non-ID pregnant women. Neither prenatal ID nor CBSF concentration was associated with poor cognitive or gross motor function of children at age 1 year. CBSF concentrations were lower among mothers who had ID anemia (IDA) at delivery compared with non-IDA pregnant women (adjusted mean difference: -0.2 [95% confidence interval: -0.4 to -0.0]). CONCLUSIONS:In a malaria-endemic region, ID in pregnancy in the context of iron supplementation is neither associated with CBSF concentration nor with infant cognitive and motor development. Prenatal IDA around the time of delivery is associated with lower CBSF concentrations.

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Section: Discussionmentioning

confidence: 73%

Section: Study Design and Populationmentioning

confidence: 99%

Prenatal Iron Deficiency, Neonatal Ferritin, and Infant Cognitive Function

et al. 2016

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“…Accordingly, some previous studies have evidenced a relationship between suboptimal maternal diet in pregnancy and poorer mental and psychomotor development in offspring [5,6,[12][13][14][15][16]. More specifically, several studies have reported that iron deficiency (ID) in pregnancy may adversely influence brain development and be associated with infant and child behavioral problems and poorer cognitive development [5,6,13,[17][18][19][20][21]. More recently, it has been suggested that ID during pregnancy may not only have effects in early life [5,6,[21][22][23][24] but could also be related to long-term alterations in cognitive, behavior, and social development and poorer school performance during childhood and adolescence [3,12,[25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study

et al. 2019

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Early iron status plays an important role in prenatal neurodevelopment. Iron deficiency and high iron status have been related to alterations in child cognitive development; however, there are no data about iron intake during pregnancy with other environmental factors in relation to long term cognitive functioning of children. The aim of this study is to assess the relationship between maternal iron status and iron intake during pregnancy and child neuropsychological outcomes at 7 years of age. We used data from the INMA Cohort population-based study. Iron status during pregnancy was assessed according to serum ferritin levels, and iron intake was assessed with food frequency questionnaires. Working memory, attention, and executive function were assessed in children at 7 years old with the N-Back task, Attention Network Task, and the Trail Making Test, respectively. The results show that, after controlling for potential confounders, normal maternal serum ferritin levels (from 12 mg/L to 60 mg/L) and iron intake (from 14.5 mg/day to 30.0 mg/day), respectively, were related to better scores in working memory and executive functioning in offspring. Since these functions have been associated with better academic performance and adaptation to the environment, maintaining a good state of maternal iron from the beginning of pregnancy could be a valuable strategy for the community.

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“…This consequently increases the incidence of placenta previa and preterm placenta abruption. Mireku et al report a link between mothers who had anemia lower than 9.0 g/dl during pregnancy with a lower cognitive and motor development in one-year-old children [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Treatment of Anemia of Chronic Disease with True Iron Deficiency in Pregnancy

Benčaiová

Krafft

Zimmermann

et al. 2017

Journal of Pregnancy

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Objective We assess and compare the efficacy of anemia treatment in pregnant women with anemia of chronic disease with true iron deficiency and in women with iron deficiency anemia. Study Design Fifty patients with moderate anemia (hemoglobin 8.0–9.9 g/dl) and iron deficiency (ferritin < 15 μg/l) were treated in the Anemia Clinic at the Department of Obstetrics. Results All patients showed stimulation of erythropoiesis as evidenced by an increase in reticulocyte count at day eight of therapy and showed an increase in hemoglobin and hematocrit at the end of therapy (p < 0.001). The target hemoglobin (≥10.5 g/dl) was achieved in 45/50 women (90%). 12 patients showed anemia of chronic disease with true iron deficiency (12/50; 24%). Seven women (7/12; 59%) with anemia of chronic disease and iron deficiency responded well to anemia treatment. 50% of women with anemia of chronic disease and iron deficiency (3/6) responded well to intravenous iron, and 67% (4/6) responded well to the combination of intravenous iron and recombinant human erythropoietin. Conclusion Because of frequent true iron deficiency in pregnant women with anemia of chronic disease, anemia of chronic disease in pregnancy is often falsely diagnosed as iron deficiency anemia.

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Prenatal Hemoglobin Levels and Early Cognitive and Motor Functions of One-Year-Old Children

Cited by 52 publications

References 26 publications

Prenatal Iron Deficiency, Neonatal Ferritin, and Infant Cognitive Function

Prenatal Iron Deficiency, Neonatal Ferritin, and Infant Cognitive Function

Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study

Treatment of Anemia of Chronic Disease with True Iron Deficiency in Pregnancy

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