Impact of geriatric risk factors on pegylated liposomal doxorubicin tolerance and efficacy in elderly metastatic breast cancer patients: Final results of the DOGMES multicentre GINECO trial

Falandry, Claire; Brain, Étienne; Bonnefoy, Marc; Mefti, F.; Jovenin, Nicolas; Rigal, Olivier; Guillem, Olivier; Kouri, Claude El; Uwer, Lionel; Abadie‐Lacourtoisie, Sophie; Crétin, J; Jacquin, J-P; Paraïso, D.; Freyer, Gilles

doi:10.1016/j.ejca.2013.04.027

Cited by 30 publications

(32 citation statements)

References 37 publications

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“…It has been previously shown that this approach can offer considerable benefits in various settings and medical conditions and, in oncology, it can provide clinical information that is not revealed by performance status [3][4][5]. Recent oncological studies have shown that some of the geriatric parameters (mainly included in the complete CGA) are predictive of chemotherapy toxicity, and specific scores have been identified in order to help physicians in everyday clinical practice [6][7][8].…”

Section: Introductionmentioning

confidence: 98%

Estimating the risk of chemotherapy toxicity in older patients with cancer: The role of the Vulnerable Elders Survey-13 (VES-13)

Luciani

Biganzoli

Colloca

et al. 2015

Journal of Geriatric Oncology

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Section: Introductionmentioning

confidence: 98%

Estimating the risk of chemotherapy toxicity in older patients with cancer: The role of the Vulnerable Elders Survey-13 (VES-13)

Luciani

Biganzoli

Colloca

et al. 2015

Journal of Geriatric Oncology

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“…Similarly, both the G8 and the VES-13 have also been used to predict treatment-related toxicity [21]. Additionally, single domains from the GA have been identified to be of prognostic value for toxicities in elderly patients undergoing chemotherapy [12,22,23]. …”

Section: Introductionmentioning

confidence: 99%

A Questionnaire Study to Assess the Value of the Vulnerable Elders Survey, G8, and Predictors of Toxicity as Screening Tools for Frailty and Toxicity in Geriatric Cancer Patients

et al. 2016

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Background: The aim of this study was to identify an appropriate screening instrument for the identification of frail elderly patients in a tertiary cancer center. In order to improve cancer care for older patients, the use of a geriatric assessment (GA) has been proposed to identify frail patients or those who are at a higher risk for chemotherapy-related toxicities. In busy clinical routine, an appropriate screening instrument could be used to spare time- and resource-consuming application of GA. Patients and Methods: We administered the Vulnerable Elders Survey (VES-13), G8 questionnaire, and Predictors of Toxicity (POT) as well as a GA at the first visit of 84 consecutive patients at a single Comprehensive Cancer Center. Analysis for patients' characteristics as well as sensitivity, specificity, and positive and negative predictive value (npv) was conducted. Results: The median age of the patients was 73 years (range 63-93 years), 61.9% were male, most (63%) suffered from gastrointestinal tumors, 39.3% had a multiple cancer diagnosis, and 53.6% had metastasis. 30 (35.7%) individuals were classified as ‘frail' by the GA. Sensitivity of G8 was 38.3%, and the npv was 63.8%. Sensitivity for VES-13 was 57.1%, and npv was 76.3%. Sensitivity of POT was 72.7%, and the npv was 80.6%. Conclusion: For the first time, the VES-13, G8, and POT are compared in a sample of older German patients. The POT seems to be a sufficient screening tool to identify frail patients in a tertiary referral cancer center and helps to save time and resources compared with a complete GA.

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“…Although localized cancers may be successfully treated resorting to radiation therapy [18] and/or surgery [32], chemotherapy is the standard treatment for advanced or metastasized cancer. Nonetheless, commonly used chemotherapeutic agents, such as doxorubicin and cisplatin, inadvertently induce damage in healthy cells and tissues, resulting in numerous deleterious side-effects [16]. Additionally, some cancer cells may be quiescent, or show slow proliferation rate and, thus, are refractory to the cytotoxic effect of chemotherapeutic drugs acting at the DNA synthesis level [31].…”

Section: Introductionmentioning

confidence: 99%

Anti-tumoral activity of human salivary peptides

et al. 2015

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Chemotherapy continues to be the standard treatment for advanced or metastasized cancer. However, commonly used chemotherapeutic agents may induce damage in healthy cells and tissues. Thus, in recent years, there has been an increased focus on the development of new, efficient anticancer drugs exhibiting low toxicity and that are not affected by mechanisms of chemoresistance. In the present work, we tested synthetic and naturally obtained human salivary peptides against breast, prostate, colon, osteosarcoma and bladder cancer cell lines (T47-D, PC-3, HT-29, MG63, T-24, respectively). Results have showed that there is a reduced cell population increase that is peptide-, cell- and possibly pathway-specific, with the most potent effect observed in observed in T-47D breast cancer cells. Protein expression and microscopy results further indicate that, in this cell line, the peptide with the sequence GPPPQGGRPQG (GG peptide) interferes with the ability of cell adhesion proteins to stabilize adherens junctions, such as E-cadherin, leading to apoptosis. These promising results encourage future works aimed at disclosing the vast potential of salivary peptides as new therapeutic agents.

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Impact of geriatric risk factors on pegylated liposomal doxorubicin tolerance and efficacy in elderly metastatic breast cancer patients: Final results of the DOGMES multicentre GINECO trial

Cited by 30 publications

References 37 publications

Estimating the risk of chemotherapy toxicity in older patients with cancer: The role of the Vulnerable Elders Survey-13 (VES-13)

Estimating the risk of chemotherapy toxicity in older patients with cancer: The role of the Vulnerable Elders Survey-13 (VES-13)

A Questionnaire Study to Assess the Value of the Vulnerable Elders Survey, G8, and Predictors of Toxicity as Screening Tools for Frailty and Toxicity in Geriatric Cancer Patients

Anti-tumoral activity of human salivary peptides

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