Impact of exercise training on muscle mitochondria modifications in older adults: a systematic review of randomized controlled trials

Lippi, Lorenzo; Sire, Alessandro de; Mezian, Kamál; Curci, Claudio; Perrero, Luca; Turco, Alessio; Andaloro, Silvia; Ammendolia, Antonio; Fusco, Nicola; Invernizzi, Marco

doi:10.1007/s40520-021-02073-w

Cited by 36 publications

(34 citation statements)

References 56 publications

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“…Beyond smoke cessation, patients should be instructed to reduce their sedentary behavior, especially elderly COPD patients, in light of the molecular anti-aging role of physical activity and the beneficial effects on BMD [ 131 , 132 ]. National and international recommendations recommend that physical exercise programs should be included in the comprehensive lifestyle approach to COPD to improve symptoms of these patients [ 131 ].…”

Section: Lifestyle Approach and Smoke Cessationmentioning

confidence: 99%

Pharmacological, Nutritional, and Rehabilitative Interventions to Improve the Complex Management of Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease: A Narrative Review

Sire

Lippi

Aprile

et al. 2022

JPM

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Osteoporosis is a highly prevalent condition affecting a growing number of patients affected by chronic obstructive pulmonary disease (COPD), with crucial implications for risk of fragility fractures, hospitalization, and mortality. Several risk factors have been identified to have a role in osteoporosis development in COPD patients, including corticosteroid therapy, systemic inflammation, smoke, physical activity levels, malnutrition, and sarcopenia. In this scenario, a personalized multitarget intervention focusing on the pathological mechanisms underpinning osteoporosis is mandatory to improve bone health in these frail patients. Specifically, physical exercise, nutritional approach, dietary supplements, and smoke cessation are the cornerstone of the lifestyle approach to osteoporosis in COPD patients, improving not only bone health but also physical performance and balance. On the other hand, pharmacological treatment should be considered for both the prevention and treatment of osteoporosis in patients at higher risk of fragility fractures. Despite these considerations, several barriers still affect the integration of a personalized approach to managing osteoporosis in COPD patients. However, digital innovation solutions and telemedicine might have a role in optimizing sustainable networking between hospital assistance and community settings to improve bone health and reduce sanitary costs of the long-term management of COPD patients with osteoporosis.

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Section: Lifestyle Approach and Smoke Cessationmentioning

confidence: 99%

Pharmacological, Nutritional, and Rehabilitative Interventions to Improve the Complex Management of Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease: A Narrative Review

Sire

Lippi

Aprile

et al. 2022

JPM

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“…In older adults, sarcopenia might reflect the impaired muscle quality related to several factors, including altered oxidative capacity, impaired muscle mitochondrial function, and abnormal systemic inflammation. All these pathophysiological pathways are frequent in COPD patients [ 22 , 23 ], and recent research has underlined that muscle–skeletal tissues in these patients might be affected by metabolic alterations related to deconditioning and the hypoxic state. These modifications promote the shifting towards a glycolytic muscle fibre distribution, with a reduced cross-sectional area and capillary density [ 24 ].…”

Section: Copd and Osteosarcopenia: A Negative Bond For Physical Frailtymentioning

confidence: 99%

“…Interestingly, a recent study focused on the role of probiotics on vitamin D and intestinal calcium absorption, highlighting their role in the prevention of hyperparathyroidism and BMD loss [ 92 ]. Lastly, recent research has emphasized the effects of several nutraceutical and nutritional interventions on inflammation and mitochondrial activity, suggesting potential implications of specific supplementation in targeting biomolecular pathways involved in skeletal muscle wasting [ 22 ].…”

Section: Malnutrition Skeletal Muscle Impairment and Risk Of Fallingmentioning

confidence: 99%

Osteosarcopenia in Patients with Chronic Obstructive Pulmonary Diseases: Which Pathophysiologic Implications for Rehabilitation?

Lippi

Folli

Curci

et al. 2022

IJERPH

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Chronic obstructive pulmonary disease (COPD) is a burdensome condition affecting a growing number of people worldwide, frequently related to major comorbidities and functional impairment. In these patients, several factors might have a role in promoting both bone and muscle loss, including systemic inflammation, corticosteroid therapies, sedentary behaviours, deconditioning, malnutrition, smoking habits, and alcohol consumption. On the other hand, bone and muscle tissues share several linkages from functional, embryological, and biochemical points of view. Osteosarcopenia has been recently defined by the coexistence of osteoporosis and sarcopenia, but the precise mechanisms underpinning osteosarcopenia in patients with COPD are still unknown. In this scenario, a deeper understanding of the molecular basis of osteosarcopenia might guide clinicians in a personalized approach integrating skeletal muscle health with the pulmonary rehabilitation framework in COPD. Taken together, our results summarized the currently available evidence about the multilevel interactions between osteosarcopenia and COPD to pave the way for a comprehensive approach targeting the most common risk factors of these pathological conditions. Further studies are needed to clarify the role of modern clinical strategies and telemedicine solutions to optimize healthcare delivery in patients with COPD, including osteopenia, osteoporosis, and sarcopenia screening in these subjects.

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“…Emerging studies are highlighting the role of reactive oxygen species production and oxidative stress in muscle damage, regeneration, and DOMS [ 10 , 11 , 12 , 13 , 14 ]. Earlier, the source of reactive oxygen species production and oxidative stress was mainly revealed in muscles [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

CD3+/CD56+ NKT-like Cells Show Imbalanced Control Immediately after Exercise in Delayed-Onset Muscle Soreness

Sonkodi

Pállinger

Radovits

et al. 2022

IJMS

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The purpose of the study was to carry out an immunophenotypical characterization with a special focus on natural killer cells of junior swimmers from the Hungarian National Swim Team before and after an intensive acute exercise. Nineteen swimmers, ten females and nine males, completed the exercise protocol. Sixteen swimmers experienced delayed-onset muscle soreness. Most of our findings substantiated earlier results, such as the increase in the percentage of the CD3−/CD56+ natural killer cells and the CD3−/CD56dim+ NK cells, and the decrease in the percentage of CD3+ T cells among lymphocytes after the exercise protocol. The drop of natural killer cell activity back to the pre-exercise level was in line with earlier findings. Interestingly, the percentage of CD3+/CD56+ NKT-like cells did not change significantly in those three swimmers who did not report delayed-onset muscle soreness. On the contrary, the percentage of CD3+/CD56+ NKT-like cells among lymphocytes increased in fourteen and decreased in two swimmers reporting delayed-onset muscle soreness. This study for the first time demonstrated a link between the delayed-onset muscle soreness and the imbalanced control of CD3+/CD56+ NKT-like cells among lymphocytes. However, validation of this association in a larger sample size study will be necessary.

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Impact of exercise training on muscle mitochondria modifications in older adults: a systematic review of randomized controlled trials

Cited by 36 publications

References 56 publications

Pharmacological, Nutritional, and Rehabilitative Interventions to Improve the Complex Management of Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease: A Narrative Review

Pharmacological, Nutritional, and Rehabilitative Interventions to Improve the Complex Management of Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease: A Narrative Review

Osteosarcopenia in Patients with Chronic Obstructive Pulmonary Diseases: Which Pathophysiologic Implications for Rehabilitation?

CD3+/CD56+ NKT-like Cells Show Imbalanced Control Immediately after Exercise in Delayed-Onset Muscle Soreness

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