Impact of Genetic Variants of Long Noncoding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 on Uterine Cervical Cancer

Abstract

Genetic variants of long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (lncRNA MALAT1) have been reported to be associated with several cancers. Until now, no study reveals the associations between lncRNA MALAT1 polymorphisms and cervical cancer (CC). The objectives of this study were to explore the correlations among MALAT1 polymorphisms and occurrence and clinicopathological parameters of CC, as well as patient 5 years survival in Taiwanese women. The study recruited 116 patients with cervical invasive cancer and 89 patients with cervical precancerous lesions, as well as 268 non-cancer control women. LncRNA MALAT1 polymorphisms rs3200401, rs619586 and rs1194338 were selected and their genotypic frequencies were defined by real-time polymerase chain reaction. Our results revealed that there are no relationships between lncRNA MALAT1 genetic variants and occurrence of CC. The independent factor among lncRNA MALAT1 genetic variants and clinicopathological parameters were positive pelvic lymph node metastasis (p=0.001, HR: 10.94, 95% CI: 2.65-45.23). In conclusions, lncRNA MALAT1 genetic variants are not related to occurrence and clinicopathological characteristics of CC and patient 5 years survival in Taiwanese women. Pelvic lymph node metastasis could independently predict the patient 5 years survival among various MALAT1 polymorphisms and clinicopathological factors in CC.

Association between genetic variants (rs920778, rs4759314, and rs217727) in LncRNAs and cervical cancer susceptibility in Chinese population: A systematic review and meta-analysis

“…Finally, we pooled the data of 59 SNPs from 11 different LncRNAs in 21 case-control studies (19 English and 2 Chinese publications) (Guo et al, 2015;Guo et al, 2016;Han et al, 2016;Jin et al, 2016;Qiu et al, 2016;Wu et al, 2016;He and Wei, 2017;Jin et al, 2017;Zhu et al, 2017;Wang and Luo, 2018;Weng et al, 2018;Huang et al, 2019;Jia et al, 2019;Gao et al, 2020;Minn et al, 2020;Wang et al, 2020;Weng et al, 2020;Sun et al, 2022;Yao et al, 2022;Yi et al, 2022). Details of these studies and the distribution of SNPs genotype are shown in Supplementary Table S1.…”

“…Then, 12 articles were excluded, including 10 articles for which genotype data were not available, 1 article for which the abstract was available, and 1 article for which the full text was not available ( Figure 1 ). Finally, we pooled the data of 59 SNPs from 11 different LncRNAs in 21 case-control studies (19 English and 2 Chinese publications) ( Guo et al, 2015 ; Guo et al, 2016 ; Han et al, 2016 ; Jin et al, 2016 ; Qiu et al, 2016 ; Wu et al, 2016 ; He and Wei, 2017 ; Jin et al, 2017 ; Zhu et al, 2017 ; Wang et al, 2018 ; Wang and Luo, 2018 ; Weng et al, 2018 ; Huang et al, 2019 ; Jia et al, 2019 ; Gao et al, 2020 ; Minn et al, 2020 ; Wang et al, 2020 ; Weng et al, 2020 ; Sun et al, 2022 ; Yao et al, 2022 ; Yi et al, 2022 ). Details of these studies and the distribution of SNPs genotype are shown in Supplementary Table S1 .…”

“…H19 rs217727 showed no correlation with cervical cancer susceptibility in the five gene models. Previous meta-analyses have discussed SNPs and the risk of cervical cancer in different LncRNAs ( Sun et al, 2022 ; Yao et al, 2022 ). This systematic review and meta-analysis was the first to summarize and evaluate all relevant literature in human studies focusing on LncRNA polymorphisms in cervical cancer.…”

Mechanistic studies of MALAT1 in respiratory diseases

“…In patients with ovarian cancer, high levels of MALAT1 expression in localized lesions or in serum exosomes may indicate a poor prognosis ( Lin et al, 2018 ; Qiu et al, 2018 ). However, a study conducted in Taiwan showed that lncRNA MALAT1 gene variants are not associated with the incidence, clinicopathological characteristics, or the 5-year survival rates of women with cervical cancer ( Sun YH. et al, 2021 ).…”

Evaluation of the clinical significance of long non-coding RNA MALAT1 genetic variants in human lung adenocarcinoma

“…Recent studies have shown that genetic variations, such as those prevalent universally present in lncRNA genes, may directly or indirectly affect lncRNA expression levels in multiple ways to regulate tumor development [ 27 , 28 ]. Previous studies have reported that the MALAT1 polymorphisms were associated with cancer development, carcinogenesis and prognosis in various cancers such as hepatocellular carcinoma [ 29 ], cervical cancer [ 30 ], oral squamous cell carcinoma [ 31 ], and prostate cancer [ 32 ]. However, only a small number of researches have looked into the connection between MALAT1 SNPs and lung cancer [ 33 , 34 ].…”