Impact of glycemic control on serum lipoprotein (a) in Arab children with type 1 diabetes

Alsaeid, Mayra; Qabazard, Maryam; Shaltout, Azza

doi:10.1046/j.1442-200x.2001.01387.x

Cited by 13 publications

(9 citation statements)

References 24 publications

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“…This is a serious situation and needs to be underlined since in T1DM patients, poor metabolic control is usually due to inadequacies in insulin regimens and these patients are at highest risk for complications and cardiovascular disorders even at an early age (23). …”

Section: Discussionmentioning

confidence: 99%

The Role of Osteopontin in the Pathogenesis and Complications of Type 1 Diabetes Mellitus in Children

Talat

Sherief²,

Elsaadany³

et al. 2016

Jcrpe

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Objective:Type 1 diabetes mellitus (T1DM) is the most common chronic metabolic disorder of childhood and adolescence. Osteopontin plays a significant role in the development and progression of several autoimmune diseases. Moreover, osteopontin promotes adipose tissue inflammation, dysfunction, and insulin resistance. To investigate the levels of serum osteopontin in pediatric patients with T1DM and to explore if these levels have a role in the prediction of diabetes complications.Methods:This was a case–control study conducted at the Endocrinology unit of the Children’s Hospital of Zagazig University in Egypt, from October 2014 to December 2015. Sixty patients with T1DM and 60 healthy subjects were enrolled. A detailed medical history was taken from all patients/parents. A full clinical examination including ophthalmoscopy was performed on all patients. Fasting blood glucose, hemoglobin A1c (HbA1c), urine albumin/creatinine ratio, and serum osteopontin levels were also determined in all subjects.Results:Patients with T1DM had significantly higher serum osteopontin levels compared with controls (mean ± standard deviation: 13.7±3.4 μg/L vs. 8.9±2.9 μg/L, p<0.001). Also, serum osteopontin concentrations were higher in patients with microalbuminuria than in patients with normal albumin excretion rate and in the control group. Similarly, those who had retinal disease had higher osteopontin concentrations than those without (16.8±2 vs. 12.4±3 mg/L; p=0.005). Serum osteopontin levels correlated with a diagnosis of T1DM, and in diabetic patients, correlated with higher systolic and diastolic blood pressure, body mass index values and with lower high density lipoprotein values, diagnosis of retinopathy, and microalbuminuria. No correlation was found between osteopontin levels and HbA1c, insulin dose, co-medications, and diabetes duration in T1DM patients. The association between high osteopontin levels and T1DM was independent from all confounders.Conclusion:This study shows that increased osteopontin levels are independently associated with T1DM in pediatric patients and supports the hypothesis that osteopontin may have a role in the prediction of microvascular diabetes complications.

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Section: Discussionmentioning

confidence: 99%

The Role of Osteopontin in the Pathogenesis and Complications of Type 1 Diabetes Mellitus in Children

Talat

Sherief²,

Elsaadany³

et al. 2016

Jcrpe

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“…Lp(a) increases after menopause [25], probably in association with the fall in sexual hormones [26] given that treatment of postmenopausal women with conjugated equine estrogen resulted in a significant reduction in Lp(a) levels [27]. Children with diabetes mellitus type I and poor metabolic control had higher levels of Lp(a) than those with good or fair control [28]. Patients with diabetes mellitus type 2 had higher levels of Lp(a) than non-diabetic subjects, and the levels varied in diabetics with different apo(a) phenotypes [29].…”

Section: Discussionmentioning

confidence: 99%

Atherogenic lipid profile and elevated lipoprotein (a) are associated with lower bone mineral density in early postmenopausal overweight women

Orozco

2004

Eur J Epidemiol

112

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Epidemiological studies have reported that women with osteoporosis present an increased risk of cardiovascular events and that lipid lowering therapy (statins) could be associated with a decreased risk of fracture. We investigated whether women with atherogenic lipid profile have lower lumbar and femoral bone mineral density (BMD) and higher prevalence of osteopenia than those with normal lipid levels. The study included 52 overweight early postmenopausal women, with no history of hormone replacement therapy, or any current or past pathology or treatment that could alter bone or lipid metabolism. Atherogenic lipid profile or hyperlipidemia was defined as hypercholesterolemia (> or = 240 mg/dl) or high low-density lipoprotein cholesterol (high-LDLc > or = 160 mg/dl) or high lipoprotein (a) [high-Lp (a) > or =25 mg/dl], and low-BMD as t-score <-1 SD at lumbar o femoral site. The results show that women with hyperlipidemia had lower mean-adjusted BMD (mean+/-SEM) at lumbar (0.865+/-0.020 vs. 0.958+/-0.028 g/cm2, p = 0.007) and femoral neck (0.712+/-0.015 vs. 0.796+/-0.021, p = 0.004 g/cm2) than those with normal lipid levels. Hypercholesterolemia group had higher prevalence of low-BMD at lumbar spine (82.6% vs. 55.2%, p = 0.04, OR: 3.8; 95% CI: 1.04-14.2) and femoral neck (65.2% vs. 37.9%, p = 0.05, OR: 3.1; 95% CI: 0.98-9.6). The high-LDLc group had also higher prevalence low-BMD at femoral neck (75% vs. 39%, p = 0.01, OR: 4.7; 95% CI: 1.26-17.5), and the high-Lp (a) group at lumbar spine (87% vs. 51.7% p = 0.007, OR: 6.2; 95% CI: 1.5-25.6). Women with hyperlipidemia had higher prevalence of low BMD at lumbar spine (81.8% vs. 42.1%, p = 0.003, OR: 6.2; 95% CI: 1.7-22) and femoral neck (60.6% vs. 31.6%, p = 0.04, OR: 3.3; 95% CI: 1.01-11.0). In conclusion, early postmenopausal women with atherogenic lipid profile, defined as cholesterol > or =240 mg/dl or LDLc > or = 160 mg/dl or Lp(a) > or = 25 mg/dl have lower lumbar and femoral BMD and have an increased risk of osteopenia than those with normal lipid profile, suggesting that hyperlipidemia could be associated with osteoporosis and bone status should be evaluated in women with hyperlipidemia.

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“…Elevated levels of serum Lp(a) is also associated with an increased risk of coronary heart disease in patients with diabetes [13,14]. It is also a predictor of non-proliferative retinopathy in these patients [15][16][17][18][19]. Lp(a) is present in the arterial wall at sites of atherosclerosis in humans and results in both atherogenesis and thrombosis (3).…”

Section: Introductionmentioning

confidence: 99%

Serum Lipoprotein(a) Levels are Greater in Female than Male Patients with Type‐2 Diabetes

Nakhjavani¹,

Morteza²,

Esteghamati³

et al. 2010

Lipids

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Women with diabetes are faced with a higher risk of dyslipidemia and cardiovascular disorders than men with diabetes. We aimed to study the role of gender and menopausal status in serum Lp(a) levels in patients with type 2 diabetes. We quantified serum Lp(a) levels in a group of 477 patients with type 2 diabetes (men, premenopausal and postmenopausal women with diabetes), as well as in 105 controls. We stratified the patients into two groups of low Lp(a) levels (Lp(a) <35 mg/dl) and elevated Lp(a) levels (Lp(a) >35 mg/dl). Patients with diabetes had higher serum Lp(a) levels than the controls. Serum Lp(a) levels was significantly higher in women with diabetes than men with diabetes. Lp(a) levels did not differ between male and females in the control group. Premenopausal and postmenopausal women with diabetes did not differ significantly in serum Lp(a) levels. The odds ratio of having a serum Lp(a) level higher than 35 was 5.85 in premenopausal women with diabetes, 5.08 in postmenopausal women with diabetes, 2.41 in men with diabetes and 1.9 in the women in the control group compared to the men in the control group, after adjustment for age and BMI. This observational study clearly indicated that serum Lp(a) levels were significantly higher in women and men with diabetes. The increase in women was independent of menopause. The level of serum Lp(a) had no correlation with lipid parameters in men or women.

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Impact of glycemic control on serum lipoprotein (a) in Arab children with type 1 diabetes

Cited by 13 publications

References 24 publications

The Role of Osteopontin in the Pathogenesis and Complications of Type 1 Diabetes Mellitus in Children

The Role of Osteopontin in the Pathogenesis and Complications of Type 1 Diabetes Mellitus in Children

Atherogenic lipid profile and elevated lipoprotein (a) are associated with lower bone mineral density in early postmenopausal overweight women

Serum Lipoprotein(a) Levels are Greater in Female than Male Patients with Type‐2 Diabetes

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