Impact of Epidemic Rates of Diabetes on the Chinese Blood Glucose Testing Market

Hu, Jamie; Zhang, Xian-En

doi:10.1177/193229681100500540

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…5,6 The simplicity and robustness of the design enables manufacturing of disposable glucose sensing electrodes for less than US$0.1. 7 Yet, the technological and commercial success of glucose sensors has not been paralleled by other electrochemical biosensors despite both the clinical demand and the commercial potential of point-of-care diagnostics. This can at least in parts be explained by the unique features of glucose sensing where the analyte is present at high concentrations (4-20 mM) and also provides the source of energy for a selective, physically stable electrochemical receptor with high turnover rate.…”

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confidence: 99%

Engineering PQQ-glucose dehydrogenase into an allosteric electrochemical Ca²⁺ sensor

et al. 2016

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Electrochemical biosensors convert biological events to an electrical current. To date most electrochemical biosensors exploit activities of naturally occurring enzymes. Here we demonstrated that insertion of a calmodulin domain into the redox enzyme PQQ-glucose dehydrogenase resulted in a selective Ca(2+) biosensor that could be used to rapidly measure Ca(2+) concentrations in human biological fluids. We were able to convert a point-of-care glucometer into Ca(2+) monitor by refurbishing it with the developed biosensor. We propose that similar engineering strategies may be used to create highly specific electrochemical biosensors to other analytes. Compatibility with cheap and ubiquitous amperometric detectors is expected to accelerate progression of these biosensors into clinical applications.

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Engineering PQQ-glucose dehydrogenase into an allosteric electrochemical Ca²⁺ sensor

et al. 2016

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“…Diabetes mellitus (DM) is a major degenerative ailment in the world today, affecting at least 100 million people in China (Hu, Zhang, 2011) and resulting in severe metabolic imbalances and pathological changes in many tissues. Diabetic peripheral neuropathy (DPN) is one of the most common secondary complications of diabetes, which affects approximately 70-90% of the world's population suffering from diabetes (Cow, 1997).…”

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confidence: 99%

Protective effect of mulberry flavonoids on sciatic nerve in alloxan-induced diabetic rats

Dong-lian

Deng

et al. 2014

Braz. J. Pharm. Sci.

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Mulberry leaves (Morus alba L.) are a traditional Chinese medicine for blood serum glucose reduction. This study evaluated the protective effects of mulberry flavonoids on sciatic nerve in alloxan-induced diabetic rats. In this study, 80 Sprague-Dawley rats were divided into five groups: A (control), B (diabetic treated with saline), C-D (diabetic treated with 0.3, 0.1 g/kg mulberry flavonoids once a day for 8 weeks) and E (diabetic treated with 0.3 mg/kg methycobal). The diabetic condition was induced by intraperitoneal injection of 200 mg/kg alloxan dissolved in saline. At the end of the experimental period, blood, and tissue samples were obtained for biochemical and histopathological investigation. Treatment with 0.3 g/kg mulberry flavonoids significantly inhibited the elevated serum glucose (P< 0.01). The increased myelin sheath area (P< 0.01), myelinated fiber cross-sectional area and extramedullary fiber number (P< 0.05) were also reduced in alloxan-induced rats treated with 0.3 g/kg mulberry flavonoids. 0.3 g/kg mulberry flavonoids also markedly decreased onion-bulb type myelin destruction and degenerative changes of mitochondria and Schwann cells. These findings demonstrate that mulberry flavonoids may improve the recovery of a severe peripheral nerve injury in alloxan-induced diabetic rats and is likely to be useful as a potential treatment on peripheral neuropathy (PN) in diabetic rats. Uniterms:Morus alba L./pharmacognosy. Mulberry flavonoids/protective effects/experimental study. Diabetic neuropathy/experimental study. Medicinal plants. Diabetics/treatment/experimental study.Folhas de amoreira (Morus alba L.) é um medicamento tradicional chinês para a redução da glicose no soro sanguíneo. Avaliaram-se, neste trabalho, os efeitos protetores dos flavonóides de amora no nervo ciático em ratos diabéticos aloxano-induzidos. Dividiram-se 80 ratos Sprague-Dawley em cinco grupos: A (controle), B (diabétidos tratados com solução salina), C-D (diabéticos tratados com 0,3, 0,1 g/kg) e E (diabéticos tratados com 0,3 mg de metilcobal).A diabetes foi induzida por injeção intraperitoneal de 200 mg/kg de aloxana dissolvida em solução salina. No final do período experimental, obtiveramse amostras de sangue e de tecido para investigação bioquímica e histopatológica. O tratamento com 0,3 g/kg de flavonóides da amoreira inibiu, significativamente, a elevação de glicose no soro (p <0,01). O aumento da área da bainha de mielina (p <0,01), da área de fibra da seção transversal e do número de fibras mielinizadas extramedulares (p <0,05) foi também reduzido em ratos aloxânicos, tratados com 0,3 g/kg flavonóides de amora. Flavonóides da amoreira na dose de 0,3 g/kg também diminuiram, acentuadamente, a destruição da mielina do tipo bulbo de cebola e as alterações degenerativas das células mitocôndrias e das células de Schwann. Estes resultados demonstram que os flavonóides da amoreira podem melhorar a recuperação de uma lesão nervosa periférica grave em ratos com diabetes, induzida por aloxana, e parece ser útil como tratament...

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Impact of Epidemic Rates of Diabetes on the Chinese Blood Glucose Testing Market

Cited by 2 publications

References 7 publications

Engineering PQQ-glucose dehydrogenase into an allosteric electrochemical Ca²⁺ sensor

Engineering PQQ-glucose dehydrogenase into an allosteric electrochemical Ca²⁺ sensor

Protective effect of mulberry flavonoids on sciatic nerve in alloxan-induced diabetic rats

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Impact of Epidemic Rates of Diabetes on the Chinese Blood Glucose Testing Market

Cited by 2 publications

References 7 publications

Engineering PQQ-glucose dehydrogenase into an allosteric electrochemical Ca2+ sensor

Engineering PQQ-glucose dehydrogenase into an allosteric electrochemical Ca2+ sensor

Protective effect of mulberry flavonoids on sciatic nerve in alloxan-induced diabetic rats

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Engineering PQQ-glucose dehydrogenase into an allosteric electrochemical Ca²⁺ sensor

Engineering PQQ-glucose dehydrogenase into an allosteric electrochemical Ca²⁺ sensor