Impact of Glucocorticoid Use in Oncology in the Immunotherapy Era

Kalfeist, Laura; Galland, Loïck; Ledys, Fanny; Ghiringhelli, François; Limagne, Emeric; Ladoire, Sylvain

doi:10.3390/cells11050770

Cited by 33 publications

(18 citation statements)

References 171 publications

(197 reference statements)

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“…In this regard, the development of abnormal structural features that inhibit the ability of CTLs to penetrate tumour sites is a hallmark of cancer progression [34]. Evidence is emerging that glucocorticoids act on adhesion of immune cells by inhibiting adhesion molecules (integrins and selectins) [39,40]. The deregulation of adhesion molecules may act as barriers to T cell migration and infiltration.…”

Section: Discussion Conclusion and Research Perspectivesmentioning

confidence: 99%

An individual-based model to explore the impact of psychological stress on immune infiltration into tumour spheroids

Leschiera,

Al-Hity,

Flint

et al. 2024

Phys. Biol.

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In recent in vitro experiments on co-culture between breast tumour spheroids and activated immune cells, it was observed that the introduction of the stress hormone cortisol resulted in a decreased immune cell infiltration into the spheroids. Moreover, the presence of cortisol deregulated the normal levels of the pro- and anti-inflammatory cytokines IFN-γ and IL-10. We present an individual-based model to explore the interaction dynamics between tumour and immune cells under psychological stress conditions. With our model, we explore the processes underlying the emergence of different levels of immune infiltration, with particular focus on the biological mechanisms regulated by IFN-γ and IL-10. The set-up of numerical simulations is defined to mimic the scenarios considered in the experimental study. Similarly to the experimental quantitative analysis, we compute a score that quantifies the level of immune cell infiltration into the tumour. The results of numerical simulations indicate that the motility of immune cells, their capability to infiltrate through tumour cells, their growth rate and the interplay between these cell parameters can affect the level of immune cell infiltration in different ways. Ultimately, numerical simulations of this model support a deeper understanding of the impact of biological stress-induced mechanisms on immune infiltration.

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Section: Discussion Conclusion and Research Perspectivesmentioning

confidence: 99%

An individual-based model to explore the impact of psychological stress on immune infiltration into tumour spheroids

Leschiera,

Al-Hity,

Flint

et al. 2024

Phys. Biol.

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“…Glucocorticoid has anti-inflammatory, anti-edema, anti-allergy and management cancer-related symptoms (compression, pain, edema, etc.) ( 7 ). This result argues that if hormone therapy is given at the early stage, the patient may not experience severe edema later on.…”

Section: Discussionmentioning

confidence: 99%

Trastuzumab treatment of invasive breast ductal carcinoma induces severe edema: a case report

Zhang¹,

Zheng²,

Wang³

et al. 2022

Transl Cancer Res TCR

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Background: Trastuzumab, a monoclonal antibody which binds to the extracellular domain of HER2, is the first biological drug approved for the treatment of human epidermal growth factor receptor 2 (HER2)positive breast cancer. However, trastuzumab exhibits a series of clinical adverse effects, including cardiac toxicity, nerve damage, abnormal liver function, thrombocytopenia, etc.Case Description: We report a case of a 46-year-old female patient with invasive breast ductal carcinoma (classified as Stage 2B) who developed a rare severe edema in neck, face, chest, abdomen and both upper limbs after a single dose trastuzumab treatment. The patient (~60 kg weight) was administered with trastuzumab (420 mg) with an infusion time of 2 hours. The most severe edema symptom was observed in patient's hands, in which the epidermis was markedly transparent and tight. One month after trastuzumab administration, the patient was administered with methylprednisone (80 mg per day) for 5 days. The edema in patient's neck, face and both upper limbs was mildly reduced though the CT image showed no significant reduction of edema.Conclusions: Trastuzumab treatment for breast cancer patients, particularly those who have an allergic constitution, may have an adverse effect to develop severe edema, and treatment with methylprednisone at early stage can reduce such adverse reaction.

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“…Elucidating some of the underlying mechanisms of resistance could help clinicians optimize treatment strategies. Because of the inherently pro-inflammatory therapeutic effect of ICIs, many classes of drugs that might impact the immune system may decrease their efficacy, most notably corticosteroids [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Comedications with Immune Checkpoint Inhibitors: Involvement of the Microbiota, Impact on Efficacy and Practical Implications

Colard-Thomas

Thomas

Viala

2023

Cancers

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Immune checkpoint inhibitors (ICIs) have been a major breakthrough in solid oncology over the past decade. The immune system and the gut microbiota are involved in their complex mechanisms of action. However, drug interactions have been suspected of disrupting the fine equilibrium necessary for optimal ICI efficacy. Thus, clinicians are facing a great deal of sometimes contradictory information on comedications with ICIs and must at times oppose conflicting objectives between oncological response and comorbidities or complications. We compiled in this review published data on the role of the microbiota in ICI efficacy and the impact of comedications. We found mostly concordant results on detrimental action of concurrent corticosteroids, antibiotics, and proton pump inhibitors. The timeframe seems to be an important variable each time to preserve an initial immune priming at ICIs initiation. Other molecules have been associated with improved or impaired ICIs outcomes in pre-clinical models with discordant conclusions in retrospective clinical studies. We gathered the results of the main studies concerning metformin, aspirin, and non-steroidal anti-inflammatory drugs, beta blockers, renin-angiotensin-aldosterone system inhibitors, opioids, and statins. In conclusion, one should always assess the necessity of concomitant treatment according to evidence-based recommendations and discuss the possibility of postponing ICI initiation or switching strategies to preserve the critical window.

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Impact of Glucocorticoid Use in Oncology in the Immunotherapy Era

Cited by 33 publications

References 171 publications

An individual-based model to explore the impact of psychological stress on immune infiltration into tumour spheroids

An individual-based model to explore the impact of psychological stress on immune infiltration into tumour spheroids

Trastuzumab treatment of invasive breast ductal carcinoma induces severe edema: a case report

Comedications with Immune Checkpoint Inhibitors: Involvement of the Microbiota, Impact on Efficacy and Practical Implications

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