Glucose fluctuation promotes mitochondrial dysfunctions in the cardiomyocyte cell line HL-1
Patrick Mordel,
Fanny Fontaine,
Quentin Dupas
et al.
Abstract:Aims
Glycemic variability has been suggested as a risk factor for diabetes complications but the precise deleterious mechanisms remain poorly understood. Since mitochondria are the main source of energy in heart and cardiovascular diseases remain the first cause of death in patients with diabetes, the aim of the study was to evaluate the impact of glucose swings on mitochondrial functions in the cardiomyocyte cell line HL-1.
Methods
HL-1 cells were exposed to low (LG, 2.8 mmol/l), normal (NG, 5.5 mmol/l), hi… Show more
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