Impact of glycemic variability in patients with ST-elevated myocardial infarction

Tokue, Masahide; Iijima, Raisuke; Imamura, Takaaki; Niikura, Hiroki; Hayashi, Fumiyuki; Yazaki, Yoshio; Nagashima, Yoshinori; Yamazaki, Kenji; Ono, Tsuyoshi; Hara, Hidehiko; Nakamura, Masato; Sugi, Kaoru

doi:10.1016/j.ijcard.2015.03.365

Cited by 9 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although it has not yet been definitively confirmed as an independent risk factor for diabetes complications, many reports have shown that GV was associated with both micro- and macrovascular complications [ 6 ]. For exemple, high GV measured early after the onset of a first-episode of acute coronary syndrome is associated with a higher risk of major adverse cardiac and cerebrovascular events at 30 days [ 7 ]. All those data suggest a deleterious role of GV on cardiovascular diseases but the cellular and molecular mechanisms remain poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Glucose fluctuation promotes mitochondrial dysfunctions in the cardiomyocyte cell line HL-1

Mordel,

Fontaine,

Dupas

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Aims Glycemic variability has been suggested as a risk factor for diabetes complications but the precise deleterious mechanisms remain poorly understood. Since mitochondria are the main source of energy in heart and cardiovascular diseases remain the first cause of death in patients with diabetes, the aim of the study was to evaluate the impact of glucose swings on mitochondrial functions in the cardiomyocyte cell line HL-1. Methods HL-1 cells were exposed to low (LG, 2.8 mmol/l), normal (NG, 5.5 mmol/l), high (HG, 25 mmol/l) or intermittent high glucose (IHG, swing between low and high) every 2h during 12h (short-time treatment) or every 12h during 72h (long-time treatment). Anaerobic catabolism of glucose was evaluated by measuring glucose consumption and lactate production, oxidative phosphorylation was evaluated by polarography and ATP measurement, mitochondrial superoxide anions and the mitochondrial membrane potential (MMP) were analysed using fluorescent probes, and the protein oxidation was measured by oxyblot. Results IHG and HG increased glucose consumption and lactate production compared to LG and NG but without any difference between short- and long-time treatments. After 72h and unlike to LG, NG and HG, we didn’t observe any increase of the mitochondrial respiration in the presence of succinate upon IHG treatment. IHG, and to a lesser extent HG, promoted a time-dependent decrease of the mitochondrial membrane potential compared to LG and NG treatments. HG and IHG also increased superoxide anion production compared to LG and NG both at 12 and 72h but with a higher increase for IHG at 72h. At last, both HG and IHG stimulated protein oxidation at 72h compared to LG and NG treatments. Conclusions Our results demonstrated that exposure of HL-1 cells to glucose swings promoted time-dependent mitochondrial dysfunctions suggesting a deleterious effect of such condition in patients with diabetes that could contribute to diabetic cardiomyopathy.

show abstract

Section: Introductionmentioning

confidence: 99%

Glucose fluctuation promotes mitochondrial dysfunctions in the cardiomyocyte cell line HL-1

Mordel,

Fontaine,

Dupas

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Furthermore, hyperglycemia has also been linked to reperfusion injury [ 2 ]. According to previous studies, hyperglycemia imposes a higher mortality risk and complications during in-hospital stay [ 4 , 5 ], including larger myocardial infarct size and major adverse cardiovascular events (MACE) [ 1 , 3 , 5 ]. Diabetes mellitus (DM) is a key factor in causing several cardiovascular complications but patients with and without known diabetes mellitus, both are affected by hyperglycemia [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Diabetes mellitus (DM) is a key factor in causing several cardiovascular complications but patients with and without known diabetes mellitus, both are affected by hyperglycemia [ 3 , 4 ]. Currently, acute hyperglycemic state is labeled as ≥180 mg/dL at the time of admission [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Plasma random glucose levels at hospital admission predicting worse outcomes in STEMI patients undergoing PCI: A case series

Kirmani

Singh

Kumar

et al. 2022

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

Acute glycemic variability on admission predicts the prognosis in hospitalized patients with coronary artery disease: a meta-analysis

Lai

Yang

et al. 2019

Endocrine

View full text Add to dashboard Cite

Impact of glycemic variability in patients with ST-elevated myocardial infarction

Cited by 9 publications

References 8 publications

Glucose fluctuation promotes mitochondrial dysfunctions in the cardiomyocyte cell line HL-1

Glucose fluctuation promotes mitochondrial dysfunctions in the cardiomyocyte cell line HL-1

Plasma random glucose levels at hospital admission predicting worse outcomes in STEMI patients undergoing PCI: A case series

Acute glycemic variability on admission predicts the prognosis in hospitalized patients with coronary artery disease: a meta-analysis

Contact Info

Product

Resources

About