Protective effect of mulberry flavonoids on sciatic nerve in alloxan-induced diabetic rats

Ma, Song-Tao; Dong-lian, Liu; Deng, Jingjing; Peng, Yanjuan

doi:10.1590/s1984-82502014000400012

Cited by 9 publications

(6 citation statements)

References 16 publications

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“…Normal body weight that was observed in the treated group suggests that MLE is safe for consumption at the experimental dose. This finding was in agreement with studies of Song-Tao et al (21), Davoud et al (22) and Singab et al (19) who observed a body weight gain upon betterment of the diabetes status.…”

Section: Discussionsupporting

confidence: 93%

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et al. 2016

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The current study was designed to investigate the changes of the resistin, aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels of diabetic rats after treatment with Morus alba leaves flavonoid extract (MLE) and Morus alba leaves powder (MLP). Thirty male wistar rats in five groups including control and diabetic groups were included. Diabetic groups consisted of diabetic control, sham and treated group with MLE and MLP. Type 2 diabetes was induced in rats by administration of streptozotocin (STZ) and nicotinamide. The serum concentrations of resistin and insulin in the study groups were identified by ELISA. ALT and AST activities were assayed by spectrophotometer. For the first time, it was shown that the uptake of MLE and MLP by diabetic rats could significantly decrease the serum fasting blood sugar (FBS), resistin levels and enzymes activity of ALT and AST and increases the concentration of serum insulin significantly (P<0.05). in comparison with the sham group and diabetic control. The results showed that there was no significant difference between the anti-diabetic and inflammatory properties of MLE and MLP. In this study, the possible protective effect of MLE and MLP administration was evaluated against destructive effect of STZ on liver and pancreas function in diabetic rats. The results showed that these effects may play an important role in the regulating of adipokines secretion such as resistin and insulin secretion which are involved in the control of diabetes and obesity. MLE and MLP treatment could be useful agents in combination with other therapies in diabetes improvement.

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Section: Discussionsupporting

confidence: 93%

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et al. 2016

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“…In particular, all studies did not report a method to randomly divide animals into groups and pick them for assessing outcomes. Only six studies performed the blinding of caregivers and researchers [ 22 - 27 ]. Two studies stating the observators were blind in assessing the outcomes were considered low bias for blinding of detection bias [ 22 , 26 ].…”

Section: Resultsmentioning

confidence: 99%

“…Accordingly, the oral administration of these compounds led to an increase in the myelin sheath area and the myelinated fiber cross-sectional area. The study demonstrated that the extramedullary fiber number, the onion-bulb type myelin destruction, and the degeneration of mitochondria and Schwann cells reduced remarkably [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

Effects of Mulberry on The Central Nervous System: A Literature Review

Tam

Nam

Elhady

et al. 2020

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Background: Mulberry, including several species belonging to genus Morus, has been widely used as a traditional medicine for a long time. Extracts and active components of mulberry have many positive neurological and biological effects and can become potential candidates in the search for new drugs for neurological disorders. Objectives: We aimed to systematically review the medical literature for evidence of mulberry effects on the central nervous system. Methods: We conducted a systematic search in nine databases. We included all in vivo studies investigating the effect of mulberry on the central nervous system with no restrictions. Results: We finally included 47 articles for quality synthesis. Our findings showed that mulberry and its components possessed an antioxidant effect, showed a reduction in the cerebral infarct volume after stroke. They also improved the cognitive function, learning process, and reduced memory impairment in many animal models. M. alba and its extracts ameliorated Parkinson's disease-like behaviors, limited the complications of diabetes mellitus on the central nervous system, possessed anti-convulsant, anti-depressive, and anxiolytic effects. Conclusion: Mulberry species proved beneficial to many neurological functions in animal models. The active ingredients of each species, especially M. alba, should be deeper studied for screening potentially candidates for future treatments

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“…As indicated by Song-Tao et al, mulberry flavonoids and methycobal alleviated the suppression of the average optical density of myelin sheath and myelinated extramedullary fiber cross-sectional area in diabetic rats. Furthermore, animals pretreated with 0.3 g/kg mulberry flavonoids showed ultrastructural features of myelin, remarkable axonal improvement and considerable decrement of myelin breakdown [119]. Astragaloside IV, as another polyphenol, suppressed a decrease in myelinated fiber area and density and segmental demyelination in diabetic rats by decreasing the hemoglobin A1c (HbA1C) and AR levels in erythrocytes, increasing the plasma insulin levels, and GPx activity in nerves.…”

Section: Improvement Of Nerve Growth Factorsmentioning

confidence: 99%

Polyphenols for diabetes associated neuropathy: Pharmacological targets and clinical perspective

et al. 2019

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Objectives Diabetic neuropathy (DNP) is a widespread and debilitating complication with complex pathophysiology that is caused by neuronal dysfunction in diabetic patients. Conventional therapeutics for DNP are quite challenging due to their serious adverse effects. Hence, there is a need to investigate novel effective and safe options. The novelty of the present study was to provide available therapeutic approaches, emerging molecular mechanisms, signaling pathways and future directions of DNP as well as polyphenols' effect, which accordingly, give new insights for paving the way for novel treatments in DNP. Evidence acquisition A comprehensive review was done in electronic databases including Medline, PubMed, Web of Science, Scopus, national database (Irandoc and SID), and related articles regarding metabolic pathways on the pathogenesis of DNP as well as the polyphenols' effect. The keywords "diabetic neuropathy" and "diabetes mellitus" in the title/abstract and "polyphenol" in the whole text were used. Data were collected from inception until May 2019. Results DNP complications is mostly related to a poor glycemic control and metabolic imbalances mainly inflammation and oxidative stress. Several signaling and molecular pathways play key roles in the pathogenesis and progression of DNP. Among natural entities, polyphenols are suggested as multi-target alternatives affecting most of these pathogenesis mechanisms in DNP. Conclusion The findings revealed novel pathogenicity signaling pathways of DNP and affirmed the auspicious role of polyphenols to tackle these destructive pathways in order to prevent, manage, and treat various diseases.

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Protective effect of mulberry flavonoids on sciatic nerve in alloxan-induced diabetic rats

Cited by 9 publications

References 16 publications

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Effects of Mulberry on The Central Nervous System: A Literature Review

Polyphenols for diabetes associated neuropathy: Pharmacological targets and clinical perspective

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